Binding Phenomena
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Cell Surface Receptors A Short Course On Theory And Methods
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Author : Lee E. Limbird
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cell Surface Receptors A Short Course On Theory And Methods written by Lee E. Limbird and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition is a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying principles removes the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, the basic concepts become emphasized. This volume is a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed.
Polyelectrolytes
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Author : E. Sélégny
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Polyelectrolytes written by E. Sélégny and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book contains a number of articles inspired by the NATO Advanced Study Institute on 'Charged and Reactive Polymers l' held in France in June 1972. This general title indicates simply the intention of a series. The meeting dealt mainly with the fundamental problems of the physical chemistry of polyelectrolytes in solution. Some of the articles reproduce the lectures exactly as they were delivered. Some others have been modified to a greater or lesser extent, and this as a result of improvements or new inspiration arising from comments and discussions. In previous larger conferences on macromolecules, polyelectrolytes constituted only a marginal problem and few were the individual communications or short was the time al10tted to this subject. In other meetings of a biophysical character the uses of the techniques of charged macromolecules have been exposed with less attention given to the theories or to the creation or interpretation of these techniques. AU of us felt that the time had come to enumerate and to evaluate this increasing science of polyelectrolytes which has become of major interest. During the whole period of the Institute physical chemists discussed their mutual problems for more than a week, and of ten far into the night! One of the advantages of such an Institute is to enable the Directors and the mem bers of the Scientific Committee to establish a logical order in the lectures; this order has been respected in the present edition.
Cell Surface Receptors
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Author : Lee E. Limbird
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Cell Surface Receptors written by Lee E. Limbird and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
The purpose of this book is to serve as a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying prin ciples is intended to remove the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, it is hoped that the basic concepts can be emphasized. This book is meant to be a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed. I feit compelled to write this book for several reasons. The primary philosophical reason was to provide, in one volume, an overall perspective on the study ofcell surface receptors that describes their characterization from pharmacological studies in a whole organ or tissue bath (chapter 2) to studies of radioligand binding in isolated membrane and detergent-solubilized pre parations (chapters 3-5) and, back again, to studies in intact cells or tissues using morphological and biochemical techniques (chapter 6). It is my opinion that the ultimate understanding of the molecular basis for hormone or drug receptor interactions, and the physiological consequences of these inter actions, will require an assessment of cell surface receptor function at all of these experimental levels. In many cases an investigator may not choose to of investigation considered here.
Meaning Context And Methodology
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Author : Sarah-Jane Conrad
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2017-10-23
Meaning Context And Methodology written by Sarah-Jane Conrad and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-23 with Language Arts & Disciplines categories.
What methodological impact does Contextualism have on the philosophy of language? This collection sets out to provide some answers. The authors in this volume question three ultimately connected assumptions of the philosophy of language. The first assumption relates to the predominant status of referential semantics and its power to explain truth-conditional meaning. This assumption has come under attack by the context thesis and a number of papers pursue the question of whether this is justified. The second assumption gives priority to assertive sentences when considering language use. The context thesis changes our understanding of language use altogether; possible implications from this methodological shift are addressed in this volume. According to the third assumption, philosophical analysis amounts to nothing more than conceptual analysis. The context thesis risks undermining this project. Whether conceptual analysis can still be defended as a methodological tool is discussed in this volume.
Derivation And Explanation In The Minimalist Program
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Author : Samuel Epstein
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Derivation And Explanation In The Minimalist Program written by Samuel Epstein and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Language Arts & Disciplines categories.
Derivation and Explanation in the Minimalist Program presents accessible, cutting edge research on an enduring and fundamental question confronting all linguistic inquiry – the respective roles of derivation and representation. Presents accessible, cutting edge research on the respective roles of derivation and representation in syntactic inquiry. Discusses a wide range of phenomena and also includes alternative, representational perspectives. Features papers by M. Brody, C. Collins, S. Epstein, J. Frampton, S. Gutmann, N. Hornstein, R. Kayne, H. Kitahara, J. McCloskey, N. Richards, D. Seely, E. Torrego, J. Uriagereka, C.J.W. Zwart.
Neural Correlates Of Thinking
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Author : Eduard Kraft
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-14
Neural Correlates Of Thinking written by Eduard Kraft and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-14 with Science categories.
The advances in neuroimaging technologies have led to substantial progress in understanding the neural mechanisms of cognitive functions. Thinking and reasoning have only recently been addressed by using neuroimaging techniques. The present book comprehensively explores current approaches and contributions to understanding the neural mechanisms of thinking in a concise and readable manner. It provides an insight into the state of the art and the potentials, but also the limitations of current neuroimaging methods for studying cognitive functions. The book will be a valuable companion for everyone interested in one of the most fascinating topics of cognitive neuroscience.
Water Soluble Synthetic Polymers
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Author : Philip Molyneux
language : en
Publisher: CRC Press
Release Date : 2018-04-05
Water Soluble Synthetic Polymers written by Philip Molyneux and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-05 with Science categories.
Although several monographs and reviews have appeared on individual polymers of this type, and their applications and other technical aspects have also been discussed, this is apparently the first book to deal with the physical chemistry of water-soluble synthetic polymers as a group. This collective survey enables their properties and behaviour to be compared, and to be correlated with their molecular structures for predictive purposes. However, this has made it necessary to critically re-appraise much of the earlier fundamental work, so that current discussion of more recent work can be put on ta proper basis. Thus, of the 1800 or so references cited, the middle two-thirds related to the twenty-year period centred on about 1968. Nevertheless, sufficient key recent references have also been included so that the existing ‘state of the art is delineated.
A Pharmacology Primer
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Author : Terry P. Kenakin
language : en
Publisher: Academic Press
Release Date : 2018-10-26
A Pharmacology Primer written by Terry P. Kenakin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-26 with Medical categories.
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. - Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved - Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions - Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
Comparative Pharmacokinetics
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Author : Jim E. Riviere
language : en
Publisher: John Wiley & Sons
Release Date : 2011-01-14
Comparative Pharmacokinetics written by Jim E. Riviere and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-14 with Medical categories.
Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.
A Pharmacology Primer
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Author : Terrence P. Kenakin
language : en
Publisher: Gulf Professional Publishing
Release Date : 2004
A Pharmacology Primer written by Terrence P. Kenakin and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
This guide has been designed especially for scientists trained in molecular biology and related fields who now need to know more about the basic theories, principles and practical applications of pharmacology.