Bioinformatics Analysis Of Alternative Splicing Using Splicing Graphs
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Bioinformatics Analysis Of Alternative Splicing Using Splicing Graphs
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Author : Durgaprasad Bollina
language : en
Publisher:
Release Date : 2008
Bioinformatics Analysis Of Alternative Splicing Using Splicing Graphs written by Durgaprasad Bollina and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Bioinformatics categories.
Alternative Splicing In The Postgenomic Era
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Author : Benjamin J. Blencowe
language : en
Publisher: Springer
Release Date : 2010-11-29
Alternative Splicing In The Postgenomic Era written by Benjamin J. Blencowe and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-29 with Medical categories.
Yet again Springer has reached the market before everyone. This is the first book that is solely dedicated to the topic of alternative splicing. The book contains chapters by experts in the field that cover nearly all aspects of this hugely important subject. The purpose of the text is to provide a single, authoritative source of information on alternative splicing that is accessible to researchers in diverse fields. It is suitable for beginners and experts alike.
Alternative Splicing
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Author : Peter Scheiffele
language : en
Publisher: Springer Nature
Release Date : 2022-07-27
Alternative Splicing written by Peter Scheiffele and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.
This detailed volume collects commonly used and cutting-edge methods to analyze alternative splicing, a key step in gene regulation. After an introduction of the alternative splicing mechanism and its targeting for therapeutic strategies, the book continues with techniques for analyzing alternative splicing profiles in complex biological systems, visualizing and localizing alternative spliced transcripts with cellular and sub-cellular resolution, probing regulators of alternative splicing, as well as assessing the functional consequences of alternative splicing. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Alternative Splicing: Methods and Protocols serves as an ideal guide for both RNA aficionados that want to implement novel approaches in their labs and novices undertaking alternative splicing projects.
Computational Methods For Next Generation Sequencing Data Analysis
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Author : Ion Mandoiu
language : en
Publisher: John Wiley & Sons
Release Date : 2016-10-03
Computational Methods For Next Generation Sequencing Data Analysis written by Ion Mandoiu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-03 with Computers categories.
Introduces readers to core algorithmic techniques for next-generation sequencing (NGS) data analysis and discusses a wide range of computational techniques and applications This book provides an in-depth survey of some of the recent developments in NGS and discusses mathematical and computational challenges in various application areas of NGS technologies. The 18 chapters featured in this book have been authored by bioinformatics experts and represent the latest work in leading labs actively contributing to the fast-growing field of NGS. The book is divided into four parts: Part I focuses on computing and experimental infrastructure for NGS analysis, including chapters on cloud computing, modular pipelines for metabolic pathway reconstruction, pooling strategies for massive viral sequencing, and high-fidelity sequencing protocols. Part II concentrates on analysis of DNA sequencing data, covering the classic scaffolding problem, detection of genomic variants, including insertions and deletions, and analysis of DNA methylation sequencing data. Part III is devoted to analysis of RNA-seq data. This part discusses algorithms and compares software tools for transcriptome assembly along with methods for detection of alternative splicing and tools for transcriptome quantification and differential expression analysis. Part IV explores computational tools for NGS applications in microbiomics, including a discussion on error correction of NGS reads from viral populations, methods for viral quasispecies reconstruction, and a survey of state-of-the-art methods and future trends in microbiome analysis. Computational Methods for Next Generation Sequencing Data Analysis: Reviews computational techniques such as new combinatorial optimization methods, data structures, high performance computing, machine learning, and inference algorithms Discusses the mathematical and computational challenges in NGS technologies Covers NGS error correction, de novo genome transcriptome assembly, variant detection from NGS reads, and more This text is a reference for biomedical professionals interested in expanding their knowledge of computational techniques for NGS data analysis. The book is also useful for graduate and post-graduate students in bioinformatics.
Bioinformatics Analysis Of Alternative Splicing In Fungi
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Author : Patricia Sieber
language : en
Publisher:
Release Date : 2019*
Bioinformatics Analysis Of Alternative Splicing In Fungi written by Patricia Sieber and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019* with categories.
Alternative Splicing And Disease
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Author : Philippe Jeanteur
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-10-04
Alternative Splicing And Disease written by Philippe Jeanteur and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-04 with Science categories.
Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.
Regulation Of Alternative Splicing
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Author : Philippe Jeanteur
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-10-21
Regulation Of Alternative Splicing written by Philippe Jeanteur and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-10-21 with Science categories.
The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.
Bioinformatics Analysis Of Alternative Splicing In Chlamydomonas Reinhardtii
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Author : Praveen Kumar Raj Kumar
language : en
Publisher:
Release Date : 2010
Bioinformatics Analysis Of Alternative Splicing In Chlamydomonas Reinhardtii written by Praveen Kumar Raj Kumar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Bioinformatics categories.
Pre-mRNA splicing is one of the fundamental post-transcriptional processes in eukaryotic gene expression and regulation. Alternative Splicing (AS) occurs when different splice sites of pre-mRNA are processed to generate mRNA isoforms leading to diverse proteins with functional and/or structural differences from the same gene. The first chapter of my thesis gives a mini review on alternative splicing in plants. The second chapter reports the finding on the bioinformatics analysis of alternative splicing in Chlamydomonas reinhardtii. Unlike in mammals, intron retention is the major mode of alternative splicing in plants, suggesting distinctive regulatory mechanisms of AS between plants and animals. Chlamydomonas reinhardtii, an alga that shares both animal and plant traits serves a good model to study evolutionary perspective of AS and its underlying mechanisms. In this alga, retained introns are significantly shorter and have weaker splice sites, with fewer G-triplets intronic splicing enhancers and C-triplets than constitutively spliced introns.
A Genomic View Of Alternative Splicing
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Author : Yi Xing
language : en
Publisher:
Release Date : 2006
A Genomic View Of Alternative Splicing written by Yi Xing and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Algorithms In Bioinformatics
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Author : Inge Jonassen
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-09-07
Algorithms In Bioinformatics written by Inge Jonassen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-07 with Science categories.
This book constitutes the refereed proceedings of the 4th International Workshop on Algorithms in Bioinformatics, WABI 2004, held in Bergen, Norway, in September 2004. The 39 revised full papers presented were carefully reviewed and selected from 117 submissions. Among the topics addressed are all current issues of algorithms in bioinformatics, such as exact and approximate algorithms for genomics, genetics, sequence analysis, gene and signal recognition, alignment, molecular evolution, phylogenetics, structure determination or prediction, gene expression and gene networks, proteomics, functional genomics, and drug design.