Polymers And Nanomaterials For Gene Therapy
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Polymers And Nanomaterials For Gene Therapy
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Author : Ravin Narain
language : en
Publisher: Woodhead Publishing
Release Date : 2016-01-09
Polymers And Nanomaterials For Gene Therapy written by Ravin Narain and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-09 with Science categories.
Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications
Gene Therapy
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Author : Surendra Nimesh
language : en
Publisher: Elsevier
Release Date : 2013-10-31
Gene Therapy written by Surendra Nimesh and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-31 with Science categories.
Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy. Provides an overview of nanotechnology applications in gene therapy, from preparation of nanoparticles to in vitro and in vivo studies Details the tools and techniques available for preparation, characterization and in vitro and in vivo study of nanoparticles Details the limitations of nanoparticle-mediated gene therapy and proposes ways in which they may be overcome
Polymeric Gene Delivery
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Author : Mansoor M. Amiji
language : en
Publisher: CRC Press
Release Date : 2004-09-29
Polymeric Gene Delivery written by Mansoor M. Amiji and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-29 with Medical categories.
To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry
Polymeric Gene Delivery Systems
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Author : Yiyun Cheng
language : en
Publisher: Springer
Release Date : 2018-09-04
Polymeric Gene Delivery Systems written by Yiyun Cheng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-04 with Technology & Engineering categories.
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Theory Techniques And Applications Of Nanotechnology In Gene Silencing
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Author : Surendra Nimesh
language : en
Publisher: CRC Press
Release Date : 2022-09-01
Theory Techniques And Applications Of Nanotechnology In Gene Silencing written by Surendra Nimesh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-01 with Science categories.
This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted.
Bio Inspired Nanomaterials And Applications
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Author : Donglu Shi
language : en
Publisher: World Scientific
Release Date : 2014-11-18
Bio Inspired Nanomaterials And Applications written by Donglu Shi and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-18 with Science categories.
This book intends to provide an up-to-date information in the field of nanobiomedicine. The focus of the book is on the basic concepts and recent developments in the field of nanotechnology. This book covers a broad spectrum of nanomaterials processing, structural characteristics, and related properties and will include bio-probes, medical imaging, drug delivery, and tumor diagnosis. Critical issues are addressed in a straightforward manner so those with no technical background and university students can benefit from the information. Furthermore, many novel concepts in nanomaterials are explained in light of current theories. An important aspect of the book lies on its wide coverage in practical biomedical applications. Not only are the cutting-edge technologies in modern medicine introduced, but also unique materials applications in many clinical areas. Contents:Up-Conversion Nanoparticles for Early Cancer Diagnosis (Liang Cheng, Bingbo Zhang and Zhuang Liu)Redox-Sensitive Polymeric Nanoparticles for Intracellular Drug Delivery (Huiyun Wen, Yongyong Li and Xin Zhao)Design of Biocompatible PEIs as Artificial Gene Delivery Vectors (Ting Shi, Chao Lin and Peng Zhao)Magnetic Fe3O4 Nanoparticles for Cancer Photothermal Therapy (Maoquan Chu)Nanomaterial-Based Sensors for Environmental Monitoring (Jinhu Yang)Janus Nanostructures and Their Bio-Medical Applications (Yilong Wang and Feng Wang)Nanomaterial-Involved Optical Imaging/Spectroscopy Methods for Single-Molecule Detections in Biomedicine (Yao Qin)Surface Functionalized Carbon Nanotubes for Biomedical Applications (Bingdi Chen)Intracellular siRNA Delivery by Multifunctional Nanoparticles (Kun Lu, Lei Wang, Xiaohui Tan, Yao Chen, Changhui Wang and Lifeng Qi)Chemical and Biological Sensors Based on Nanowire Transistors (Xiaohan Wu and Jia Huang) Readership: Undergraduate or graduate students, and researchers in nanomaterials, biochemistry, biomedical engineering. Key Features:It is closely clinically oriented in medical diagnosis and treatmentIt is comprehensive in both nanomaterials and biomedical applicationsIt includes many novel concepts in nanotechnology and up to dateKeywords:Nanomedicine;Nanobiomedicine;Nanobiotechnology;Nanomaterials;Bio-Probes;Medical Imaging;Drug delivery;Tumor Diagnosis
Functional Polymers For Nanomedicine
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Author : Youqing Shen
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013
Functional Polymers For Nanomedicine written by Youqing Shen and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
A complete overview of the different strategies for designing polymers for targeted gene therapy and drug delivery for researchers in polymer science, nanotechnology and pharmacy.
Nonviral Vectors For Gene Therapy
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Author :
language : en
Publisher: Academic Press
Release Date : 2014-11-18
Nonviral Vectors For Gene Therapy written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-18 with Science categories.
The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Includes methods for testing with ethical, legal, and social implications Critically analyzes future directions Written and edited by recognized leaders in the field
Advances In Polymeric Nanomaterials For Biomedical Applications
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Author : Anil Kumar Bajpai
language : en
Publisher: Elsevier
Release Date : 2021-03-17
Advances In Polymeric Nanomaterials For Biomedical Applications written by Anil Kumar Bajpai and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-17 with Technology & Engineering categories.
Advances in Polymeric Nanomaterials for Biomedical Applications examines advanced polymer synthetic strategies for developing novel biomaterials for use in medicine. With a strong focus on fundamentals and structure, the authors also explore their fabrication, along with their current and potential biomedical applications. The book begins with a look at the fundamentals of polymeric nanomaterials and their properties and then discusses the design of biomaterials and their applications in drug delivery. Further chapters explore important applications, such as imaging and regenerative medicine, including current challenges and future trends. This valuable resource is especially useful for materials and polymer scientists, and bioengineers wishing to broaden their knowledge of polymeric nanobiomaterials. Covers the complete spectrum of polymer nanomaterials used in biomedical applications Includes various applications, such as drug delivery, gene delivery, bio-imaging, tissue engineering and regenerative medicine, anti-microbial agents, and neuroscience Explores fundamental correlations between structures, properties and applications, as well as synthetic strategies for polymer nanomaterials
Integration Of Biomaterials For Gene Therapy
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Author : Rishabha Malviya
language : en
Publisher: John Wiley & Sons
Release Date : 2023-10-10
Integration Of Biomaterials For Gene Therapy written by Rishabha Malviya and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-10 with Science categories.
INTEGRATION OF BIOMATERIALS FOR GENE THERAPY Brings industrial practitioners and researchers together to discuss how the deeper integration of biomaterial platforms could play a significant role in enabling breakthroughs in the application of gene editing for the treatment of human disease. This book comprises research and review articles from leading researchers with multidisciplinary experience. It discusses many broad topics, including nanoparticle-enabled gene therapy, inorganic nanocarrier-based gene delivery, non-viral delivery of nucleic acid, biocompatible hydrogels, silk, and polysaccharides-based gene delivery. Other gene delivery topics discussed include the use of smart and engineered biomaterials, combined therapy with growth factors and cell transportation, and the prospects and challenges in the treatment of different diseases, including cancer. This book bridges the knowledge of pharmaceutics, engineering, basic science, and clinical research fields in a way that will help the research community expedite the clinical application of these therapies for various diseases and conditions. Audience A broad range of researchers, scientists, and engineers in diverse fields such as materials science, biomedicine, biomedical engineering, biology, chemistry, physics, biotechnology, pharmacology, toxicology, and formulation scientists.