Biochemical Studies On Enzymatic Domains From Trans Acyltransferase Polyketide Synthases By Mass Spectrometry
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Biochemical Studies On Enzymatic Domains From Trans Acyltransferase Polyketide Synthases By Mass Spectrometry
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Author : Matthew Jenner
language : en
Publisher:
Release Date : 2015
Biochemical Studies On Enzymatic Domains From Trans Acyltransferase Polyketide Synthases By Mass Spectrometry written by Matthew Jenner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Polyketides categories.
Using Mass Spectrometry For Biochemical Studies On Enzymatic Domains From Polyketide Synthases
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Author : Matthew Jenner
language : en
Publisher: Springer
Release Date : 2016-04-27
Using Mass Spectrometry For Biochemical Studies On Enzymatic Domains From Polyketide Synthases written by Matthew Jenner and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-27 with Science categories.
This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully studied with regard to the initial acylation step of KS-catalysis. In addition, the ability to alter the substrate tolerance of KS domains by simple point mutations in the active site has been demonstrated. A series of acyl-ACPs have been synthesised using a novel methodology and employed to probe the substrate specificity of both KS domains and the previously uncharcterised acyl hydrolase domain, PedC. KS-catalysed chain elongation reactions have also been conducted and monitored by ESI-MS/MS. All KS domains studied exhibited higher substrate specificity at the elongation step than in the preceeding acylation step. Furthermore, a mechanism of reversible acylation is proposed using the PsyA ACP1-KS1 di-domain. The findings in this thesis provide important insights into mechanisms of KS specificity and show that mutagenesis can be used to expand the repertoire of acceptable substrates for future PKS engineering.
Natural Product Biosynthesis
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Author : Christopher T. Walsh
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-04-28
Natural Product Biosynthesis written by Christopher T. Walsh and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-28 with Science categories.
Authored by leading experts in the enzymology of natural product biosynthesis, this textbook provides a thorough description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500-600,000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, to pharmacognocists and chemical ecologists, to bioengineers and synthetic biologists.
Comprehensive Natural Products Iii
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Author :
language : en
Publisher: Elsevier
Release Date : 2020-07-22
Comprehensive Natural Products Iii written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with Science categories.
Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1999
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medicine categories.
The Science Of Flavonoids
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Author : Erich Grotewold
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-07
The Science Of Flavonoids written by Erich Grotewold and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-07 with Science categories.
This is the only book of its kind to provide an overview of the science of flavonoids in plants.
The Polyketide Metabolites
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Author : David O'Hagan
language : en
Publisher: Ellis Horwood
Release Date : 1991
The Polyketide Metabolites written by David O'Hagan and has been published by Ellis Horwood this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Comprehensive Natural Products Chemistry
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Author : Derek Barton
language : en
Publisher: Newnes
Release Date : 1999-02-18
Comprehensive Natural Products Chemistry written by Derek Barton and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-02-18 with Science categories.
Comprehensive Natural Products Chemistry
Metabolic Engineering
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Author : Jens Nielsen
language : en
Publisher: Springer
Release Date : 2003-07-03
Metabolic Engineering written by Jens Nielsen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-03 with Science categories.
Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.
Plant Derived Natural Products
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Author : Anne E. Osbourn
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-07-07
Plant Derived Natural Products written by Anne E. Osbourn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-07 with Science categories.
Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.