Bioassays


Bioassays
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Pharmaceutical Bioassays


Pharmaceutical Bioassays
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Author : Shiqi Peng
language : en
Publisher: John Wiley & Sons
Release Date : 2009-11-09

Pharmaceutical Bioassays written by Shiqi Peng and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-09 with Medical categories.


The definitive compendium of bioassay procedures and applications A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models. Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories. Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students. Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which: Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer’s, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity—a particularly significant consideration in the development of safe and tolerable medications Highlights clinically relevant methods, ideas, and techniques to support any ­pharmaceutical researcher Suggests guidelines and systems to enhance communication between ­pharmacologists, chemists, and biologists Provides an informative analysis of pharmaceutical bioassay technologies and lab applications



Bioassays With Arthropods


Bioassays With Arthropods
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Author : Jacqueline L. Robertson
language : en
Publisher: CRC Press
Release Date : 2007-06-14

Bioassays With Arthropods written by Jacqueline L. Robertson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-14 with Mathematics categories.


Providing clear examples of the use of state-of-the-art computer programs for analyses of bioassay data, Bioassays with Arthropods, Second Edition explains the statistical basis and analysis for each kind of quantal response bioassay. The first edition was a must-have reference for designing, conducting, and interpreting bioassays: this comp



Bioassay Methods In Natural Product Research And Drug Development


Bioassay Methods In Natural Product Research And Drug Development
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Author : Lars Bohlin
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-01-31

Bioassay Methods In Natural Product Research And Drug Development written by Lars Bohlin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-31 with Medical categories.


Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.



Short Term Bioassays In The Analysis Of Complex Environmental Mixtures Iv


Short Term Bioassays In The Analysis Of Complex Environmental Mixtures Iv
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Author : Michael Waters
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Short Term Bioassays In The Analysis Of Complex Environmental Mixtures Iv written by Michael Waters and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.


With this proceedings of the fourth symposium on complex mixtures, we continue to revise and extend our knowledge of genetic methods for the evaluation of chemical mixtures in the environment. The early chapters of this volume are devoted to new bioassay techniques that are directly applicable to the monitoring of environments contaminated with genotoxic chemicals. Microbiological methods have been further refined to meet the special needs of atmospheric monitoring so that very small samples may now be efficiently tested. New in situ methods utilizing green plants actually avoid many of the usual difficulties of sample collection and preparation and offer special advantages in monitoring wastewater, sludges, and hazardous wastes. Insects also are being employed very effectively in the evaluation of gaseous air pollutants in controlled laboratory investigations. Increased emphasis has been placed on a comprehensive assessment of the potential of complex mixtures t9 cause various kinds of genetic damage. New assays for chromosome structural and numerical aberrations in mammalian cells in vitro have been developed and are being applied in laboratory studies. Efforts to link tests for gene mutation and cell transformation in vitro with assays for tumorigenesis in vivo are contributing to the validation of the short-term testing approach. Studies comparing in vitro and in vivo data on a coal conversion by-product, on polycyclic aromatic hydrocarbons, and on mineral fibers are reported in separate papers. Later chapters are devoted to investigations on the fractionation and biological evaluation of specific chemical components within complex mixtures.



Bioassays


Bioassays
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Author : Donat Hader
language : en
Publisher: Elsevier
Release Date : 2017-10-27

Bioassays written by Donat Hader and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-27 with Science categories.


Bioassays: Advanced Methods and Applications provides a thorough understanding of the applications of bioassays in monitoring toxicity in aquatic ecosystems. It reviews the newest tests and applications in discovering compounds and toxins in the environment, covering all suitable organisms, from bacteria, to microorganisms, to higher plants, including invertebrates and vertebrates. By learning about newer tests, water pollution control testing can be less time and labor consuming, and less expensive. This book will be helpful for anyone working in aquatic environments or those who need an introduction to ecotoxicology or bioassays, from investigators, to technicians and students. Features chapters written by internationally renowned researchers in the field, all actively involved in the development and application of bioassays Gives the reader an understanding of the advantages and deficiencies of available tests Addresses the problem of understanding the impact of toxins in an aquatic environment and how to assess them



Bioassays With Arthropods


Bioassays With Arthropods
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Author : Jacqueline L. Robertson
language : en
Publisher: CRC Press
Release Date : 2017-06-26

Bioassays With Arthropods written by Jacqueline L. Robertson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-26 with Mathematics categories.


