Bioinformatics For Immunomics
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Bioinformatics For Immunomics
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Author : Darren D.R. Flower
language : en
Publisher: Springer
Release Date : 2009-10-03
Bioinformatics For Immunomics written by Darren D.R. Flower and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-03 with Medical categories.
Like many words, the term “immunomics” equates to different ideas contingent on context. For a brief span, immunomics meant the study of the Immunome, of which there were, in turn, several different definitions. A now largely defunct meaning rendered the Immunome as the set of antigenic peptides or immunogenic proteins within a single microorganism – be that virus, bacteria, fungus, or parasite – or microbial population, or antigenic or allergenic proteins and peptides derived from the environment as a whole, containing also proteins from eukaryotic sources. However, times have changed and the meaning of immunomics has also changed. Other newer definitions of the Immunome have come to focus on the plethora of immunological receptors and accessory molecules that comprise the host immune arsenal. Today, Immunomics or immunogenomics is now most often used as a synonym for high-throughput genome-based immunology. This is the study of aspects of the immune system using high-throughput techniques within a conc- tual landscape borne of both clinical and biophysical thinking.
Bioinformatics For Immunomics
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Author : Darren D.R. Flower
language : en
Publisher: Springer
Release Date : 2009-11-05
Bioinformatics For Immunomics written by Darren D.R. Flower and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-05 with Medical categories.
Like many words, the term “immunomics” equates to different ideas contingent on context. For a brief span, immunomics meant the study of the Immunome, of which there were, in turn, several different definitions. A now largely defunct meaning rendered the Immunome as the set of antigenic peptides or immunogenic proteins within a single microorganism – be that virus, bacteria, fungus, or parasite – or microbial population, or antigenic or allergenic proteins and peptides derived from the environment as a whole, containing also proteins from eukaryotic sources. However, times have changed and the meaning of immunomics has also changed. Other newer definitions of the Immunome have come to focus on the plethora of immunological receptors and accessory molecules that comprise the host immune arsenal. Today, Immunomics or immunogenomics is now most often used as a synonym for high-throughput genome-based immunology. This is the study of aspects of the immune system using high-throughput techniques within a conc- tual landscape borne of both clinical and biophysical thinking.
Immunomic Discovery Of Adjuvants And Candidate Subunit Vaccines
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Author : Darren R. Flower
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-09
Immunomic Discovery Of Adjuvants And Candidate Subunit Vaccines written by Darren R. Flower and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-09 with Medical categories.
This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.
Immunoinformatics
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Author : Christian Schönbach
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-21
Immunoinformatics written by Christian Schönbach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-21 with Medical categories.
In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.
Clinical Applications Of Immunomics
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Author : Andras Falus
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-23
Clinical Applications Of Immunomics written by Andras Falus and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-23 with Medical categories.
Innate immunity is one the most evolutionally conserved systems, designed to protect the organism from viruses and bacterial infections, stress and many other types of attacks from the outside world. During the past decade, the capacity of molecular biology and information technology to produce and analyse data have grown exponentially, rapidly reforming many aspects of immunology research in the post-genomics era. As a result, scientific understanding of signalling networks governing the innate immunity response in human tissues and other organisms has evolved beyond recognition, compared to even just a decade ago. Many strategies have been designed over the years to identify novel proteins, which have a crucial role in innate immunity responses by regulating particular signalling pathways. These projects had many advantages, including the definition of novel drug targets, as exemplified by the recent success of anti-TNF therapy, as well as leading to a better, system-wide understanding of the molecular control of innate immunity. In the past few years, a new concept, Immunomics, has been adopted to define an emerging, multidisciplinary field of research (Schonbach, 2003). Although rapid progress has been made to identify the proteins playing pivotal roles in the innate immunity–related signalling pathways (for example, TIR signalling pathways), the catalogue of proteins with a key regulatory function identified and studied is far from completed. Novel proteins need to be char- terised to gain a more comprehensive picture of how signalling networks are regulated.
Microarray Bioinformatics
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Author : Dov Stekel
language : en
Publisher: Cambridge University Press
Release Date : 2003-09-08
Microarray Bioinformatics written by Dov Stekel and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-08 with Medical categories.
