Biocatalytic Productions Of Amino Acids And Derivatives

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Biocatalytic Productions Of Amino Acids And Derivatives

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Author : David Rozzell
language : en
Publisher:
Release Date : 1992-01-01

Biocatalytic Productions Of Amino Acids And Derivatives written by David Rozzell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-01 with categories.

Biocatalytic Production Of Amino Acids And Derivatives

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Author : J. David Rozzell
language : en
Publisher:
Release Date : 1992-01-01

Biocatalytic Production Of Amino Acids And Derivatives written by J. David Rozzell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-01 with Amino acids categories.

Biocatalytic Preparation Of Amino Acids

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Author : Vivek Kothari
language : en
Publisher: Daya Books
Release Date : 2007

Biocatalytic Preparation Of Amino Acids written by Vivek Kothari and has been published by Daya Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Amino acids categories.

Amino Acids Are The Molecular Units That Make Up Proteins. All Proteins Are Various Compositions Of Twenty Specific Naturally Occurring Amino Acids. Amino Acids Are Found In All Foods Except Oil. There Are About Eighty Amino Acids Found In Nature, But Only Twenty To Twenty-Nine Are Required For Human Growth. Amino Acids Play A Pivotal Role In Living Systems, And Therefore Synthetic Amino Acids Have Been Of Significant Interest To Researchers Working Towards The Understanding And Modification Of Physiological Processes. Currently, The Amino Acids Used In Amino Acid Products Are Mainly Manufactured By Biocatalytic Methods. The Book Presents Detailed Discussion Of The Preparation Of Amino Acids By Biocatalysis. It Provides Examples Of Recently Developed Biocatalytic Methods For The Production Of Amino Acids And Its Derivatives. It Offers Upper Level Students And Professionals An Essential Resource For Pharmaceutical Development, Medicinal Chemistry And Biochemistry. Contents Chapter 1: Basics Of Biocatalysis; Chapter 2: Production Of Amino Acids; Chapter 3: Asymmetric Synthesis Of Amino Acids; Chapter 4: Amino Acids And Derivatives; Chapter 5: Strategies For Efficient Biocatalysis; Chapter 6: Synthesis Of Cage Amino Acids; Chapter 7: Types Of B-Amino Acids; Chapter 8: Extremophiles And Extremozymes; Chapter 9: Immobilised Enzymes; Chapter 10: Enzymatic Peptide Synthesis; Chapter 11: Synthesis Of Enantiomerically Pure (S)-Amino Acids And (R)-Amines; Chapter 12: Cloning And Sequence Analysis; Chapter 13: Bioseparation And Biocatalytic Applications.

Catalytic And Biocatalytic Methods For The Efficient Synthesis Of Biologically Relevant Non Proteinogenic Amino Acids

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Author : Anke Lemke
language : en
Publisher: Cuvillier Verlag
Release Date : 2014-04-29

Catalytic And Biocatalytic Methods For The Efficient Synthesis Of Biologically Relevant Non Proteinogenic Amino Acids written by Anke Lemke and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-29 with Science categories.

Non-proteinogenic amino acids are often important constituents of biologically potent natural products. The synthesis of these amino acids is often time-consuming, non-trivial and not sustainable. Thus, the central topic of this work was the formation of unusual amino acid structures by biocatalytic and catalytic methods. For the elucidation of the biosynthetic pathway of Streptomyces-produced muraymycins and related natural products, a ‘biosynthetic tool kit’ was compiled and prepared. This does not only comprehend the completed synthesis of deuterium-labeled compounds, such as (3R)- and (3S)-3-hydroxy-[5-2H]-l-arginine and other potential intermediates with a nucleosidic structure, but it also includes the development of fermentation methodology including the possibility to detect the muraymycin derivatives by LC MS. Furthermore, different synthetic routes with catalytic key steps for the preparation of the non-proteinogenic amino acid enduracididine were investigated.

