Biocatalytic Production Of Amino Acids And Derivatives

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Biocatalytic Production Of Amino Acids And Derivatives

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Author : J. David Rozzell
language : en
Publisher:
Release Date : 1992-01-01

Biocatalytic Production Of Amino Acids And Derivatives written by J. David Rozzell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-01 with Amino acids categories.

Biocatalytic Productions Of Amino Acids And Derivatives

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Author : David Rozzell
language : en
Publisher:
Release Date : 1992-01-01

Biocatalytic Productions Of Amino Acids And Derivatives written by David Rozzell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-01 with categories.

Biocatalytic Preparation Of Amino Acids

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Author : Vivek Kothari
language : en
Publisher: Daya Books
Release Date : 2007

Biocatalytic Preparation Of Amino Acids written by Vivek Kothari and has been published by Daya Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Amino acids categories.

Amino Acids Are The Molecular Units That Make Up Proteins. All Proteins Are Various Compositions Of Twenty Specific Naturally Occurring Amino Acids. Amino Acids Are Found In All Foods Except Oil. There Are About Eighty Amino Acids Found In Nature, But Only Twenty To Twenty-Nine Are Required For Human Growth. Amino Acids Play A Pivotal Role In Living Systems, And Therefore Synthetic Amino Acids Have Been Of Significant Interest To Researchers Working Towards The Understanding And Modification Of Physiological Processes. Currently, The Amino Acids Used In Amino Acid Products Are Mainly Manufactured By Biocatalytic Methods. The Book Presents Detailed Discussion Of The Preparation Of Amino Acids By Biocatalysis. It Provides Examples Of Recently Developed Biocatalytic Methods For The Production Of Amino Acids And Its Derivatives. It Offers Upper Level Students And Professionals An Essential Resource For Pharmaceutical Development, Medicinal Chemistry And Biochemistry. Contents Chapter 1: Basics Of Biocatalysis; Chapter 2: Production Of Amino Acids; Chapter 3: Asymmetric Synthesis Of Amino Acids; Chapter 4: Amino Acids And Derivatives; Chapter 5: Strategies For Efficient Biocatalysis; Chapter 6: Synthesis Of Cage Amino Acids; Chapter 7: Types Of B-Amino Acids; Chapter 8: Extremophiles And Extremozymes; Chapter 9: Immobilised Enzymes; Chapter 10: Enzymatic Peptide Synthesis; Chapter 11: Synthesis Of Enantiomerically Pure (S)-Amino Acids And (R)-Amines; Chapter 12: Cloning And Sequence Analysis; Chapter 13: Bioseparation And Biocatalytic Applications.

Engineering Aminotransferases For The Biocatalytic Production Of Aromatic D Amino Acids

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Author : Curtis James William Walton
language : en
Publisher:
Release Date : 2018

Engineering Aminotransferases For The Biocatalytic Production Of Aromatic D Amino Acids written by Curtis James William Walton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

Optically pure aromatic D-amino acids, such as D-phenylalanine (D-Phe) and its derivatives, are high-value building blocks for the pharmaceutical industry. These compounds can be prepared using biocatalytic methods relying on various enzymes, including aminotransferases (ATs). ATs, also called transaminases (EC 2.6.1.X), are a subclass of pyridoxal 5'-phosphate-dependent enzymes that catalyze the transfer of the amino group from a donor substrate to a ketone acceptor. Synthesis of optically-pure amino acids using whole-cell biocatalytic cascades based on ATs possess several advantages compared to traditional chemical methods, including excellent enantioselectivity and increased process and step efficiency, which is achieved through the catalysis of multiple steps in one-pot reactions without requirement for intermediate work-ups, cofactor recycling, or toxic metals. However, enzyme biocatalysts typically need to be engineered to alter their substrate specificity or to increase their catalytic efficiency, which has limited their industrial application. Therefore, to facilitate the engineering process of ATs broadly and to produce aromatic D-amino acids, we developed a high-throughput assay for the testing of a broad range of ATs against libraries of potential substrates, and developed a biocatalytic cascade to produce optically pure aromatic D-amino acids.

Catalytic And Biocatalytic Methods For The Efficient Synthesis Of Biologically Relevant Non Proteinogenic Amino Acids

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Author : Anke Lemke
language : en
Publisher: Cuvillier Verlag
Release Date : 2014-04-29

Catalytic And Biocatalytic Methods For The Efficient Synthesis Of Biologically Relevant Non Proteinogenic Amino Acids written by Anke Lemke and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-29 with Science categories.

Non-proteinogenic amino acids are often important constituents of biologically potent natural products. The synthesis of these amino acids is often time-consuming, non-trivial and not sustainable. Thus, the central topic of this work was the formation of unusual amino acid structures by biocatalytic and catalytic methods. For the elucidation of the biosynthetic pathway of Streptomyces-produced muraymycins and related natural products, a ‘biosynthetic tool kit’ was compiled and prepared. This does not only comprehend the completed synthesis of deuterium-labeled compounds, such as (3R)- and (3S)-3-hydroxy-[5-2H]-l-arginine and other potential intermediates with a nucleosidic structure, but it also includes the development of fermentation methodology including the possibility to detect the muraymycin derivatives by LC MS. Furthermore, different synthetic routes with catalytic key steps for the preparation of the non-proteinogenic amino acid enduracididine were investigated.

