Development Of Novel Polymeric Materials For Gene Therapy And Ph Sensitive Drug Delivery
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Development Of Novel Polymeric Materials For Gene Therapy And Ph Sensitive Drug Delivery
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Author :
language : en
Publisher:
Release Date : 2002
Development Of Novel Polymeric Materials For Gene Therapy And Ph Sensitive Drug Delivery written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
The underlying theme of this thesis is the use of polymeric materials in bioapplications. Chapters 2-5 either develop a fundamental understanding of current materials used for bioapplications or establish protocols and procedures used in characterizing and synthesizing novel materials. In chapters 6 and 7 these principles and procedures are applied to the development of materials to be used for gene therapy and drug delivery. Chapter one is an introduction to the ideas that will be necessary to understand the subsequent chapters, as well as a literature review of these topics. Chapter two is a paper that has been published in the ''Journal of Controlled Release'' that examines the mechanism of drug release from a polymer gel, as well as experimental design suggestions for the evaluation of water soluble drug delivery systems. Chapter three is a paper that has been published in the ''Journal of Pharmaceutical Sciences'' that discusses the effect ionic salts have on properties of the polymer systems examined in chapter two. Chapter four is a paper published in the Materials Research Society Fall 2000 Symposium Series dealing with the design and synthesis of a pH-sensitive polymeric drug delivery device. Chapter five is a paper that has been published in the journal ''Biomaterials'' proposing a novel polymer/metal composite for use as a biomaterial in hip arthroplasty surgery. Chapter six is a paper that will appear in an upcoming volume of the Journal ''Biomaterials'' dealing with the synthesis of a novel water soluble cationic polymer with possible applications in non-viral gene therapy. Chapter seven is a paper that has been submitted to ''Macromolecules'' discussing several novel block copolymers based on poly(ethylene glycol) and poly(diethylamino ethyl methacrylate) that possess both pH-sensitive and temperature sensitive properties. Chapter eight contains a summary of the research contained in chapters 2-7 and proposes future research for the gene therapy and drug delivery projects.
Development Of Novel Polymeric Materials For Gene Therapy And Ph Sensitive Drug Delivery
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Author : Brian Curtis Anderson
language : en
Publisher:
Release Date : 2002
Development Of Novel Polymeric Materials For Gene Therapy And Ph Sensitive Drug Delivery written by Brian Curtis Anderson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
The aim of this work was to obtain a fundamental understanding of drug release mechanisms from polymers that undergo thermoreversible gelation and to synthesize new polymers based on these that exhibit both pH and temperature sensitivity. Novel block and random copolymers with cationic character have been developed for drug delivery and gene therapy applications. The development of these materials began with a study of the mechanism of drug release from poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) block copolymers. This study revealed the release rates of drugs from water-soluble hydrogels composed of the PEO-PPO-PEO block copolymer Pluronic F127 was dictated almost solely by the rate of interfacial dissolution at the water/gel interface. A setup was designed to measure drug release from such soluble systems in order to avoid confounding hydrodynamic effects as a result of shear on the delicate polymer/gel interface. This study was followed by a complementary analysis of the effect ionic salts play in the phase transitions and drug release profiles in aqueous F127 solutions. In an attempt to incorporate pH sensitivity into such drug release systems, several block copolymers of poly (N, N-diethylaminoethyl methacrylate) (PDEAEM), PEO, and PPO were synthesized via anionic polymerization. Diblock materials (PEO-b-PDEAEM), either with or without a carboxylic acid endcap, were synthesized and characterized. Tablet dissolution experiments demonstrated pH-sensitivity in their drug release profiles relative to PEO tablets. Pentablock materials (PDEAEM-b-PEO-b-PPO-b-PEO-b-PDEAEM) were synthesized that maintain the thermoreversible gelation and micellization properties of F127 while introducing pH-dependent release from aqueous gels of the copolymer. This is the first example of non-crosslinked materials that exhibit both pH- and temperature-sensitive behavior. Using a similar synthesis route, random copolymers of PDEAEM and poly(poly(ethylene glycol) methyl ether methacrylate)) (PEGME) were synthesized which are water soluble and non-crytotoxic, whereas homopolymers of PDEAEM are neither. These materials have potential as gene therapy vectors.
