Physiology And Pathophysiology Of The Extracellular Calcium Sensing Receptor
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Physiology And Pathophysiology Of The Extracellular Calcium Sensing Receptor
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Author : Enikö Kallay
language : en
Publisher: Frontiers Media SA
Release Date : 2018-07-09
Physiology And Pathophysiology Of The Extracellular Calcium Sensing Receptor written by Enikö Kallay and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-09 with categories.
Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in calcium homeostasis such as parathyroid, kidney, and bone it regulates circulating calcium concentrations. The germline mutations of the CaSR cause parathyroid disorders demonstrating the importance of the CaSR for the maintenance of serum calcium homeostasis. The CaSR has an important role also in a range of non-calcitropic tissues, such as the intestine, lungs, central and peripheral nervous system, breast, skin and reproductive system, where it regulates molecular and cellular processes such as gene expression, proliferation, differentiation and apoptosis; as well as regulating hormone secretion and lactation. This Research Topic is an overview of the CaSR and its molecular signaling properties together with the various organ systems where it plays an important role. The articles highlight the current knowledge regarding many aspects of the calcitropic and non-calcitropic physiology and pathophysiology of the CaSR.
Physiology And Pathophysiology Of The Extracellular Calcium Sensing Receptor
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Author :
language : en
Publisher:
Release Date : 2018
Physiology And Pathophysiology Of The Extracellular Calcium Sensing Receptor written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in calcium homeostasis such as parathyroid, kidney, and bone it regulates circulating calcium concentrations. The germline mutations of the CaSR cause parathyroid disorders demonstrating the importance of the CaSR for the maintenance of serum calcium homeostasis. The CaSR has an important role also in a range of non-calcitropic tissues, such as the intestine, lungs, central and peripheral nervous system, breast, skin and reproductive system, where it regulates molecular and cellular processes such as gene expression, proliferation, differentiation and apoptosis; as well as regulating hormone secretion and lactation. This Research Topic is an overview of the CaSR and its molecular signaling properties together with the various organ systems where it plays an important role. The articles highlight the current knowledge regarding many aspects of the calcitropic and non-calcitropic physiology and pathophysiology of the CaSR.
Calcium Sensing Receptor
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Author : Naibedya Chattopadhyay
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Calcium Sensing Receptor written by Naibedya Chattopadhyay and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Calcium-Sensing Receptor provides an overview of various aspects of the calcium receptor's biochemistry, physiology and pathophysiology that is suitable both for those who have been working in the field of Ca2+0-sensing as well as those who are new to this discipline. Calcium-Sensing Receptor is the nineteenth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.
Calcium Sensing Receptor
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Author : Daniela Riccardi
language : en
Publisher:
Release Date : 2004
Calcium Sensing Receptor written by Daniela Riccardi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
The Parathyroids
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Author : John P. Bilezikian
language : en
Publisher: Elsevier
Release Date : 2001-07-21
The Parathyroids written by John P. Bilezikian and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-21 with Medical categories.
Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians. Key Features * Offers objective and authoritative reviews on controversial clinical issues * Written by world experts on parathyroid hormone and its disorders * Superb, state-of-the-art compendium in one convenient volume * Bridges basic science of parathyroid hormone to major clinical disorders * Practical information on clinical management of parathyroid hormone disorders
The Evolutionary History Of The Extracellular Calcium Sensing Receptor And Its Role In Skeletal Development
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Author : Amanda Leigh Herberger
language : en
Publisher:
Release Date : 2013
The Evolutionary History Of The Extracellular Calcium Sensing Receptor And Its Role In Skeletal Development written by Amanda Leigh Herberger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
As one of the most interesting members of the G protein-coupled receptor (GPCR) superfamily of proteins, the calcium-sensing receptor (CaSR) is restricted in its presence to the chordate-vertebrate lineage, pointing to an interesting possible link between the evolutionary emergence of CaSR and of vertebrate-type mineralized skeleton, and, more generally to the vertebrate system for calcium homeostasis. My thesis is framed in the context of CaSR evolution from an ancestral glutamate receptor-like GPCR, and of adaptive changes in the receptor related to habitat. By employing molecular phylogenetic, genomic, evolutionary developmental (evo-devo), and physiological approaches, I explored the core hypothesis that CaSRs evolved contemporaneously with the evolution of vertebrate mineralized-skeletal tissues. I explored the hypothesis that the CaSR subgroup of family C GPCRs evolved as a result of adaptive evolution. Tests for evolutionary selection among CaSRs, and some CaSR-like proteins, overall, revealed strong purifying selection, along with evidence for adaptive selection among major vertebrate clades, suggesting these episodes of positive selection may be linked to the natural history and physiology of calcium homeostatic patterns in aquatic and terrestrial vertebrate groups. I explored the hypothesis that CaSR is essential for proper developmental skeletal morphogenesis. Experimental studies addressed gaps in early vertebrate CaSR knowledge by exploring, in an evo-devo context, the essential role of CaSRs in vertebrate bone biology using the zebrafish model system. The experimental findings demonstrated a dependence on CaSR for normal skeletal development and subsequent morphogenesis, and point to an important involvement of CaSR in bone biology in piscine vertebrates. On a larger scale, my studies signal the probable importance of this receptor in skeletal emergence and development early in chordate-vertebrate evolution. In the course of the work, I also sequenced a cDNA for CaSR in the elephant fish. That sequence was used in the phylogenetic analyses. I also constructed three-dimensional homology models of CaSR receptor proteins that supported the phylogenetic analyses and the tests of selection.
Calcium In Internal Medicine
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Author : Hirotoshi Morii
language : en
Publisher: Springer
Release Date : 2002-04-30
Calcium In Internal Medicine written by Hirotoshi Morii and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-30 with Medical categories.
Calcium plays an enormous and varied role in living systems now widely appreciated by clinicians. Calcium in Internal Medicine demonstrates the physiological significance of calcium in clinical medicine and discusses the abnormal calcium metabolism in disorders such as renal failure, hypertension, atherosclerosis and osteoporosis. Hirotoshi Morii (Editor) linked the clinical use of vitamin D analogues in bone diseases, Yoshiki Nishizawa (Editor) researched the connection between calcium metabolism and atherosclerosis and Shaul G. Massry (Editor) was the first to systematize the importance of excess PTH in chronic renal failure. In addition to these areas, Calcium in Internal Medicine covers basic physiology, pathophysiology, nutritional requirements and the role of calcium in the development and treatment of other various diseases. The importance of calcium and its regulatory systems is brought together in one publication providing a useful reference tool for internists, rheumatologists and endocrinologists.
Investigating The Role Of The Extracellular Calcium Sensing Receptor Casr In Vascular Pathophysiology Using A Novel Mouse Model Of Selective Ablation Of Casr From Mouse Vascular Smooth Muscle Cells
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Author : Thomas Davies
language : en
Publisher:
Release Date : 2013
Investigating The Role Of The Extracellular Calcium Sensing Receptor Casr In Vascular Pathophysiology Using A Novel Mouse Model Of Selective Ablation Of Casr From Mouse Vascular Smooth Muscle Cells written by Thomas Davies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Pediatric Nephrology
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Author : Ellis D. Avner
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-08-20
Pediatric Nephrology written by Ellis D. Avner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-20 with Medical categories.
Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.
New Perspectives In Magnesium Research
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Author : Yoshiki Nishizawa
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-03-06
New Perspectives In Magnesium Research written by Yoshiki Nishizawa and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-06 with Medical categories.
A definitive review in the field of magnesium research, this book brings together the proceedings of the 11th International Magnesium Symposium in Osaka, Japan from October 22-26, 2006. Written by authorities in the area, the book provides a thorough overview of progress in the area of magnesium research. The author is one of the world's foremost magnesium researchers and reviewers, and the book provides essential reading for researchers in magnesium.