Axonal Regeneration In The Central Nervous System

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Cajal S Degeneration And Regeneration Of The Nervous System

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Author : Santiago Ramón y Cajal
language : en
Publisher: History of Neuroscience
Release Date : 1991

Cajal S Degeneration And Regeneration Of The Nervous System written by Santiago Ramón y Cajal and has been published by History of Neuroscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.

This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and provides readers with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.

Indwelling Neural Implants

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Author : William M. Reichert
language : en
Publisher: CRC Press
Release Date : 2007-12-17

Indwelling Neural Implants written by William M. Reichert and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-17 with Medical categories.

Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel

Axonal Regeneration In The Central Nervous System

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Author : Nicholas A Ingoglia
language : en
Publisher: CRC Press
Release Date : 2000-09-29

Axonal Regeneration In The Central Nervous System written by Nicholas A Ingoglia and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-29 with Medical categories.

Summarizing a review of research into factors that regulate, stimulate, and prevent regeneration in the central nervous system (CNS), this comprehensive reference progresses further into answering and resolving neuron capacity for axon regeneration in the mammalian CNS. Axonal Regeneration in the Central Nervous System analyzes axonal regeneration, reinnervation, and functional recovery in lower vertebrates examines the correlation between developmental age and the ability to regenerate considers mammalian neuron responses at the cell body, site of injury, and in the distal nerve, including apoptic cell death, and inflammatory and glial responses to injury reviews genomic responses to axotomy with a comparative description of transcribed genes from successfully regenerating neurons and neurons incapable of regrowth discusses how growing axons may induce the expression of genes in glia/Schwann cells following axotomy and regeneration describes the use of gene therapy to deliver trophic and survival factors to injured neurons explores the hospitable environments of the peripheral nerve, olfactory ensheathing cells, and fetal cell transplants for regeneration discusses results from applications of fetal CNS tissue to human spinal cord injuries and much more!

Axonal Regeneration In The Mammalian Central Nervous System

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Author : Dorothy E. Oorschot
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Axonal Regeneration In The Mammalian Central Nervous System written by Dorothy E. Oorschot and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.

Mechanisms Of Axonal Regeneration In The Central Nervous System

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Author : Gunnar Heiko Dirk Poplawski
language : en
Publisher:
Release Date : 2014

Mechanisms Of Axonal Regeneration In The Central Nervous System written by Gunnar Heiko Dirk Poplawski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

The regenerative capacity of central nervous system (CNS) axons after injury is severely impaired compared to axons of the peripheral nervous system (PNS). We hypothesized that mechanisms both intrinsic and extrinsic to the neuron influence the ability of CNS axons to regenerate. To investigate this hypothesis we explored two model systems. In the first model system, we identified a regeneration transcriptome in injured corticospinal motor neurons that is associated with enhanced central axon regeneration after spinal cord injury. The genetic mechanisms identified in this model include cAMP-Erk-CREB, Huntingtin, NFE2L2, ephrin and semaphorin signaling, and provide a dataset for potential therapeutic intervention to improve axonal regeneration in vivo after spinal cord injury. In the second model, we tested the hypothesis that glial cells of the peripheral nerve, Schwann cells, are an essential mechanism contributing to central axonal regeneration after "conditioning" lesions, wherein injury to the peripheral branch of a dorsal root ganglion sensory neuron enhances regeneration of the central branch of the sensory neuron. The gene encoding Low-density lipoprotein Receptor-related Protein-1 (LRP1) was conditionally deleted in Schwann cells, impairing the survival and function of Schwann cells after injury; animals with Schwann cell-specific deletion of LRP1 exhibited a significant reduction in axon regeneration in vitro and a trend towards central sensory axon regeneration after conditioning lesions, confirming that glial cells exhibit an essential but partial role in supporting axonal regeneration. Overall, these studies identify novel molecular and cellular mechanisms that influence central axon regeneration, and suggest therapeutic approaches to improve neural repair after CNS injury.

Neuronal Development And Degeneration

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Author : Wenbo Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-23

Neuronal Development And Degeneration written by Wenbo Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-23 with categories.

Regenerative Biology And Medicine

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Author : David L. Stocum
language : en
Publisher: Elsevier
Release Date : 2010-07-26

Regenerative Biology And Medicine written by David L. Stocum and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-26 with Science categories.