This book is a comprehensive guide to all of the mathematics, statistics and computing you will need to successfully operate DNA microarray experiments. It is written for researchers, clinicians, laboratory heads and managers, from both biology and bioinformatics backgrounds, who work with, or who intend to work with microarrays. The book covers all aspects of microarray bioinformatics, giving you the tools to design arrays and experiments, to analyze your data, and to share your results with your organisation or with the international community. There are chapters covering sequence databases, oligonucleotide design, experimental design, image processing, normalisation, identifying differentially expressed genes, clustering, classification and data standards. The book is based on the highly successful Microarray Bioinformatics course at Oxford University, and therefore is ideally suited for teaching the subject at postgraduate or professional level.
Integrated Omics Approaches To Infectious Diseases
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Author : Saif Hameed
language : en
Publisher: Springer Nature
Release Date : 2021-07-18
Integrated Omics Approaches To Infectious Diseases written by Saif Hameed and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-18 with Medical categories.
This book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.
Bio Inspired Models Of Network Information And Computing Systems
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Author : Junichi Suzuki
language : en
Publisher: Springer
Release Date : 2012-07-25
Bio Inspired Models Of Network Information And Computing Systems written by Junichi Suzuki and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-25 with Computers categories.
This book constitutes the thoroughly refereed post-conference proceedings of the 5th International ICST Conference on Bio-Inspired Models of Network, Information, and Computing Systems (BIONETICS 2010) which was held in Boston, USA, in December 2010. The 78 revised full papers were carefully reviewed and selected from numerous submissions for inclusion in the proceedings. BIONETICS 2010 aimed to provide the understanding of the fundamental principles and design strategies in biological systems and leverage those understandings to build bio-inspired systems.
Chemical Genomics And Proteomics Second Edition
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Author : Ferenc Darvas
language : en
Publisher: CRC Press
Release Date : 2013-01-11
Chemical Genomics And Proteomics Second Edition written by Ferenc Darvas and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-11 with Medical categories.
Since the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics. This second edition has been updated to uniquely reflect this interdisciplinary feature as well as the remarkable developments that have occurred. The new edition also covers innovative applications from cell biology to drug discovery to, more recently, clinical diagnostics and medical practice, which utilize the concepts of chemical genomics. The text provides an overview of the strategies and methodologies of chemical genomics, focusing on emerging technologies and recent applications in the areas of combination chemical genetics, toxicogenomics, drug chemical genomics and proteomics, and orthogonal chemical genetics. It describes the development and application of novel analytical methods used in lipodomics, such as steroidomics. The book also discusses biomarker discovery applications of microarray technologies using DNA, RNA, and protein and glycan arrays. Chapters cover further applications of biomolecular biomarkers for disease diagnosis, in small molecule drug R&D, and during therapeutic use of medicines. These include prognostic, disease specific, response (surrogate), and toxicity biomarkers. In addition, the text explores the principles of contemporary systems biology and genomics in experimental medicine—a new paradigm that demonstrates a network-oriented view and advanced statistical and informatics data management, opening the way toward personalized medicine. Finally, various in silico chemogenomics approaches are addressed for predicting binding of drug candidates to undesirable targets, which would help in designing better clinical candidates with fewer side effects. This new edition benefits a broad range of readers from industrial and academic researchers in drug discovery, medicinal chemistry, and molecular and cell biology to physicians in clinical diagnostics and students in related fields of study.
Computational Immunology
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Author : Josep Bassaganya-Riera
language : en
Publisher: Academic Press
Release Date : 2015-10-21
Computational Immunology written by Josep Bassaganya-Riera and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-21 with Medical categories.
Computational Immunology: Models and Tools encompasses the methodological framework and application of cutting-edge tools and techniques to study immunological processes at a systems level, along with the concept of multi-scale modeling. The book's emphasis is on selected cases studies and application of the most updated technologies in computational modeling, discussing topics such as computational modeling and its usage in immunological research, bioinformatics infrastructure, ODE based modeling, agent based modeling, and high performance computing, data analytics, and multiscale modeling. There are also modeling exercises using recent tools and models which lead the readers to a thorough comprehension and applicability. The book is a valuable resource for immunologists, computational biologists, bioinformaticians, biotechnologists, and computer scientists, as well as all those who wish to broaden their knowledge in systems modeling. - Offers case studies with different levels of complexity - Provides a detailed view on cutting-edge tools for modeling that are useful to experimentalists with limited computational skills - Explores the usage of simulation for hypothesis generation, helping the reader to understand the most valuable points on experimental setting