Axonal Regeneration In The Central Nervous System
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Axonal Regeneration In The Central Nervous System
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Author : Nicholas A Ingoglia
language : en
Publisher: CRC Press
Release Date : 2000-09-29
Axonal Regeneration In The Central Nervous System written by Nicholas A Ingoglia and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-29 with Medical categories.
Summarizing a review of research into factors that regulate, stimulate, and prevent regeneration in the central nervous system (CNS), this comprehensive reference progresses further into answering and resolving neuron capacity for axon regeneration in the mammalian CNS. Axonal Regeneration in the Central Nervous System analyzes axonal regeneration, reinnervation, and functional recovery in lower vertebrates examines the correlation between developmental age and the ability to regenerate considers mammalian neuron responses at the cell body, site of injury, and in the distal nerve, including apoptic cell death, and inflammatory and glial responses to injury reviews genomic responses to axotomy with a comparative description of transcribed genes from successfully regenerating neurons and neurons incapable of regrowth discusses how growing axons may induce the expression of genes in glia/Schwann cells following axotomy and regeneration describes the use of gene therapy to deliver trophic and survival factors to injured neurons explores the hospitable environments of the peripheral nerve, olfactory ensheathing cells, and fetal cell transplants for regeneration discusses results from applications of fetal CNS tissue to human spinal cord injuries and much more!
Mechanisms Of Axonal Regeneration In The Central Nervous System
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Author : Gunnar Heiko Dirk Poplawski
language : en
Publisher:
Release Date : 2014
Mechanisms Of Axonal Regeneration In The Central Nervous System written by Gunnar Heiko Dirk Poplawski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
The regenerative capacity of central nervous system (CNS) axons after injury is severely impaired compared to axons of the peripheral nervous system (PNS). We hypothesized that mechanisms both intrinsic and extrinsic to the neuron influence the ability of CNS axons to regenerate. To investigate this hypothesis we explored two model systems. In the first model system, we identified a regeneration transcriptome in injured corticospinal motor neurons that is associated with enhanced central axon regeneration after spinal cord injury. The genetic mechanisms identified in this model include cAMP-Erk-CREB, Huntingtin, NFE2L2, ephrin and semaphorin signaling, and provide a dataset for potential therapeutic intervention to improve axonal regeneration in vivo after spinal cord injury. In the second model, we tested the hypothesis that glial cells of the peripheral nerve, Schwann cells, are an essential mechanism contributing to central axonal regeneration after "conditioning" lesions, wherein injury to the peripheral branch of a dorsal root ganglion sensory neuron enhances regeneration of the central branch of the sensory neuron. The gene encoding Low-density lipoprotein Receptor-related Protein-1 (LRP1) was conditionally deleted in Schwann cells, impairing the survival and function of Schwann cells after injury; animals with Schwann cell-specific deletion of LRP1 exhibited a significant reduction in axon regeneration in vitro and a trend towards central sensory axon regeneration after conditioning lesions, confirming that glial cells exhibit an essential but partial role in supporting axonal regeneration. Overall, these studies identify novel molecular and cellular mechanisms that influence central axon regeneration, and suggest therapeutic approaches to improve neural repair after CNS injury.
Degeneration And Regeneration In The Nervous System
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Author : Norman Saunders
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Degeneration And Regeneration In The Nervous System written by Norman Saunders and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Medical categories.
Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.
Axonal Regeneration In The Mammalian Central Nervous System
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Author : Dorothy E. Oorschot
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Axonal Regeneration In The Mammalian Central Nervous System written by Dorothy E. Oorschot and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.
Axonal Regeneration In The Mammalian Central Nervous System
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Author : Dorothy E Oorschot
language : en
Publisher:
Release Date : 1990-04-20
Axonal Regeneration In The Mammalian Central Nervous System written by Dorothy E Oorschot and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-04-20 with categories.
Axon Growth And Regeneration Part 1
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Axon Growth And Regeneration Part 1 written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding Axon Growth and Regeneration. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Axonal Regeneration In The Central Nervous System Of Amphibians And Reptiles
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Author : Dirk M. Lang
language : de
Publisher:
Release Date : 1996
Axonal Regeneration In The Central Nervous System Of Amphibians And Reptiles written by Dirk M. Lang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Axonal Regeneration In The Mammalian Central Nervous System
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Author : Christian Brösamle
language : en
Publisher:
Release Date : 1998
Axonal Regeneration In The Mammalian Central Nervous System written by Christian Brösamle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Special Issue
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Author :
language : en
Publisher:
Release Date : 2008
Special Issue written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Nerve Organ And Tissue Regeneration Research Perspectives
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Author : Fredrick Seil
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Nerve Organ And Tissue Regeneration Research Perspectives written by Fredrick Seil and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Nerve, Organ, and Tissue Regeneration: Research Perspectives presents the proceedings of a symposium held in Harpers Ferry, West Virginia, on September 21–24, 1982. This book explores the neural and nonneural areas of regeneration, with emphasis on the nervous system. Organized into six parts encompassing 22 chapters, this compilation of papers examines the commitment of the Veterans Administration to deal with the clinical problem of spinal cord injury by establishing 19spinal cord injury treatment and rehabilitation centers throughout the United States. This book then discusses the characteristics of the neuronal response to axon injury, which vary from cellular hypertrophy and heightened metabolism to cell death. Other chapters consider the three phases of axonal regeneration, including sprout formation, elongation, and maturation. The final chapter deals with the structural and functional alterations that developed when the length of the mammalian intestine is shortened by excision or by-pass of a long segment. This book is a valuable resource for biologists, orthopedic surgeons, and neuroscientists.