Mechanisms Of Axonal Regeneration In The Central Nervous System
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Mechanisms Of Axonal Regeneration In The Central Nervous System
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Author : Gunnar Heiko Dirk Poplawski
language : en
Publisher:
Release Date : 2014
Mechanisms Of Axonal Regeneration In The Central Nervous System written by Gunnar Heiko Dirk Poplawski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
The regenerative capacity of central nervous system (CNS) axons after injury is severely impaired compared to axons of the peripheral nervous system (PNS). We hypothesized that mechanisms both intrinsic and extrinsic to the neuron influence the ability of CNS axons to regenerate. To investigate this hypothesis we explored two model systems. In the first model system, we identified a regeneration transcriptome in injured corticospinal motor neurons that is associated with enhanced central axon regeneration after spinal cord injury. The genetic mechanisms identified in this model include cAMP-Erk-CREB, Huntingtin, NFE2L2, ephrin and semaphorin signaling, and provide a dataset for potential therapeutic intervention to improve axonal regeneration in vivo after spinal cord injury. In the second model, we tested the hypothesis that glial cells of the peripheral nerve, Schwann cells, are an essential mechanism contributing to central axonal regeneration after "conditioning" lesions, wherein injury to the peripheral branch of a dorsal root ganglion sensory neuron enhances regeneration of the central branch of the sensory neuron. The gene encoding Low-density lipoprotein Receptor-related Protein-1 (LRP1) was conditionally deleted in Schwann cells, impairing the survival and function of Schwann cells after injury; animals with Schwann cell-specific deletion of LRP1 exhibited a significant reduction in axon regeneration in vitro and a trend towards central sensory axon regeneration after conditioning lesions, confirming that glial cells exhibit an essential but partial role in supporting axonal regeneration. Overall, these studies identify novel molecular and cellular mechanisms that influence central axon regeneration, and suggest therapeutic approaches to improve neural repair after CNS injury.
Mechanisms Of Axonal Regeneration After Central Nervous System Injury
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Author : Rita Juneja
language : en
Publisher:
Release Date : 2012
Mechanisms Of Axonal Regeneration After Central Nervous System Injury written by Rita Juneja and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Central nervous system categories.
Degeneration And Regeneration In The Nervous System
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Author : Norman Saunders
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Degeneration And Regeneration In The Nervous System written by Norman Saunders and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Medical categories.
Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.
Mechanisms Of Neuronal Recovery In The Central Nervous System
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Author : Luis B. Tovar-y-Romo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-13
Mechanisms Of Neuronal Recovery In The Central Nervous System written by Luis B. Tovar-y-Romo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-13 with Science categories.
The Regeneration Of Nerves And Spinal Cord
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Author : Lars P. Klimaschewski
language : en
Publisher: Springer Nature
Release Date :
The Regeneration Of Nerves And Spinal Cord written by Lars P. Klimaschewski and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Signaling Mechanisms Limiting Axon Regeneration In The Adult Central Nervous System
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Author : Glenn Chung-Wing Yiu
language : en
Publisher:
Release Date : 2006
Signaling Mechanisms Limiting Axon Regeneration In The Adult Central Nervous System written by Glenn Chung-Wing Yiu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Axons categories.
Together, the results in this dissertation provide novel insights into the molecular mechanisms mediating the inhibitory effects of the adult glial environment. Future studies employing combinatorial approaches to target both extrinsic and intrinsic mechanisms that limit adult CNS regeneration will be imperative toward developing therapies for neural injury.
Axon Growth And Regeneration Part 1
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Axon Growth And Regeneration Part 1 written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding Axon Growth and Regeneration. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Axonal Regeneration In The Central Nervous System
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Author : Nicholas A Ingoglia
language : en
Publisher: CRC Press
Release Date : 2000-09-29
Axonal Regeneration In The Central Nervous System written by Nicholas A Ingoglia and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-29 with Medical categories.
Summarizing a review of research into factors that regulate, stimulate, and prevent regeneration in the central nervous system (CNS), this comprehensive reference progresses further into answering and resolving neuron capacity for axon regeneration in the mammalian CNS. Axonal Regeneration in the Central Nervous System analyzes axonal regeneration, reinnervation, and functional recovery in lower vertebrates examines the correlation between developmental age and the ability to regenerate considers mammalian neuron responses at the cell body, site of injury, and in the distal nerve, including apoptic cell death, and inflammatory and glial responses to injury reviews genomic responses to axotomy with a comparative description of transcribed genes from successfully regenerating neurons and neurons incapable of regrowth discusses how growing axons may induce the expression of genes in glia/Schwann cells following axotomy and regeneration describes the use of gene therapy to deliver trophic and survival factors to injured neurons explores the hospitable environments of the peripheral nerve, olfactory ensheathing cells, and fetal cell transplants for regeneration discusses results from applications of fetal CNS tissue to human spinal cord injuries and much more!
The Role Of Microenvironment In Axonal Regeneration
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Author : Christine C. Stichel-Gunkel
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Role Of Microenvironment In Axonal Regeneration written by Christine C. Stichel-Gunkel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Since the pioneering studies of Ramon y Cajal the inability of lesioned adult CNS axons to regenerate has been well established. During the past years advancements in molecular, cellular and biochemical knowledge have provided new insights into the extrinsic mechanims underlying regeneration failure. The rapid progress in this field has already led to the development of new concepts for therapeutic manipulations. This book provides a comprehensive overview of structural and molecular changes induced by an invasive CNS lesion and their involvements in regeneration processes. Moreover, it demonstrates the strong growth-promoting actitivies of implanted glial cells. The data is discussed in relation to current knowledge on the mechanisms of axonal degeneration and regeneration and in terms of their relevance for the development of novel therapeutic strategies.
Wiring The Nervous System Mechanisms Of Axonal And Dendritic Remodelling In Health And Disease
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Author : Tracy S. Tran
language : en
Publisher: CRC Press
Release Date : 2024-01-31
Wiring The Nervous System Mechanisms Of Axonal And Dendritic Remodelling In Health And Disease written by Tracy S. Tran and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-31 with Science categories.
This book examines recent key findings on the mechanisms of axonal and dendritic remodeling in different model organisms. Each chapter is contributed by a panel of experts in their respective subfields of neurosciences, to provide and discuss the latest discoveries ranging from neuronal morphogenesis during development, experience-dependent structural plasticity, to neuronal degeneration, regeneration, and pathologies in neurological disorders. The process of neuronal remodeling, specifically their axons and dendrites, is essential for the proper wiring of the nervous system during early development and continues during postnatal ages to shape the pattern of synaptic connections throughout the life of the organism, including humans. Over recent years, substantial progress has been made in our understanding of the cellular and molecular mechanisms that control neuronal remodeling. In addition, there is accumulating evidence demonstrating how the nervous system could remodel in response to injury and in pathological conditions. Topics discussed in the book include: Axonal degeneration during development and in pathological or disease conditions Neuronal morphogenesis (axons and dendrites) Experience-dependent structural plasticity to synaptogenesis Dendrite degeneration and regeneration