Biology Of Chlamydia
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Biology Of Chlamydia
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Author : Georg Häcker
language : en
Publisher: Springer
Release Date : 2018-06-25
Biology Of Chlamydia written by Georg Häcker and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-25 with Medical categories.
The genus Chlamydia encompasses a number of species of obligate intracellular bacteria, including important human pathogens like the most common bacterial agent of sexually transmitted disease. This volume reviews current knowledge of chlamydial biology, covering the unusual structure of the bacteria – which alternate between metabolically almost inactive and fast-dividing forms. It also discusses the ways in which Chlamydia manipulates the host cytoskeleton and subverts the host cell’s defence, and illustrates how genomics have begun to uncover the diversity and complexity of chlamydial strains that look very similar but may cause distinct forms of disease. Further, it describes how techniques are now finally being established that can genetically modify Chlamydia, and discusses why such modification is still very difficult and what progress we can expect. Lastly, it presents our current understanding of chlamydial disease: what do we know about chronic infections, what are the mechanisms of inflammatory damage, and what are the prospects of a vaccine? Written be specialists in these various areas, the book is a valuable work of reference for students and scientists with an interest in the molecular, cellular and immunobiology of these fascinating bacteria.
The Role Of Viable But Non Infectious Developmental Forms In Chlamydial Biology
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Author : Robert V Schoborg
language : en
Publisher: Frontiers E-books
Release Date : 2014-11-04
The Role Of Viable But Non Infectious Developmental Forms In Chlamydial Biology written by Robert V Schoborg and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-04 with Infectious and parasitic diseases categories.
The chlamydiae are Gram-negative, obligate intracellular bacteria with a complex developmental cycle comprising a metabolically less-active, infectious stage, the elementary body (EB), and a metabolically more active stage, the reticulate body (RB). They are responsible for many acute and chronic diseases in humans and animals. In order to play a causative role in chronic diseases, chlamydiae would need to persist and to re-activate within infected cells/tissues for extended periods of time. Persistence in vitro is defined as viable but non-cultivable chlamydiae involving morphologically enlarged, aberrant, and nondividing RBs, termed aberrant bodies (AB). In vitro, alterations of the normal developmental cycle of chlamydiae can be induced by the addition of Interferon-? (IFN-?), tumor necrosis factor-a (TNF-a) and penicillin G exposure as well as amino acid or iron deprivation, monocyte infection and co-infection with viruses. In vivo, key questions include whether or not ABs occur in infected patients and animals and whether such ABs can contribute to prolonged, chronic inflammation, fibrosis, and scarring through continuing stimulation of the host immune system known from diseases such as trachoma, pelvic inflammatory disease, reactive arthritis and atherosclerosis. To date, the direct causal role in the pathogenesis of chlamydial infection and persistence in vivo has been questioned since there was no tractable animal model of chlamydial persistence so far. A very recent study was able to establish an experimental animal model of in vivo persistence, when C. muridarum vaginally-infected mice were gavaged with amoxicillin. Amoxicillin treatment induced C. muridarum to enter the persistent state in vivo. Recent in vivo data from patients indicate that viable but non-infectious developmental stages are present in the genital tract of chronically-infected women and that the gastrointestinal tract might be a reservoir for persistent chlamydial infections at other sites.
Chlamydiae And Chlamydial Infections
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Author : Svetoslav P. Martinov
language : en
Publisher: CRC Press
Release Date : 2022-09-01
Chlamydiae And Chlamydial Infections written by Svetoslav P. Martinov and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-01 with Science categories.
Chlamydiae are a group of obligate intracellular microorganisms with a homogeneous group-specific antigenic structure, and a unique mode of development. The infections caused by them are unprecedented and wide-spread throughout the world, including a broad range of hosts among domestic and animal species and humans, and a variety of clinical manifestations. The uniqueness of chlamydia pathology consists mainly in the fact that the agents of the individual diseases are so close in their biological properties that they are represented only by the single genus Chlamydia, which includes all currently recognized species.Although chlamydiae and chlamydial infections were discovered a long time ago, they are still under-researched and relatively unknown to broad circles of microbiologists, virologists, epidemiologists and clinicians. A number of issues relating to molecular biology, pathogenesis, mechanisms of Chlamydia development and their interactions with cells, as well as their genetic conditioning and regulation, remain unclear. The same is true for ambiguities, problems and contradictions related to epidemiology, diagnostic approaches, immunity and vaccines. Based on scientific facts and the analysis of literature, and the experience of the author, Chlamydiae and Chlamydial Infections attempts to shed light on the cited problems, in terms of modern microbiology, cell biology and molecular biology. The scientific topics discussed include:• Biological, morphological and antigenic properties of Chlamydia spp• Genes, genomic structure and genetic regulations• Conventional diagnostic methods and examinations• Detection and differentiation of Chlamydia organisms by DNA detection systems• Clinical forms and manifestations and drug therapy• Pathology• Epidemiological peculiarities of Chlamydia ─ induced diseases in animals and humans• Immunity and vaccines
Intracellular Pathogens I
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Author : Ming Tan
language : en
Publisher: American Society for Microbiology Press
Release Date : 2012-09-15
Intracellular Pathogens I written by Ming Tan and has been published by American Society for Microbiology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-15 with Science categories.
