Mechanisms Of Axonal Regeneration In The Central Nervous System
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Mechanisms Of Axonal Regeneration In The Central Nervous System
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Author : Gunnar Heiko Dirk Poplawski
language : en
Publisher:
Release Date : 2014
Mechanisms Of Axonal Regeneration In The Central Nervous System written by Gunnar Heiko Dirk Poplawski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
The regenerative capacity of central nervous system (CNS) axons after injury is severely impaired compared to axons of the peripheral nervous system (PNS). We hypothesized that mechanisms both intrinsic and extrinsic to the neuron influence the ability of CNS axons to regenerate. To investigate this hypothesis we explored two model systems. In the first model system, we identified a regeneration transcriptome in injured corticospinal motor neurons that is associated with enhanced central axon regeneration after spinal cord injury. The genetic mechanisms identified in this model include cAMP-Erk-CREB, Huntingtin, NFE2L2, ephrin and semaphorin signaling, and provide a dataset for potential therapeutic intervention to improve axonal regeneration in vivo after spinal cord injury. In the second model, we tested the hypothesis that glial cells of the peripheral nerve, Schwann cells, are an essential mechanism contributing to central axonal regeneration after "conditioning" lesions, wherein injury to the peripheral branch of a dorsal root ganglion sensory neuron enhances regeneration of the central branch of the sensory neuron. The gene encoding Low-density lipoprotein Receptor-related Protein-1 (LRP1) was conditionally deleted in Schwann cells, impairing the survival and function of Schwann cells after injury; animals with Schwann cell-specific deletion of LRP1 exhibited a significant reduction in axon regeneration in vitro and a trend towards central sensory axon regeneration after conditioning lesions, confirming that glial cells exhibit an essential but partial role in supporting axonal regeneration. Overall, these studies identify novel molecular and cellular mechanisms that influence central axon regeneration, and suggest therapeutic approaches to improve neural repair after CNS injury.
Cajal S Degeneration And Regeneration Of The Nervous System
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Author : Santiago Ramón y Cajal
language : en
Publisher: History of Neuroscience
Release Date : 1991
Cajal S Degeneration And Regeneration Of The Nervous System written by Santiago Ramón y Cajal and has been published by History of Neuroscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and provides readers with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.
Mechanisms Of Neuronal Recovery In The Central Nervous System
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Author : Luis B. Tovar-y-Romo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-13
Mechanisms Of Neuronal Recovery In The Central Nervous System written by Luis B. Tovar-y-Romo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-13 with Science categories.
Apoptosis And Beyond
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Author : James A. Radosevich
language : en
Publisher: John Wiley & Sons
Release Date : 2018-09-18
Apoptosis And Beyond written by James A. Radosevich and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-18 with Science categories.
These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.
Indwelling Neural Implants
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Author : William M. Reichert
language : en
Publisher: CRC Press
Release Date : 2007-12-17
Indwelling Neural Implants written by William M. Reichert and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-17 with Medical categories.
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
Axonal Regeneration In The Mammalian Central Nervous System
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Author : Dorothy E. Oorschot
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Axonal Regeneration In The Mammalian Central Nervous System written by Dorothy E. Oorschot and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.
Advances In Cns Repair Regeneration And Neuroplasticity From Basic Mechanisms To Therapeutic Strategies
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Author : Shuxin Li
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-09
Advances In Cns Repair Regeneration And Neuroplasticity From Basic Mechanisms To Therapeutic Strategies written by Shuxin Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Science categories.
Neuronal Development And Degeneration
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Author : Wenbo Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-23
Neuronal Development And Degeneration written by Wenbo Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-23 with categories.
Mechanisms Of Axonal Regeneration After Central Nervous System Injury
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Author : Rita Juneja
language : en
Publisher:
Release Date : 2012
Mechanisms Of Axonal Regeneration After Central Nervous System Injury written by Rita Juneja and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Central nervous system categories.
Cellular Migration And Formation Of Axons And Dendrites
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Author : Bin Chen
language : en
Publisher: Academic Press
Release Date : 2020-05-29
Cellular Migration And Formation Of Axons And Dendrites written by Bin Chen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-29 with Medical categories.
Cellular Migration and Formation of Neuronal Connections, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. This book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites and cellular migration. - Features leading experts in various subfields as section editors and article authors - Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship - Includes coverage of mechanisms which regulate the formation of axons and dendrites and cellular migration - Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity