Beta Amyloid From Physiology To Pathogenesis

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Beta Amyloid From Physiology To Pathogenesis

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Author : Robert A. Nichols
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-06

Beta Amyloid From Physiology To Pathogenesis written by Robert A. Nichols and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-06 with Science categories.

Physiology And Pathophysiology Of The Extracellular Calcium Sensing Receptor

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Author : Enikö Kallay
language : en
Publisher: Frontiers Media SA
Release Date : 2018-07-09

Physiology And Pathophysiology Of The Extracellular Calcium Sensing Receptor written by Enikö Kallay and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-09 with categories.

Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in calcium homeostasis such as parathyroid, kidney, and bone it regulates circulating calcium concentrations. The germline mutations of the CaSR cause parathyroid disorders demonstrating the importance of the CaSR for the maintenance of serum calcium homeostasis. The CaSR has an important role also in a range of non-calcitropic tissues, such as the intestine, lungs, central and peripheral nervous system, breast, skin and reproductive system, where it regulates molecular and cellular processes such as gene expression, proliferation, differentiation and apoptosis; as well as regulating hormone secretion and lactation. This Research Topic is an overview of the CaSR and its molecular signaling properties together with the various organ systems where it plays an important role. The articles highlight the current knowledge regarding many aspects of the calcitropic and non-calcitropic physiology and pathophysiology of the CaSR.

Biomedical Index To Phs Supported Research

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Author :
language : en
Publisher:
Release Date :

Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medicine categories.

Iron Physiology And Pathophysiology In Humans

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Author : Gregory J. Anderson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-16

Iron Physiology And Pathophysiology In Humans written by Gregory J. Anderson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-16 with Medical categories.

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

Biomedical Index To Phs Supported Research Pt A Subject Access A H

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Author :
language : en
Publisher:
Release Date : 1994

Biomedical Index To Phs Supported Research Pt A Subject Access A H written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medicine categories.

Physiological Study Of Presenilins And Baces Two Proteases Involved In The Pathogenesis Of Alzheimer S Disease

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Author : Jos Tournoy
language : en
Publisher: Leuven University Press
Release Date : 2006

Physiological Study Of Presenilins And Baces Two Proteases Involved In The Pathogenesis Of Alzheimer S Disease written by Jos Tournoy and has been published by Leuven University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.

Physiology And Pathology Of Neuroglia

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Author : Reyes-Haro
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-07

Physiology And Pathology Of Neuroglia written by Reyes-Haro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-07 with Science categories.

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Author :
language : en
Publisher: IOS Press
Release Date :

written by and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Biomarkers To Disentangle The Physiological From Pathological Brain Aging

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Author : F. G. Guerini
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-22

Biomarkers To Disentangle The Physiological From Pathological Brain Aging written by F. G. Guerini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-22 with categories.

Molecular Pathology Of Alzheimer S Disease

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Author : Rudy Castellani
language : en
Publisher: Biota Publishing
Release Date : 2013-10-01

Molecular Pathology Of Alzheimer S Disease written by Rudy Castellani and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-01 with Health & Fitness categories.

Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.