Development Of Novel Thermosensitive Polymers For Bioresponsive Drug Delivery
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Development Of Novel Thermosensitive Polymers For Bioresponsive Drug Delivery
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Author : Vivek Kumar Garripelli
language : en
Publisher:
Release Date : 2012
Development Of Novel Thermosensitive Polymers For Bioresponsive Drug Delivery written by Vivek Kumar Garripelli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Stimuli-responsive polymers have already showed tremendous promise in controlled and self-regulated drug delivery. Successful construction of responsive polymers requires amalgamation of chemical, physical and biological principles. For careful therapy, a great deal of advantages offered by stimuli-responsive polymers is essential. A small or modest change in the environmental condition (e.g. temperature, pH, light) brings a sharp change in the properties of the responsive polymers. `Smart' drug delivery systems utilize these principles to mimic the biological response behavior to a certain extent. Synthetic polymers incorporated with stimuli-responsive behavior would be amenable to overcome some of the systemic and intracellular delivery barriers. Development in material science has led to the engineering of variety of smart polymers which respond to diverse biological stimuli. The current research illustrates the development of two dual-stimuli-responsive polymers applied for local drug delivery. The polymers form thermogels at body temperature and degrade in either acidic or matrix metalloproteinase rich environments. The polymers were synthesized from Pluronic® tri-block copolymers in two simple reaction schemes and thoroughly characterized for structures, physicochemical properties and cytotoxicity. The underlying principles involved in physicochemical behavior of polymers and polymer solutions were clearly discussed. The release characteristics of different therapeutic agents such as small molecule drugs, genes and proteins from the thermogels were investigated. Finally, to improve the release properties of small size proteins, a nanocomposite thermogel system was developed. The nanocomposite thermogel was based on a nanoclay, laponite, and pH-sensitive thermogelling polymer. Finally, the nanocomposite thermogel incorporated with laponite sustained the release properties of small proteins comparing to regular thermogels. Taken all together, the novel thermosensitive polymers and nanocomposite thermogel system have great potential for bioresponsive local drug delivery where the amount of bioactive release entirely depends on physiological needs.
Bioresponsive Polymers
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Author : Deepa H. Patel
language : en
Publisher: CRC Press
Release Date : 2020-10-08
Bioresponsive Polymers written by Deepa H. Patel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Science categories.
This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.
Development Of A Novel Drug Delivery System Based On Polymeric Thermoresponsive Hydrogel Nanoparticles
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Author : Dimitrios Misirlis
language : en
Publisher:
Release Date : 2005
Development Of A Novel Drug Delivery System Based On Polymeric Thermoresponsive Hydrogel Nanoparticles written by Dimitrios Misirlis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Applications Of Polymers In Drug Delivery
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Author : Ambikanandan Misra
language : en
Publisher: Elsevier
Release Date : 2020-10-02
Applications Of Polymers In Drug Delivery written by Ambikanandan Misra and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-02 with Technology & Engineering categories.
Applications of Polymers in Drug Delivery, Second Edition, provides a comprehensive resource for anyone looking to understand how polymeric materials can be applied to current, new, and emerging drug delivery applications. Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to the most recent smart systems. Regulatory and intellectual property aspects as well as the clinical applicability of polymeric drug delivery systems are also discussed. The chapters are organized by specific delivery route, offering methodical and detailed coverage throughout. This second edition has been thoroughly revised to include the latest developments in the field. This is an essential book for researchers, scientists, and advanced students, in polymer science, drug delivery, pharmacology/pharmaceuticals, materials science, tissue engineering, nanomedicine, chemistry, and biology. In industry, this book supports scientists, R&D, and other professionals, working on polymers for drug delivery applications. Explains how polymers can be prepared and utilized for all major drug delivery routes Presents the latest advances, including drug targeting, polymeric micelles and polymersomes, and the delivery of biologicals and nucleic acid therapeutics Includes appendices with in-depth information on pharmaceutical properties of polymers and regulatory aspects
Development Of Novel Polymeric Materials For Gene Therapy And Ph Sensitive Drug Delivery
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Author :
language : en
Publisher:
Release Date : 2002
Development Of Novel Polymeric Materials For Gene Therapy And Ph Sensitive Drug Delivery written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
The underlying theme of this thesis is the use of polymeric materials in bioapplications. Chapters 2-5 either develop a fundamental understanding of current materials used for bioapplications or establish protocols and procedures used in characterizing and synthesizing novel materials. In chapters 6 and 7 these principles and procedures are applied to the development of materials to be used for gene therapy and drug delivery. Chapter one is an introduction to the ideas that will be necessary to understand the subsequent chapters, as well as a literature review of these topics. Chapter two is a paper that has been published in the ''Journal of Controlled Release'' that examines the mechanism of drug release from a polymer gel, as well as experimental design suggestions for the evaluation of water soluble drug delivery systems. Chapter three is a paper that has been published in the ''Journal of Pharmaceutical Sciences'' that discusses the effect ionic salts have on properties of the polymer systems examined in chapter two. Chapter four is a paper published in the Materials Research Society Fall 2000 Symposium Series dealing with the design and synthesis of a pH-sensitive polymeric drug delivery device. Chapter five is a paper that has been published in the journal ''Biomaterials'' proposing a novel polymer/metal composite for use as a biomaterial in hip arthroplasty surgery. Chapter six is a paper that will appear in an upcoming volume of the Journal ''Biomaterials'' dealing with the synthesis of a novel water soluble cationic polymer with possible applications in non-viral gene therapy. Chapter seven is a paper that has been submitted to ''Macromolecules'' discussing several novel block copolymers based on poly(ethylene glycol) and poly(diethylamino ethyl methacrylate) that possess both pH-sensitive and temperature sensitive properties. Chapter eight contains a summary of the research contained in chapters 2-7 and proposes future research for the gene therapy and drug delivery projects.
Molecularly Imprinted Polymers As Advanced Drug Delivery Systems
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Author : Zhaosheng Liu
language : en
Publisher: Springer Nature
Release Date : 2021-04-23
Molecularly Imprinted Polymers As Advanced Drug Delivery Systems written by Zhaosheng Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-23 with Medical categories.
This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives
Polymers In Drug Delivery
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Author : Ijeoma F. Uchegbu
language : en
Publisher: CRC Press
Release Date : 2006-05-19
Polymers In Drug Delivery written by Ijeoma F. Uchegbu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-19 with Medical categories.
Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera
Advanced Biopolymeric Systems For Drug Delivery
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Author : Amit Kumar Nayak
language : en
Publisher: Springer Nature
Release Date : 2020-07-11
Advanced Biopolymeric Systems For Drug Delivery written by Amit Kumar Nayak and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-11 with Technology & Engineering categories.
This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.
Bioresponsive Polymers
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Author : Deepa H Patel
language : en
Publisher: Apple Academic Press
Release Date : 2022-06
Bioresponsive Polymers written by Deepa H Patel and has been published by Apple Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06 with categories.
This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.
Functional Hydrogels In Drug Delivery
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Author : Umile Gianfranco Spizzirri
language : en
Publisher: CRC Press
Release Date : 2017-08-10
Functional Hydrogels In Drug Delivery written by Umile Gianfranco Spizzirri and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-10 with Medical categories.
The book deals with the synthesis and characterization of hydrogels specifically used as drug delivery systems. Each chapter includes the most recent updates about the different starting materials employed and the improvement of their physicochemical and biological properties to synthetize high performing carriers for specific uses.