Bone Metastasis And Molecular Mechanisms


Bone Metastasis And Molecular Mechanisms
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Bone Metastasis And Molecular Mechanisms


Bone Metastasis And Molecular Mechanisms
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Author : Gurmit Singh
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Bone Metastasis And Molecular Mechanisms written by Gurmit Singh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.


Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer. Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.



Bone Metastasis


Bone Metastasis
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Author : Gurmit Singh
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-28

Bone Metastasis written by Gurmit Singh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-28 with Medical categories.


A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.



Molecular Mechanisms Of Cancer


Molecular Mechanisms Of Cancer
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Author : Georg F. Weber
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-12

Molecular Mechanisms Of Cancer written by Georg F. Weber and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-12 with Medical categories.


This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.



Bone Metastases


Bone Metastases
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Author : Vassilios Vassiliou
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-19

Bone Metastases written by Vassilios Vassiliou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-19 with Medical categories.


The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.



Cancer Metastasis


Cancer Metastasis
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Author : Yusuf Tutar
language : en
Publisher:
Release Date : 2023

Cancer Metastasis written by Yusuf Tutar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Metastasis categories.




Tumor Microenvironment Molecular Mechanisms And Signaling Pathways Involved In Metastatic Progression


Tumor Microenvironment Molecular Mechanisms And Signaling Pathways Involved In Metastatic Progression
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Author : Antonella Zannetti
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-30

Tumor Microenvironment Molecular Mechanisms And Signaling Pathways Involved In Metastatic Progression written by Antonella Zannetti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-30 with Medical categories.




Bone Cancer


Bone Cancer
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Author : Dominique Heymann
language : en
Publisher: Academic Press
Release Date : 2009-08-20

Bone Cancer written by Dominique Heymann and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-20 with Medical categories.


The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays



Bone Metastasis For Solid Tumors From Mechanisms To Clinical Treatment


Bone Metastasis For Solid Tumors From Mechanisms To Clinical Treatment
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Author : Dianwen Song
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-27

Bone Metastasis For Solid Tumors From Mechanisms To Clinical Treatment written by Dianwen Song and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Medical categories.




Bone Cancer


Bone Cancer
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Author : Dominique Heymann
language : en
Publisher: Elsevier
Release Date : 2014-09-04

Bone Cancer written by Dominique Heymann and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with Medical categories.


Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases – from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays



Chemoresistance And Metastasis In Breast Cancer Molecular Mechanisms And Novel Clinical Strategies


Chemoresistance And Metastasis In Breast Cancer Molecular Mechanisms And Novel Clinical Strategies
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Author : Qifeng Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-18

Chemoresistance And Metastasis In Breast Cancer Molecular Mechanisms And Novel Clinical Strategies written by Qifeng Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-18 with Medical categories.