A current review of basic research on Chlamydiales biology and pathogenesis in one comprehensive volume. • Details the scientific knowledge about how these obligate intracellular bacteria invade, survive and replicate inside eukaryotic cells. • Describes the spectrum of disease caused by an infection including protective and pathologic immune responses. • Describes the latest developments, including genomics and biomathematical modeling, and progress towards genetic tools and a vaccine. • Serves as a significant research book for scientists, physicians, medical students, public health professionals, epidemiologists, biocomputational scientists and government policy makers.
Chlamydia
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Author : Richard Scott Stephens
language : en
Publisher:
Release Date : 1999
Chlamydia written by Richard Scott Stephens and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Chlamydia categories.
Chlamydia Biology
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Author : Ming Tan
language : en
Publisher: Caister Academic Press Limited
Release Date : 2020-02
Chlamydia Biology written by Ming Tan and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02 with Medical categories.
Containing nineteen chapters this comprehensive book is essential reading for every Chlamydia researcher.
Chlamydia Trachomatis
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Author : Amanda Claire Brown
language : en
Publisher:
Release Date : 2019
Chlamydia Trachomatis written by Amanda Claire Brown and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Bacteriology categories.
This book explores cutting-edge methods to work with the notoriously difficult, but highly prevalent, obligate intracellular pathogen, Chlamydia trachomatis. These include techniques to identify Chlamydia trachomatis in patient samples, ranging from simple point-of-care tests to whole genome sequencing; methods for propagation of strains in both cell culture and animal models; techniques to manipulate Chlamydia trachomatis in molecular genetic methodologies; a high-throughput screening method for testing new potential drugs against intracellular bacteria; a screen for antibiotic resistance; methods for labeling and enumeration; and descriptions of genotyping technologies, as well as dual RNA-Seq transcriptional profiling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative, practical, and relevant, Chlamydia trachomatis: Methods and Protocols serves as an ideal reference for scientists searching for a better understanding of the pathogen, allowing for the development of improved treatment regimens and the discovery of new drugs.
Advances In Chlamydiaceae Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Advances In Chlamydiaceae Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Medical categories.
Advances in Chlamydiaceae Research and Application / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Chlamydiaceae in a concise format. The editors have built Advances in Chlamydiaceae Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chlamydiaceae in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Chlamydiaceae Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Chlamydiaceae Infections Advances In Research And Treatment 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Chlamydiaceae Infections Advances In Research And Treatment 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Medical categories.
Chlamydiaceae Infections—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Chlamydiaceae Infections in a concise format. The editors have built Chlamydiaceae Infections—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chlamydiaceae Infections in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chlamydiaceae Infections—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Chlamydial Infection A Clinical And Public Health Perspective
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Author : C.M. Black
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2013-06-19
Chlamydial Infection A Clinical And Public Health Perspective written by C.M. Black and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-19 with Medical categories.
Chlamydiae are obligate intracellular bacteria that cause one of the most common sexually transmitted infectious diseases in the world. The infection disproportionately impacts women and the highest prevalence of infection is found in adolescents. Most chlamydial infections are asymptomatic. Untreated infections are sources of further spread of infection and can lead to serious consequences including pelvic inflammatory disease, infertility and chronic pelvic pain. Chlamydial infections also increase a person’s susceptibility to HIV and other STDs.Featuring contributions by internationally recognized experts in epidemiology, infectious disease research and chlamydial biology, this book provides up-to-date reviews from a clinical and public health perspective on chlamydia epidemiology and control programs, genomics and pathogenicity, diagnosis, treatment, host immune responses, and the latest on the search for an effective vaccine. Also included are chapters on the impact of chlamydial infection on specific populations such as the lesbian, gay, bisexual and transgender community, and an update on the outbreak in Europe of the invasive chlamydial infection, lymphogranuloma venereum or LGV. This comprehensive publication is intended for clinicians, public health workers and scientists with interest in sexually transmitted diseases, medical microbiology, infectious diseases and clinical research.