Biomaterials For Delivery And Targeting Of Proteins And Nucleic Acids
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Biomaterials For Delivery And Targeting Of Proteins And Nucleic Acids
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Author : Ram I. Mahato
language : en
Publisher: CRC Press
Release Date : 2004-12-28
Biomaterials For Delivery And Targeting Of Proteins And Nucleic Acids written by Ram I. Mahato and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-28 with Medical categories.
Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases. Introducing the principles of polymer science and chemistry, this book delineates the basic biology required for understanding how biomaterials can be used as drug-deliver vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Leading experts from around the world discuss the physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The book includes coverage biological barriers to extravasation and cellular uptake of proteins and nucleic acids.
Intracellular Delivery
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Author : Aleš Prokop
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-26
Intracellular Delivery written by Aleš Prokop and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-26 with Science categories.
This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.
Biomaterials For Delivery And Targeting Of Proteins And Nucleic Acids
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Author : Ram I. Mahato
language : en
Publisher: CRC Press
Release Date : 2004-12-28
Biomaterials For Delivery And Targeting Of Proteins And Nucleic Acids written by Ram I. Mahato and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-28 with Medical categories.
Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and che
Delivery Technologies For Biopharmaceuticals
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Author : Lene Jorgensen
language : en
Publisher: John Wiley & Sons
Release Date : 2009-10-23
Delivery Technologies For Biopharmaceuticals written by Lene Jorgensen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-23 with Science categories.
Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.
Drug Delivery Nanosystems
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Author : Natassa Pippa
language : en
Publisher: CRC Press
Release Date : 2019-01-15
Drug Delivery Nanosystems written by Natassa Pippa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-15 with Medical categories.
Nanotechnology seeks to exploit distinct technological advances controlling the structure of nanoscale biomaterials at a nanodimensional scale approaching individual molecules and their aggregates or supramolecular structures. The term "nanomedicine" is used to describe those technologies under the umbrella of nanotechnology that have therapeutic applications in human health. This book presents recent trends and research achievements in the field of pharmaceutical nanotechnology and advanced drug delivery nanosystems, especially for theranostic purposes. The applications of drug delivery nanosystems considered carriers of active pharmaceutical ingredients (APIs) (e.g., proteins, peptides, and nucleic acids) are analyzed on the basis of technology, preparation protocols, and biomedical applications. The book also extensively reports on the principles, design protocols, and applications of nanosystems in drug delivery, imaging, and targeting of active molecules of pharmaceutical interest.
Nucleic Acid Based Nanomaterials
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Author : Yunfeng Lin
language : en
Publisher: John Wiley & Sons
Release Date : 2024-04-24
Nucleic Acid Based Nanomaterials written by Yunfeng Lin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-24 with Science categories.
Nucleic Acid-Based Nanomaterials Learn about the cutting-edge nanotechnologies that play an important role in clinical and medical therapies Nucleic acids, the biomolecules that carry most of nature’s critical genetic information, are an omnipresent component of life on earth. Nanomaterials incorporating or otherwise built around nucleic acids and their key properties have a number of clinical and medical applications, including drug delivery and more. Biomaterials scientists and other professionals in these fields can benefit enormously from increased knowledge of these invaluable materials. Nucleic Acid-Based Nanomaterials supplies a thorough, rigorous overview of these materials and their possible applications. Beginning with an introduction to the history of nanomaterials and their nucleic acid-based subcategories, the book offers a detailed and state-of-the-art survey of the current research into these molecules, efforts to increase their biostability, and their incorporation into a range of industries. The result is an essential contribution to materials science in a variety of life-saving contexts. Nucleic Acid-Based Nanomaterials readers will also find: Application-oriented structure that grounds general concepts in their specific instantiations Detailed discussion of applications including drug delivery, tissue engineering, antimicrobial therapy, and more A rigorous yet accessible approach suitable for both academia and industry Nucleic Acid-Based Nanomaterials is ideal for chemists of all types, particularly biochemists and medical chemists, and those in industry.
Nanotechnology For The Delivery Of Therapeutic Nucleic Acids
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Author : Dan Peer
language : en
Publisher: CRC Press
Release Date : 2013-03-27
Nanotechnology For The Delivery Of Therapeutic Nucleic Acids written by Dan Peer and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-27 with Medical categories.
Nucleic acid (NA) therapeutics has been extensively studied both in the academia and in the pharmaceutical industry and is still considered the promise for new therapeutic modalities, especially in personalized medicine. The only hurdle that limits the translation of NA therapeutics from an academic idea to the new therapeutic modality is the lack
Spherical Nucleic Acids
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Author : Chad A. Mirkin
language : en
Publisher: CRC Press
Release Date : 2020-09-01
Spherical Nucleic Acids written by Chad A. Mirkin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-01 with Medical categories.
Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of Dr. Mirkin’s research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation. It is a reprint volume that compiles 101 key papers from high-impact journals in this research area published by the Mirkin Group at Northwestern University, Illinois, USA, within the International Institute for Nanotechnology, and collaborators. Volume 1 provides an overview and a historical framework of engineering matter from DNA-modified constructs and discusses the enabling features of nucleic acid–functionalized nanomaterials. Volume 2 covers design rules for colloidal crystallization, building blocks for crystal engineering, and DNA and RNA as programmable bonds. Volume 3 discusses colloidal crystallization processes and routes to hierarchical assembly, dynamic nanoparticle superlattices, surface-based and template-confined colloidal crystallization, optics and plasmonics with nanoparticle superlattices, and postsynthetic modification and catalysis with nanoparticle superlattices. Volume 4 covers diagnostic modalities, and intracellular therapeutic and diagnostic schemes based upon nucleic acid–functionalized nanomaterials.
Functional Polysaccharides For Biomedical Applications
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Author : Sabyasachi Maiti
language : en
Publisher: Woodhead Publishing
Release Date : 2019-06-11
Functional Polysaccharides For Biomedical Applications written by Sabyasachi Maiti and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-11 with Medical categories.
Functional Polysaccharides for Biomedical Applications examines the fundamentals and properties of these natural materials and their potential biomedical applications. With an emphasis on therapeutic and sensing applications, the book also reviews how polysaccharides can be modified for tissue engineering applications. Sections discuss the basics of polysaccharides, give an overview of the potential applications, look at novel materials and technologies for use in tissue regeneration and therapeutics, and detail current biomedical applications. With a strong focus on materials, engineering and applications, this book is a valuable resource for those with an interest in harnessing the biomedical potential of natural polymers. Describes strategies for developing polysaccharides-based biomedical devices Illustrates concepts and encompasses scope for clinical development Provides advanced and comprehensive information on biomedical constructs
Transforming Growth Factor Beta In Cancer Therapy Volume Ii
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Author : Sonia B. Jakowlew
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-01-01
Transforming Growth Factor Beta In Cancer Therapy Volume Ii written by Sonia B. Jakowlew and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-01 with Medical categories.
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.