Imagine a statistics book for bioassays written by a statistician. Next, imagine a statistics book for bioassays written for a layman. Bioassays with Arthropods, Third Edition offers the best of both worlds by translating the terse, precise language of the statistician into language used by the laboratory scientist. The book explains the statistical basis and analysis for each kind of quantal response bioassay in just the right amount of detail. The first two editions were a great reference for designing, conducting, and interpreting bioassays: this completely revised and updated third edition will also train the laboratory scientist to be an expert in estimation of dose response curves. New in the Third Edition: Introduces four new Windows and Apple-based computer programs (PoloJR, OptiDose, PoloMixture and PoloMulti) for the analyses of binary and multiple response analyses, respectively Replaces out-of-date GLIM examples with R program samples Includes a new chapter, Population Toxicology, and takes a systems approach to bioassays Expands the coverage of invasive species and quarantine statistics Building on the foundation set by the much-cited first two editions, the authors clearly delineate applications and ideas that are exceptionally challenging for those not already familiar with their use. They lead you through the methods with such ease and organization, that you suddenly find yourself readily able to apply concepts that you never thought you would understand. To order the PoloSuite computer software described in Bioassays with Arthropods, Third Edition, use the order form found at www.leora-software.com or contact the LeOra Software Company at [email protected].



Analytical Electrogenerated Chemiluminescence


Analytical Electrogenerated Chemiluminescence
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Author : Neso Sojic
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-11-19

Analytical Electrogenerated Chemiluminescence written by Neso Sojic and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-19 with Science categories.


Electrogenerated chemiluminescence (ECL) is a powerful and versatile analytical technique, which is widely applied for biosensing and successfully commercialized in the healthcare diagnostic market. After introducing the fundamental concepts, this book will highlight the recent analytical applications with a special focus on immunoassays, genotoxicity, imaging, DNA and enzymatic assays. The topic is clearly at the frontier between several scientific domains involving analytical chemistry, electrochemistry, photochemistry, materials science, nanoscience and biology. This book is ideal for graduate students, academics and researchers in industry looking for a comprehensive guide to the different aspects of electrogenerated chemiluminescence.



Aquatic Invertebrate Bioassays


Aquatic Invertebrate Bioassays
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Author : Arthur L. Buikema
language : en
Publisher: ASTM International
Release Date : 1980-12

Aquatic Invertebrate Bioassays written by Arthur L. Buikema and has been published by ASTM International this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-12 with Medical categories.




Statistical Techniques In Bioassay


Statistical Techniques In Bioassay
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Author : Z. Govindarajulu
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2001

Statistical Techniques In Bioassay written by Z. Govindarajulu and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Science categories.


In the face of the ever-increasing importance of statistical methods in medical research and practice, the first edition of this publication has provided a sound and deep understanding of statistical methods in bioassay to many students and researchers. In addition to the profound presentation of statistical methods of the first edition, here the reader will find new material stemming from the recent statistical literature as well as data reflecting modern trends in general applied statistical research. Examples are discussions on design and planning, e.g. choices of dose levels, and additional section in the chapter on Bayes methods, and a new chapter on sequential estimation for the logistic model. The book will be a valuable source of information to students in the experimental area of statistical aspects of biological assay, professional statisticians with an interest in research in this topic, teachers in statistics and biology, and investigators in the biological and medical sciences who use bioassay in their work.



Bioassays In Experimental And Preclinical Pharmacology


Bioassays In Experimental And Preclinical Pharmacology
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Author : Karuppusamy Arunachalam
language : en
Publisher:
Release Date : 2021

Bioassays In Experimental And Preclinical Pharmacology written by Karuppusamy Arunachalam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Biological assay categories.


This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.