Polymeric Gene Delivery
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Polymeric Gene Delivery
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Author : Mansoor M. Amiji
language : en
Publisher: CRC Press
Release Date : 2004-09-29
Polymeric Gene Delivery written by Mansoor M. Amiji and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-29 with Medical categories.
To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry
Polymeric Gene Delivery Systems
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Author : Yiyun Cheng
language : en
Publisher: Springer
Release Date : 2018-09-04
Polymeric Gene Delivery Systems written by Yiyun Cheng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-04 with Technology & Engineering categories.
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Polymers And Nanomaterials For Gene Therapy
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Author : Ravin Narain
language : en
Publisher: Woodhead Publishing
Release Date : 2016-01-09
Polymers And Nanomaterials For Gene Therapy written by Ravin Narain and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-09 with Science categories.
Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications
How Free Cationic Polymer Chains Promote Gene Transfection
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Author : Yue Yanan
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-05-13
How Free Cationic Polymer Chains Promote Gene Transfection written by Yue Yanan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-13 with Technology & Engineering categories.
In this PhD thesis, Yue Yanan addresses a long-overlooked and critical question in the development of non-viral vectors for gene delivery. The author determines that those uncomplexed and cationic polymer chains free in the solution mixture of polymer and DNA facilitate and promote gene transfection. Furthermore, by using a combination of synthetic chemistry, polymer physics and molecular biology, Yue confirms that it is those cationic polymer chains free in the solution mixture, rather than those bound to DNA chains, that play a decisive role in intracellular trafficking. Instead of the previously proposed and widely accepted “proton sponge” model, the author's group propose a new hypothesis based on the results of several well-designed and decisive experiments. These results show that free polycationic chains with a length of more than ~10 nm are able to partially block the fusion between different endocytic vesicles, including the endocytic-vesicle-to-endolysosome pathway. This thesis is highly original and its results greatly deepen our understanding of polymer-mediated gene transfection. More importantly, it provides new insights into the rational design of next-generation superior polymeric gene-delivery vectors.
Multifunctional Polymeric Materials For Drug And Gene Delivery
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Author : Yakai Feng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-30
Multifunctional Polymeric Materials For Drug And Gene Delivery written by Yakai Feng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-30 with Science categories.
Polymers In Drug Delivery
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Author : Ijeoma F. Uchegbu
language : en
Publisher: CRC Press
Release Date : 2006-05-19
Polymers In Drug Delivery written by Ijeoma F. Uchegbu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-19 with Medical categories.
Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera
Polymer Therapeutics I
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Author : Ronit Satchi-Fainaro
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-02-10
Polymer Therapeutics I written by Ronit Satchi-Fainaro and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02-10 with Technology & Engineering categories.
Bioinspired And Biomimetic Polymer Systems For Drug And Gene Delivery
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Author : Zhongwei Gu
language : en
Publisher: John Wiley & Sons
Release Date : 2015-03-09
Bioinspired And Biomimetic Polymer Systems For Drug And Gene Delivery written by Zhongwei Gu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-09 with Medical categories.
Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.
Polymer Therapeutics I
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Author : Ronit Satchi-Fainaro
language : en
Publisher: Springer
Release Date : 2009-09-02
Polymer Therapeutics I written by Ronit Satchi-Fainaro and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-02 with Technology & Engineering categories.
Polymeric Drug Delivery Systems
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Author : Glen S. Kwon
language : en
Publisher: CRC Press
Release Date : 2005-04-12
Polymeric Drug Delivery Systems written by Glen S. Kwon and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-12 with Medical categories.
Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.