Blood Cells Rheology And Aging
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Blood Cells Rheology And Aging
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Author : Dieter Platt
language : en
Publisher: Springer
Release Date : 1988
Blood Cells Rheology And Aging written by Dieter Platt and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.
In the third Erlangen-Nuremberg symposium on experimental geronto logy we discussed the effect of aging on blood cells and rheology. Most studies with red cells have been performed on humans, rats, and rabbits. All these erythrocytes have no nucleus; the cells are therefore a model in which new synthesis of proteins is impossible. All the processes are age dependent except for exchange with the plasma. Investigations of red cells have attracted attention because of the latter's availability in large quantities from biochemists, physiologists, immunologists, and micro scopists. We now have a relative abundance of data on the biochemical and immunologic composition as well as on the ultrastructure of the cells. The second topic under discussion at the symposium was the immune system and cell receptors. One of the most apparent features of aging of the organism is progressive dysregulation of the immune system. As a result, the incidence of infection, cancer, and autoimmune and immune complex diseases increases. While we have a lot of new data on the function and differentiation of lymphoid cells, we have little informa tion on lymphocyte receptors during the aging process. Rheologic studies reflect changes in red cell deformability and blood coagulation. The erythrocyte deformability influences blood flow in all parts of the circulation. The fluidity of the red cell membranes controls whole blood viscosity. During aging, there are significant alterations in blood coagulation and hemostasis. One of the best known modifications of blood co agulation is a typical thrombophilic tendency with aging.
Blood Cells Rheology And Aging
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Author : Dieter Platt
language : en
Publisher:
Release Date : 1987-12-11
Blood Cells Rheology And Aging written by Dieter Platt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-12-11 with categories.
This volume on experimental gerontology deals with the effects of aging on blood cells and rheology. Since gerontology is an interdisciplinary science, numerous experts engaged in various disciplines present their up-to-date results related to aging. The detailed accounts compiled in this book will augment the knowledge of red cells, immunology, receptors, blood coagulation, and rheology. The volume provides a valuable basis for future scientific work in gerontological research.
Red Blood Cell Aggregation
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Author : Oguz Baskurt
language : en
Publisher: CRC Press
Release Date : 2011-09-28
Red Blood Cell Aggregation written by Oguz Baskurt and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-28 with Medical categories.
Red blood cells in humans-and most other mammals-have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this real
Clinical Aspects Of Blood Viscosity And Cell Deformability
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Author : G. D. O. Lowe
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Clinical Aspects Of Blood Viscosity And Cell Deformability written by G. D. O. Lowe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
After many years of relative neglect, the importance of study of factors governing blood flow has at last achieved recognition; in this volume are documented many of the techniques, and the basic scientific and clinical observations, which have helped to open up understanding of this highly important aspect of human physiology and pathology in recent years. The text is logically divided into five sections beginning with blood cell deformability, then moving on to theoretical consideration of blood rheology, followed by accounts of the interrelationships between rheology, blood flow and vascular occlusion. The final two sections deal with blood rheology in clinical practice and therapeutic aspects of the study of blood flow. As regards blood cell deformability (Section A), the basic problem is set out by Kiesewetter and colleagues in the first paragraph of chapter 1 (p. 3), in which they point out that whereas human erythrocytes at rest have a diameter of approxi mately 7. 5 /-tm, nutritive capillaries have diameters ranging from 3-5 /-tm, and chapters in section A give an account of the ways in which the red cell can undergo deformation to permit capillary perfusion and the maintenance of the microcirculation.
Red Blood Cell Aging
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Author : Antonio De Flora
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-08
Red Blood Cell Aging written by Antonio De Flora and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.
Clinical Blood Rheology
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Author : Gordon D.O. Lowe
language : en
Publisher: CRC Press
Release Date : 2019-06-04
Clinical Blood Rheology written by Gordon D.O. Lowe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.
Published in 1988: Study of blood flow properties (rheology) has attracted growing interest from clinicians in recent years. A United Kingdom meeting and a European meeting in 1979 resulted in previous publications summarizing the literature up to that time.
Blood Viscosity Factors
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Author : Leslie Simpson (Ph.D.)
language : en
Publisher:
Release Date : 2008
Blood Viscosity Factors written by Leslie Simpson (Ph.D.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Blood categories.
Blood Viscosity Factors brings together a series of essays on the impact of various abnormalities on blood viscosity factors. It contains several hundred references to already published work in the field. Beginning with the finding that red blood cells proliferate in shape and are not just one toroidally shaped horde, the work offers unique insights into the role of ageing and disease. The work of Dr Simpson corrects the record and offers tantalising possibilities for the future. One result of the move to targeted and commercial research has been to stunt the growth of whole fields of inquiry in favour of more convenient or competitive ways of looking at a situation. The real puzzle is that the work has been done and a substantial body of peer reviewed publications attest to the quality and depth of the findings. The book is of interest to those readers who prefer a more holistic view of science and the world, than is currently offered by the standard texts.
Regulation Of Red Cell Life Span Erythropoiesis Senescence And Clearance
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Author : Lars Kaestner
language : en
Publisher: Frontiers E-books
Release Date : 2014-12-03
Regulation Of Red Cell Life Span Erythropoiesis Senescence And Clearance written by Lars Kaestner and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-03 with Biology (General) categories.
Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.
Red Cell Rheology I
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Author : Stephen B. Shohet
language : en
Publisher:
Release Date : 1977
Red Cell Rheology I written by Stephen B. Shohet and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Blood categories.
Clinical Blood Rheology
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Author : Gordon D.O. Lowe
language : en
Publisher: CRC Press
Release Date : 2019-06-04
Clinical Blood Rheology written by Gordon D.O. Lowe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.
Published in 1988: Study of blood flow properties (rheology) has attracted growing interest from clinicians in recent years. A United Kingdom meeting and a European meeting in 1979 resulted in previous publications summarizing the literature up to that time.