The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the reader with an overview of the basic and clinically-oriented research that is being done. Not only does the content cover a plethora tissues and systems, it also includes information about the developmental plasticity of adult stem cells and the regeneration of appendages.As part of its balanced presentation, Regenerative Biology and Medicine does address the biological/bioethical issues and challanges involved in the new and exciting field of regenerative biology and medicine. *Tissues covered include skin, hair, teeth, cornea, and central neural types*Systems presented are digestive, respiratory, urogenital, musculoskeletal, and cardiovascular*Includes amphibians as powerful research models*Discusses appendage regeneration in amphibians and mammals

Myelin Mediated Inhibition Of Axonal Regeneration Past Present And Future

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Author : Sari Hannila
language : en
Publisher: Frontiers Media SA
Release Date : 2017-07-06

Myelin Mediated Inhibition Of Axonal Regeneration Past Present And Future written by Sari Hannila and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-06 with categories.

Pioneering studies conducted in the 1980’s laid the foundation for the hypothesis that axonal regeneration is limited by CNS myelin, and the identification of myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein (OMgp) as inhibitors of neurite outgrowth firmly established myelin as a key factor in regenerative failure. Mechanistically, it has been shown that MAG, Nogo, and OMgp mediate inhibition by binding to either Nogo receptor (NgR) or paired immunoglobulin receptor B (PirB), and initiating a signaling cascade that culminates in the activation of RhoA. Since the discovery of these proteins, there has been tremendous interest in identifying compounds and molecular mechanisms that are capable of overcoming myelin-mediated inhibition. Many studies have focused on pharmacological antagonism of receptors and signaling intermediates, while others have sought to identify and enhance endogenous pro-regenerative pathways. The most notable example of the latter is the conditioning lesion effect, which led to the discovery of cyclic AMP’s ability to overcome inhibition by MAG and myelin. Many of the agents tested in these studies have been shown to promote axonal regeneration in vivo, and this research topic allows researchers to share information about new treatments that have been developed in both academia and industry. As we look toward the future, it is becoming increasingly clear that reversal of myelin-mediated inhibition alone will not be sufficient to produce functional recovery from spinal cord injury, and that other factors, such as astroglial scarring, the expression of chondroitin sulfate proteoglycans, neuronal cell death, and lack of neurotrophic support, must also be taken into consideration. Combinatorial approaches therefore hold a great deal of promise, and we hope to initiate a dialogue on how stem cell transplantation, chondroitinase ABC, gene therapy, growth-promoting agents, and other methods can be combined to optimize functional recovery. We introduce this topic in honor of the life and work of Dr. Marie T. Filbin (1955-2014). Through these articles, we highlight past achievements in the field, novel findings, unanswered questions and innovative ideas that we hope will lead to new advances in axonal regeneration.

Axonal Regeneration In The Mammalian Central Nervous System

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Author : Dorothy E Oorschot
language : en
Publisher:
Release Date : 1990-04-20

Axonal Regeneration In The Mammalian Central Nervous System written by Dorothy E Oorschot and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-04-20 with categories.

Proteomics Multi Omics And Systems Biology In Optic Nerve Regeneration

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Author : Sanjoy K. Bhattacharya
language : en
Publisher: Elsevier
Release Date : 2025-01-28

Proteomics Multi Omics And Systems Biology In Optic Nerve Regeneration written by Sanjoy K. Bhattacharya and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-28 with Science categories.

Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration is a comprehensive reference that covers all vistas of standardization of axon regeneration, as well as all multi-omics and system level data and integration tools. By adopting a translational approach, the book bridges current research in the field to clinical applications, and readers can expect to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, multiple dataset integrative tools, pathway convergence approaches and tools, outcome and outcome measures that unify bench research with clinical outcome.The axon regeneration from existing neurons in central nervous system (CNS) have become a potential possibility in the last decade. The potential possibility of long-distance axon growth has opened the possibility of re-connectivity of axons of retinal ganglion cell neurons within the lateral geniculate nucleus in the brain. The long-distance axon regeneration and re-connectivity is a promise to restore lost vision in the optic nerve. Further, long-distance regeneration and re-innervation is equally helpful for other fields such as spinal cord injuries. - Includes updates on the use of multi-omics datasets for selecting molecules for axon regeneration - Bridges the preclinical and clinical world, from selection of the molecules to outcome leading to IND filing and their use - Includes system level knowledge needed for central nervous system axon and dendrite regeneration, and standardizes the system level biology for axon regeneration - Explores the current state of multi-omics in axon and dendrite regeneration in the optic nerve and its comparison to other CNS regeneration