Development Of Bioprocesses For The Production Of Biocatalysts Used In The Synthesis Of Amino Acids And Amines

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Author : Brian Hugh Wilson Griffin
language : en
Publisher:
Release Date : 2016

Development Of Bioprocesses For The Production Of Biocatalysts Used In The Synthesis Of Amino Acids And Amines written by Brian Hugh Wilson Griffin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

Research in to enzyme catalysis has enormously enriched the success of biological organic synthesis; particularly in the last decade, remarkable progress in biological catalysis has taken place leading to the application of enzymes to a wider extent in industrial processes. The benefits of establishing enzymes as industrial catalysts are founded on the need to develop a 'clean' and 'pure' technology which carry out isomer and region selective reactions; generate or transform pure isomers compared with racemic mixtures and produce pure compounds in comparison with mixtures of by-products often arising from conventional chemical synthesis. With the onset of molecular biology and genetics, the manufacturing of high value proteins in recombinant host cells has become commonplace; nevertheless, there needs to be a better understanding of the optimum conditions for the production of every recombinant protein. In this study, the over expression of an industrially important amine oxidase - D-Amino Acid Oxidase (DAAO) - was attempted using two different expression systems: Escherichia coli and Pichia pastoris in order to establish the optimum conditions for industrial production. Amine oxidases exhibit stereoselectivity; ergo they can theoretically be used for the deracemisation of nonopticallypure mixtures of amines leading to optically pure amines of high value.Furthermore, DAAO is involved in the production of 7-aminocephalosporanic acid (7-ACA) from cephalosporin c (CPC), which can be used in the synthesis of novel cephalosporin antibiotic derivatives. In order to accelerate development of these new antibiotics DAAO must be readily available. Overexpression of DAAO in E. coli was studied under varying experimental conditions in order to ascertain the best conditions for enzymatic activity whilst simultaneously investigating the variations between both defined and complex media to understand suitability for scale-up.Although E. coli is still regarded as the 'go to' organisms for initial laboratory scale up the methylotrophic yeast P. pastoris is considered an industrial workhorse for the production of recombinant proteins and thus the expression of DAAO was also investigated to ascertain how enzyme activities are affected by this expression system. Furthermore, the supplementation of media with different nutrient sources of varying complexity was investigated, as was the implementation of co-feeding inorder to improve carbon flux during recombinant protein production. Finally, the oxygen availability was investigated in order to gain important understandings on its effects on microbial physiology and DAAO activity.

Novel Enzyme And Whole Cell Biocatalysts

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Author : Anwar Sunna
language : en
Publisher: MDPI
Release Date : 2020-11-04

Novel Enzyme And Whole Cell Biocatalysts written by Anwar Sunna and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-04 with Science categories.

The concept of a circular economy relies on waste reduction, valorization, and recycling. Global trends for “green” synthesis of chemicals have positioned the field of enzyme technology and biocatalysis (multi-enzymes and whole-cells) as an alternative for the synthesis of more social- and environmentally-responsible bio-based chemicals. Recent advances in synthetic biology, computational tools, and metabolic engineering have supported the discovery of new enzymes and the rational design of whole-cell biocatalysts. In this book, we highlight these current advances in the field of biocatalysis, with special emphasis on novel enzymes and whole-cell biocatalysts for applications in several industrial biotechnological applications.

Discovery And Properties Of Enzymes For Biocatalytic Production Of Beta Amino Acids

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Author : Rijksuniversiteit Groningen
language : en
Publisher:
Release Date : 2014

Discovery And Properties Of Enzymes For Biocatalytic Production Of Beta Amino Acids written by Rijksuniversiteit Groningen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

Towards Industrial Production Of A Useful Biocatalyst For Amino Acid Synthesis

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Author : Oluwasola Okor
language : en
Publisher:
Release Date : 2005

Towards Industrial Production Of A Useful Biocatalyst For Amino Acid Synthesis written by Oluwasola Okor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Amino acids categories.

Synthetic Production And Utilization Of Amino Acids

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Author : Takeo Kaneko
language : en
Publisher: Halsted Press
Release Date : 1974

Synthetic Production And Utilization Of Amino Acids written by Takeo Kaneko and has been published by Halsted Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Science categories.

Toward The Development Of A Biocatalytic Process For The Production Of Beta Aryl Beta Amino Acids

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Author : Nishanka Dilini Ratnayake
language : en
Publisher:
Release Date : 2015

Toward The Development Of A Biocatalytic Process For The Production Of Beta Aryl Beta Amino Acids written by Nishanka Dilini Ratnayake and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Electronic dissertations categories.