Discovery And Properties Of Enzymes For Biocatalytic Production Of Beta Amino Acids

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Author : Rijksuniversiteit Groningen
language : en
Publisher:
Release Date : 2014

Discovery And Properties Of Enzymes For Biocatalytic Production Of Beta Amino Acids written by Rijksuniversiteit Groningen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

Development Of Bioprocesses For The Production Of Biocatalysts Used In The Synthesis Of Amino Acids And Amines

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Author : Brian Hugh Wilson Griffin
language : en
Publisher:
Release Date : 2016

Development Of Bioprocesses For The Production Of Biocatalysts Used In The Synthesis Of Amino Acids And Amines written by Brian Hugh Wilson Griffin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

Research in to enzyme catalysis has enormously enriched the success of biological organic synthesis; particularly in the last decade, remarkable progress in biological catalysis has taken place leading to the application of enzymes to a wider extent in industrial processes. The benefits of establishing enzymes as industrial catalysts are founded on the need to develop a 'clean' and 'pure' technology which carry out isomer and region selective reactions; generate or transform pure isomers compared with racemic mixtures and produce pure compounds in comparison with mixtures of by-products often arising from conventional chemical synthesis. With the onset of molecular biology and genetics, the manufacturing of high value proteins in recombinant host cells has become commonplace; nevertheless, there needs to be a better understanding of the optimum conditions for the production of every recombinant protein. In this study, the over expression of an industrially important amine oxidase - D-Amino Acid Oxidase (DAAO) - was attempted using two different expression systems: Escherichia coli and Pichia pastoris in order to establish the optimum conditions for industrial production. Amine oxidases exhibit stereoselectivity; ergo they can theoretically be used for the deracemisation of nonopticallypure mixtures of amines leading to optically pure amines of high value.Furthermore, DAAO is involved in the production of 7-aminocephalosporanic acid (7-ACA) from cephalosporin c (CPC), which can be used in the synthesis of novel cephalosporin antibiotic derivatives. In order to accelerate development of these new antibiotics DAAO must be readily available. Overexpression of DAAO in E. coli was studied under varying experimental conditions in order to ascertain the best conditions for enzymatic activity whilst simultaneously investigating the variations between both defined and complex media to understand suitability for scale-up.Although E. coli is still regarded as the 'go to' organisms for initial laboratory scale up the methylotrophic yeast P. pastoris is considered an industrial workhorse for the production of recombinant proteins and thus the expression of DAAO was also investigated to ascertain how enzyme activities are affected by this expression system. Furthermore, the supplementation of media with different nutrient sources of varying complexity was investigated, as was the implementation of co-feeding inorder to improve carbon flux during recombinant protein production. Finally, the oxygen availability was investigated in order to gain important understandings on its effects on microbial physiology and DAAO activity.

Towards Industrial Production Of A Useful Biocatalyst For Amino Acid Synthesis

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Author : Oluwasola Okor
language : en
Publisher:
Release Date : 2005

Towards Industrial Production Of A Useful Biocatalyst For Amino Acid Synthesis written by Oluwasola Okor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Amino acids categories.

Biocatalysis

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Author : Andreas S. Bommarius
language : en
Publisher: John Wiley & Sons
Release Date : 2007-02-27

Biocatalysis written by Andreas S. Bommarius and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-27 with Science categories.

The whole range of biocatalysis, from a firm grounding in theoretical concepts to in-depth coverage of practical applications and future perspectives. The book not only covers reactions, products and processes with and from biological catalysts, but also the process of designing and improving such biocatalysts. One unique feature is that the fields of chemistry, biology and bioengineering receive equal attention, thus addressing practitioners and students from all three areas.

Modification Of Polymers

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Author : Charles E. Carraher
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Modification Of Polymers written by Charles E. Carraher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

The sheer volume of topics which could have been included under our general title prompted us to make some rather arbitrary decisions about content. Modification by irradiation is not included because the activity in this area is being treated elsewhere. We have chosen to emphasize chemical routes to modification and have striven to pre sent as balanced a representation of current activity as time and page count permit. Industrial applications, both real and potential, are included. Where appropriate, we have encouraged the contributors to include review material to help provide the reader with adequate context. The initial chapter is a review from a historical perspective of polymer modification and contains an extensive bibliography. The remainder of the book is divided into four general areas: Reactions and Preparation of Copolymers Reactions and Preparation of Block and Graft Copolymers Modification Through Condensation Reactions Applications The chemical modification of homopolymers such as polyvinylchlo ride, polyethylene, poly(chloroalkylene sulfides), polysulfones, poly chloromethylstyrene, polyisobutylene, polysodium acrylate, polyvinyl alcohol, polyvinyl chloroformate, sulfonated polystyrene; block and graft copolymers such as poly(styrene-block-ethylene-co-butylene block-styrene), poly(I,4-polybutadiene-block ethylene oxide), star chlorine-telechelic polyisobutylene, poly(isobutylene-co-2,3-dimethyl- 1,3-butadiene), poly(styrene-co-N-butylmethacrylate); cellulose, dex tran and inulin, is described.