Autophagy And Metabolic Syndrome From Molecular Mechanisms To Clinical Consequences


Autophagy And Metabolic Syndrome From Molecular Mechanisms To Clinical Consequences
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Autophagy And Metabolic Syndrome From Molecular Mechanisms To Clinical Consequences


Autophagy And Metabolic Syndrome From Molecular Mechanisms To Clinical Consequences
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Author : Esther Bennett
language : en
Publisher: Hayle Medical
Release Date : 2023-09-26

Autophagy And Metabolic Syndrome From Molecular Mechanisms To Clinical Consequences written by Esther Bennett and has been published by Hayle Medical this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.


Autophagy is a process in which cells capture their own cytoplasm and organelles and consume them in lysosomes. This mechanism preserves the health of cells and tissues through the replacement of damaged and outdated cellular components with new ones. The breakdown products serve as inputs to cellular metabolism. Autophagy prevents degenerative diseases as it is a powerful promoter of metabolic homeostasis at both the cellular and whole animal level. It reduces ubiquitinated protein accumulation in the brain, and disposes-off the aggregation-prone proteins and damaged organelles that cause Huntington's disease and Parkinson's disease. The metabolic syndrome refers to a group of medical conditions which increase the likelihood of heart disease, diabetes and stroke. It encompasses high blood sugar, hypertension, high cholesterol levels and excess fat around the waist. The process of autophagy has an effect on the development of metabolic syndrome since the metabolic syndrome is caused due to the accumulation of damaged cellular constituents. This book includes some of the vital pieces of works being conducted across the world, on various topics related to autophagy and metabolic syndrome. It is appropriate for students seeking detailed information in this area of medicine as well as for experts.



Interplay Between Autophagy And Metabolic Syndrome Causes Consequences And Therapeutic Challenges


Interplay Between Autophagy And Metabolic Syndrome Causes Consequences And Therapeutic Challenges
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Author : Joilson O. Martins
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-01

Interplay Between Autophagy And Metabolic Syndrome Causes Consequences And Therapeutic Challenges written by Joilson O. Martins and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-01 with Science categories.




Autophagy And Cardiometabolic Diseases


Autophagy And Cardiometabolic Diseases
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Author : Jun Ren
language : en
Publisher: Academic Press
Release Date : 2018-04-12

Autophagy And Cardiometabolic Diseases written by Jun Ren and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-12 with Medical categories.


Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations



Metabolic Cardiomyopathy


Metabolic Cardiomyopathy
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Author : H. Böhles
language : en
Publisher: CRC Press
Release Date : 2004

Metabolic Cardiomyopathy written by H. Böhles and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cardiomyopathy categories.


During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.



Cell Death


Cell Death
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Author : Tobias Ntuli
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-12-16

Cell Death written by Tobias Ntuli and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-16 with Science categories.


This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.



Autophagy In Health And Disease


Autophagy In Health And Disease
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Author : Roberta A. Gottlieb
language : en
Publisher: Academic Press
Release Date : 2012-12-31

Autophagy In Health And Disease written by Roberta A. Gottlieb and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.


Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables



Characteristic Clinical Immune Phenotypes And Molecular Mechanisms Associated With Inflammatory Diseases


Characteristic Clinical Immune Phenotypes And Molecular Mechanisms Associated With Inflammatory Diseases
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Author : Chengjin Gao
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-19

Characteristic Clinical Immune Phenotypes And Molecular Mechanisms Associated With Inflammatory Diseases written by Chengjin Gao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-19 with Medical categories.


The systemic inflammatory response is evident in inflammatory diseases, and the immune system secretes many cytokines involved, resulting in a robust immune response. For example, the pathogenesis of sepsis includes abnormal immune cell activation in the early stages as well as sepsis-related immunosuppression. During the immunosuppressive phase, CD4+ T cells, CD8+ T cells, Th17 cells, and γδ T cells are reduced while regulatory T cells increase. At the same time, T lymphocytes and neutrophils, as immune effector cells, interact with each other and play a key role in regulating the immune response to immune-inflammatory diseases. The increased release of neutrophil extracellular trap networks (NETs) by neutrophils leads to a significant upregulation of NETs-DNA-MPO, which further aggravates the septic inflammatory response and organ functional impairment. Therefore, it is important to deeply investigate the characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases, and targeting therapies against them may provide new ideas for the precise treatment of diseases.



The Retardation Of Aging And Disease By Dietary Restriction


The Retardation Of Aging And Disease By Dietary Restriction
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Author : Richard Weindruch
language : en
Publisher: Charles C Thomas Pub Limited
Release Date : 1988-01-01

The Retardation Of Aging And Disease By Dietary Restriction written by Richard Weindruch and has been published by Charles C Thomas Pub Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-01-01 with Health & Fitness categories.




Molecular Mechanisms Of Atherosclerosis


Molecular Mechanisms Of Atherosclerosis
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Author : Joseph Loscalzo
language : en
Publisher: CRC Press
Release Date : 2004-12-22

Molecular Mechanisms Of Atherosclerosis written by Joseph Loscalzo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-22 with Medical categories.


Atherosclerosis is the most common cardiovascular disorder in western societies and is rapidly becoming similarly prevalent in the underdeveloped world. Written by notable authorities and providing text rich in illustrative figures, Molecular Mechanisms in Atherosclerosis addresses the fundamental mechanisms underlying atherothrombosis and delineat



Pharmacological Properties Of Plant Derived Natural Products And Implications For Human Health


Pharmacological Properties Of Plant Derived Natural Products And Implications For Human Health
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Author : George E. Barreto
language : en
Publisher: Springer Nature
Release Date : 2021-04-16

Pharmacological Properties Of Plant Derived Natural Products And Implications For Human Health written by George E. Barreto and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-16 with Medical categories.


Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof.