Biological Oxidations Microsomal Cytochrome P 450 And Other Hemoprotein Systems
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Biological Oxidations Microsomal Cytochrome P 450 And Other Hemoprotein Systems
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Author : Sidney Fleischer
language : en
Publisher:
Release Date : 1978
Biological Oxidations Microsomal Cytochrome P 450 And Other Hemoprotein Systems written by Sidney Fleischer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Blood proteins categories.
Biomembranes Part H Visual Pigments And Purple Membranes I
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Author :
language : en
Publisher: Academic Press
Release Date : 1982-05-12
Biomembranes Part H Visual Pigments And Purple Membranes I written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-05-12 with Science categories.
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Biomembranes
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Author : Sidney Fleischer
language : en
Publisher:
Release Date : 1984
Biomembranes written by Sidney Fleischer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with categories.
Biomembranes Part C Biological Oxidations Microsomal Cytochrome P 450 And Other Homoprotein Systems
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Author :
language : en
Publisher: Academic Press
Release Date : 1978-06-28
Biomembranes Part C Biological Oxidations Microsomal Cytochrome P 450 And Other Homoprotein Systems written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978-06-28 with Science categories.
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Cytochromes P450
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Author : Costas Ioannides
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008-06-27
Cytochromes P450 written by Costas Ioannides and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-27 with Science categories.
During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme systems worldwide the interest in cytochromes P450 very much reflects its importance in the elimination of drugs and other chemicals from the body and its role in chemical toxicity and in the aetiology of diseases such as cancer. There has been significant progress in research in this area in recent years and current books on this subject are now out of date. This much needed, new, fully up-to-date publication fills this gap and emphasises the new relevant topics that have emerged during the last decade in an easily accessible manner. The enzyme system, cytochromes P450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book. Part A of this monograph introduces the reader to the current knowledge of the evolutionary development of cytochrome P450 structure and function. Furthermore, it deals with the role of this enzyme in the formation of reactive intermediates. The shrewd and extensive utilisation of the molecular biology methodology very rapidly led to a vast body of enzymes calling for a classification of the plethora of different cytochromes P450 (the superfamily) into families and subfamilies. This is aptly exemplified by the ten chapters in Part B of this book, dealing with ten subfamilies and two families of cytochrome P450. Part C offers an insight into another aspect of cytochrome P450 research, namely its regulation through receptor-mediated stimuli - as opposed to enzyme induction or inhibition. The final chapter translates the current data on one of several drug metabolising systems into clinical application and highlights the role of cytochromes P450 in the treatment of neoplastic growth. The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics. Essential and invaluable information is provided for the industrial research scientist working with fine chemicals, and especially those in the pharmaceutical industry, dealing with the safety evaluation of chemicals or being involved in the study of their metabolism, pharmacokinetics and toxicological properties. It should also prove of interest to Regulators concerned with the safety evaluation of chemicals, research pharmacologists and toxicologists, and postgraduate students studying drug metabolism and toxicology at an advanced level.
Molecular Mechanisms Of Oxygen Activation
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Author : Osamu Hayaishi
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Molecular Mechanisms Of Oxygen Activation written by Osamu Hayaishi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Molecular Mechanisms of Oxygen Activation reviews some of the major advances that have been made in our understanding of the molecular mechanisms underlying oxygen activation, with emphasis on the role of oxygen activation in contemporary biological processes. The biological role of oxygenases in the metabolism of fatty acids and steroids is discussed, along with the functions of heme-containing dioxygenases, a-ketoglutarate-coupled dioxygenases, and pterin-requiring aromatic amino acid hydroxylases. This book is comprised of 14 chapters and begins with an overview of the general properties and biological functions of oxygenases, along with the chemical aspects of oxygen fixation reactions. The reader is then introduced to research concerning fatty acid and steroid oxygenases which has appeared in the literature since 1962, paying particular attention to the mechanism of oxygenation and the biosynthesis and metabolism of steroids. Subsequent chapters explore the biological functions of a variety of oxygenases such as heme-containing dioxygenases, copper-containing oxygenases, flavoprotein oxygenases, and pterin-requiring aromatic amino acid hydroxylases. Superoxide dismutase, cytochrome c oxidase, peroxidase, and bacterial monoxygenases are also considered. This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry.
Biological Oxidation Systems V1
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Author : C.C. Reddy
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Biological Oxidation Systems V1 written by C.C. Reddy and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Biological Oxidation Systems, Volume I is a collection of papers presented at the 1989 Bangalore Symposium on Oxygen Systems. This symposium covers various research studies on the essential roles, and the dangers of dioxygen reactions in biology. This volume is organized into five parts encompassing 32 chapters, and starts with an overview of the biological oxidation mechanisms involving oxygen and reduced oxygen derivatives. Parts I and II deal with the catalytic role of cytochrome P-450 and oxidase and oxygenase containing a flavin or pteridine enzymes in several biological oxidation reactions. These parts examine the biochemical aspects, reaction kinetics, and reaction mechanisms of such reactions. Parts III and IV describe first the structure function and properties of copper-containing oxidases and oxygenases. These parts also discuss the role of nonheme iron-containing and other oxygenases in the indole metabolism. Part V focuses on the role of peroxidase enzymes in cell protection and metabolism. This book will prove useful to biologists, enzyme scientists, and researchers.
Microsomes And Drug Oxidations
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Author : Volker Ullrich
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Microsomes And Drug Oxidations written by Volker Ullrich and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Microsomes and Drug Oxidations is a record of the proceedings of the Third International Symposium on Microsomes and Drug Oxidations, held in Berlin, Germany in July 1976. The compendium provides an overview of knowledge on the oxidative metabolism of drugs, carcinogens, and various other environmental chemicals. Topics discussed include lipid structure of liver microsomal membranes; interactions between cytochrome p-450 and nadphcytochrome p-450 reductase in the microsomal membrane; impact of drug monoxygenases in clinical pharmacology; and the manner in which oxygen participates in mixed-function oxidation reactions. Pharmacologists, toxicologists, biochemists, and researchers in the pharmaceutical industry will find the book highly insightful.
Cytochrome P450 Protocols
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Author : Ian R. Phillips
language : en
Publisher: Humana Press
Release Date : 2013-03-09
Cytochrome P450 Protocols written by Ian R. Phillips and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
Cytochromes P450 (CYPs) comprise a large superfamily of proteins that are of central importance in the detoxification or activation of a tremendous number of natural and synthetic hydrophobic xenobiotics, including many therapeutic drugs, chemical carcinogens and environmental pollutants. CYPs are important in mediating interactions between an organism and its chemical environment and in the regulation of physiological processes. Cytochrome P450 Protocols, Third Edition focuses on high-throughput methods for the simultaneous analysis of multiple CYPs, substrates or ligands. Although the emphasis is on CYPs of mammalian origin, it reflects an increasing interest in CYPs of bacterial species. Also included are chapters on cytochrome P450 reductase (the redox partner of CYPs) and the flavin-containing monooxygenases (FMOs), and metabolomic and lipidomic approaches for identification of endogenous substrates of CYPs (‘de-orphanizing’ CYP substrates). Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cytochrome P450 Protocols, Third Edition provides a wide range of techniques accessible to researchers in fields as diverse as biochemistry, molecular biology, pharmacology, toxicology, environmental biology and genetics.
Cytochrome P450
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Author : Paul R. Ortiz de Montellano
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-05
Cytochrome P450 written by Paul R. Ortiz de Montellano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-05 with Medical categories.
Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.