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Bioresponsive Polymers

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Bioresponsive Polymers

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Author : Deepa H. Patel
language : en
Publisher: CRC Press
Release Date : 2020-10-08

Bioresponsive Polymers written by Deepa H. Patel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Science categories.

This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.

Bioresponsive Polymers

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Author : Deepa H Patel
language : en
Publisher: Apple Academic Press
Release Date : 2022-06

Bioresponsive Polymers written by Deepa H Patel and has been published by Apple Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06 with categories.

Biomimetic Bioresponsive And Bioactive Materials

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Author : Matteo Santin
language : en
Publisher: John Wiley & Sons
Release Date : 2012-04-10

Biomimetic Bioresponsive And Bioactive Materials written by Matteo Santin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-10 with Science categories.

The accessible introduction to biomaterials and their applications in tissue replacement, medical devices, and more Molecular and cell biology is being increasingly integrated into the search for high-performance biomaterials and biomedical devices, transforming a formerly engineering- and materials science–based field into a truly interdisciplinary area of investigation. Biomimetic, Bioresponsive, and Bioactive Materials presents a comprehensive introduction to biomaterials, discussing how they are selected, designed, and modified for integration with living tissue and how they can be utilized in the development of medical devices, orthopedics, and other related areas. Examining the physico chemical properties of widely used biomaterials and their uses in different clinical fields, the book explores applications including soft and hard tissue replacement; biointeractive metals, polymers, and ceramics; and in vitro, in vivo, and ex vivo biocompatibility tests and clinical trials. The book critically assesses the clinical level of research in the field, not only presenting proven research, but also positing new avenues of exploration. Biomimetic, Bioresponsive, and Bioactive Materials contains everything needed to get a firm grasp on materials science, fast. Written in an accessible style and including practice questions that test comprehension of the material covered in each chapter, the book is an invaluable tool for students as well as professionals new to the field.

Investigations Of Bioresponsive Polymers In Triple Negative Breast Cancers

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Author : Patricia Monteiro
language : en
Publisher:
Release Date : 2019

Investigations Of Bioresponsive Polymers In Triple Negative Breast Cancers written by Patricia Monteiro and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.

Development Of Novel Thermosensitive Polymers For Bioresponsive Drug Delivery

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Author : Vivek Kumar Garripelli
language : en
Publisher:
Release Date : 2012

Development Of Novel Thermosensitive Polymers For Bioresponsive Drug Delivery written by Vivek Kumar Garripelli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.

Stimuli-responsive polymers have already showed tremendous promise in controlled and self-regulated drug delivery. Successful construction of responsive polymers requires amalgamation of chemical, physical and biological principles. For careful therapy, a great deal of advantages offered by stimuli-responsive polymers is essential. A small or modest change in the environmental condition (e.g. temperature, pH, light) brings a sharp change in the properties of the responsive polymers. `Smart' drug delivery systems utilize these principles to mimic the biological response behavior to a certain extent. Synthetic polymers incorporated with stimuli-responsive behavior would be amenable to overcome some of the systemic and intracellular delivery barriers. Development in material science has led to the engineering of variety of smart polymers which respond to diverse biological stimuli. The current research illustrates the development of two dual-stimuli-responsive polymers applied for local drug delivery. The polymers form thermogels at body temperature and degrade in either acidic or matrix metalloproteinase rich environments. The polymers were synthesized from Pluronic® tri-block copolymers in two simple reaction schemes and thoroughly characterized for structures, physicochemical properties and cytotoxicity. The underlying principles involved in physicochemical behavior of polymers and polymer solutions were clearly discussed. The release characteristics of different therapeutic agents such as small molecule drugs, genes and proteins from the thermogels were investigated. Finally, to improve the release properties of small size proteins, a nanocomposite thermogel system was developed. The nanocomposite thermogel was based on a nanoclay, laponite, and pH-sensitive thermogelling polymer. Finally, the nanocomposite thermogel incorporated with laponite sustained the release properties of small proteins comparing to regular thermogels. Taken all together, the novel thermosensitive polymers and nanocomposite thermogel system have great potential for bioresponsive local drug delivery where the amount of bioactive release entirely depends on physiological needs.

Bioresponsive Polymer Protection Conjugates As A Unimolecular Drug Delivery System

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Author : Helena Rosalind Petra Gilbert
language : en
Publisher:
Release Date : 2007

Bioresponsive Polymer Protection Conjugates As A Unimolecular Drug Delivery System written by Helena Rosalind Petra Gilbert and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Drug delivery systems categories.

Understanding Barriers To Efficient Nucleic Acid Delivery With Bioresponsive Block Copolymers

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Author : Daniel Kenneth Bonner
language : en
Publisher:
Release Date : 2012

Understanding Barriers To Efficient Nucleic Acid Delivery With Bioresponsive Block Copolymers written by Daniel Kenneth Bonner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.

The delivery of nucleic acids has the potential to revolutionize medicine by allowing previously untreatable diseases to be clinically addressed. Viral delivery systems have been held back by immunogenicity and toxicity concerns, but synthetic vectors have lagged in transfection efficiency. This thesis describes the rational design and systematic study of three classes of bioresponsive polymers for nucleic acid delivery. A central theme of the study was understanding how the structure of the polymers impacted each of the intracellular steps of delivery, rather than solely the end result. A powerful tool for efficiently quantifying endosomal escape was developed and applied to each of the material systems described. First, a linear-dendritic poly(amido amine) -poly(ethylene glycol) (PAMAM-PEG) block copolymer system previously developed in our lab was evaluated and its ability to overcome the sequential barriers of uptake, endosomal escape, and nuclear import were characterized. Next, a class of crosslinked linear polyethyleimine (xLPEI) hyperbranched polymers, which can contain disulfideresponsive linkages, were synthesized and investigated. It was demonstrated that free polymer in solution, not the presence of a functional bioresponsive domain, was responsible for the highly efficient and relatively nontoxic DNA delivery of this promising class of crosslinked polyamines. Finally, this analysis was applied to siRNA delivery by a library of amine-functionalized synthetic polypeptides. The pH-responsive secondary structure, micelle formation, and ester hydrolysis were studied prior to the discrete barrier-oriented analysis of the siRNA delivery potential of this library. It is hoped that the tools, materials, and systemic analysis of structure-function relationships in this thesis will enhance the process of discovery and development of clinically relevant gene carriers.

Bioresponsive Polymer Therapeutics Containing Coiled Coil Motifs

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Author : Samuel Philip Edward Deacon
language : en
Publisher:
Release Date : 2009

Bioresponsive Polymer Therapeutics Containing Coiled Coil Motifs written by Samuel Philip Edward Deacon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Polymers categories.

Delivery Of Sirna With Bioresponsive Cationic Polymer Based Carriers

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Author : Alexander Philipp
language : en
Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
Release Date : 2010

Delivery Of Sirna With Bioresponsive Cationic Polymer Based Carriers written by Alexander Philipp and has been published by Sudwestdeutscher Verlag Fur Hochschulschriften AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

Small interfering RNA molecules offer a promising tool for the treatment of various diseases including cancer and a number of other inherent or acquired disorders, due to their ability to knockdown essentially any target gene of interest. However, the lack of appropriate delivery systems limits the novel and encouraging therapeutic and clinical potential of siRNA. As optimization of the delivery strategy remains one of the major restrictions for clinical use, research has progressively focused on the development of synthetic delivery devices suitable for safe and specific delivery of siRNA to the target site. The main focus of this thesis was the discovery and optimization of novel polymers as highly effective and biocompatible siRNA delivery systems. On this occasion various polymers were developed featuring reduced toxicity, improved biodegradability and enhanced endosomolytic properties in order to overcome the major bottlenecks for siRNA delivery. Finally, pre-programmed bioresponsive carriers were realized, which act more dynamically in response to their cellular microenvironment representing a considerably step in the optimization process for nucleic acid delivery.

Polymers In Nanomedicine

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Author : Shigeru Kunugi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-01

Polymers In Nanomedicine written by Shigeru Kunugi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-01 with Technology & Engineering categories.

Functional Polymer Conjugates for Medicinal Nucleic Acid Delivery, by Ernst Wagner Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine, by Takami Akagi, Masanori Baba and Mitsuru Akashi Biodegradable Polymeric Assemblies for Biomedical Materials, by Yuichi Ohya, Akihiro Takahashi and Koji Nagahama PEGylation Technology in Nanomedicine, by Yutaka Ikeda and Yukio Nagasaki Cytocompatible Hydrogel Composed of Phospholipid Polymers for Regulation of Cell Functions, by Kazuhiko Ishihara, Yan Xu and Tomohiro Konno Design of Biointerfaces for Regenerative Medicine, by Yusuke Arima, Koichi Kato, Yuji Teramura and Hiroo Iwata Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration: Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration, by Jeremy J. Mercuri and Dan T. Simionescu Functionalized Biocompatible Nanoparticles for Site-Specific Imaging and Therapeutics, by Ranu K. Dutta, Prashant K. Sharma, Hisatoshi Kobayashi and Avinash C. Pandey

Bioresponsive Polymers

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