Functional Biomaterials
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Author : Sougata Jana
language : en
Publisher: Springer Nature
Release Date : 2022-03-29
Functional Biomaterials written by Sougata Jana and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-29 with Science categories.
This book explores in depth a wide range of functional biomaterials-based systems for drug, gene delivery, and biomedical aspects. The chapters cover newer technologies such as polymeric micelle, pH-responsive biomaterials, stimuli-responsive hydrogels, silk fibroin, inorganic biomaterials, synthetic biomaterials, 3D printed biomaterials, metallic biomaterials, ceramic and hybrid biomaterials. It also describes the theranostic approaches for cancer therapy, the biomaterials-based nanofibers scaffolds in tissue engineering, as well as the strategies applications of metallic biomaterials for the medical and dental prosthetic field. This newer and updated approach will be attractive for biomedical engineering students working on materials science in the development of novel drug delivery strategies. The book will be an important reference for researchers and professionals working on biomaterial research in the pharmaceutical and medical fields.
Polymers In Drug Delivery
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Author : Ijeoma F. Uchegbu
language : en
Publisher: CRC Press
Release Date : 2006-05-19
Polymers In Drug Delivery written by Ijeoma F. Uchegbu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-19 with Medical categories.
Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera
Polymeric Micelles For Drug Delivery
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Author : Prashant Kesharwani
language : en
Publisher: Woodhead Publishing
Release Date : 2022-08-18
Polymeric Micelles For Drug Delivery written by Prashant Kesharwani and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-18 with Technology & Engineering categories.
Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation. Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery Describes the various polymer types used in the synthesis and characterization of polymeric micelles Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more
Bioinspired And Biomimetic Polymer Systems For Drug And Gene Delivery
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Author : Zhongwei Gu
language : en
Publisher: John Wiley & Sons
Release Date : 2014-12-04
Bioinspired And Biomimetic Polymer Systems For Drug And Gene Delivery written by Zhongwei Gu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-04 with Medical categories.
Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.
Smart Polymeric Nano Constructs In Drug Delivery
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Author : Suresh P Vyas
language : en
Publisher: Academic Press
Release Date : 2022-11-12
Smart Polymeric Nano Constructs In Drug Delivery written by Suresh P Vyas and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-12 with Business & Economics categories.
Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. Provides comprehensive overview of the potential role of polymeric systems in drug delivery Explores the design, synthesis, and application of different smart material-based delivery systems Includes fundamental and clinical applications
Polymers And Nanomaterials For Gene Therapy
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Author : Ravin Narain
language : en
Publisher: Woodhead Publishing
Release Date : 2016-01-09
Polymers And Nanomaterials For Gene Therapy written by Ravin Narain and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-09 with Science categories.
Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications
Polymeric Gene Delivery Systems
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Author : Yiyun Cheng
language : en
Publisher: Springer
Release Date : 2018-09-04
Polymeric Gene Delivery Systems written by Yiyun Cheng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-04 with Technology & Engineering categories.
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Polymeric Biomaterials
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Author : Severian Dumitriu
language : en
Publisher: CRC Press
Release Date : 2013
Polymeric Biomaterials written by Severian Dumitriu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
The third edition of a bestseller, this substantially expanded reference, now in two volumes, presents the latest polymer developments and most up-to-date applications of polymeric biomaterials in medicine. This volume addresses the processing of polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for various uses in the medical and pharmaceutical arenas. It covers applications such as drug delivery, tissue engineering, anticancer therapies, hydrogels, and bioartificial organs. This comprehensive resource includes state-of-the-art research and successful breakthroughs in applications that have occurred in the last ten years.