Brain Vs Retina Differences And Commonalities The Role Of Oxidative Stress In Neurodegenerative Diseases
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Brain Vs Retina Differences And Commonalities The Role Of Oxidative Stress In Neurodegenerative Diseases
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Author : Jose Hurst
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-15
Brain Vs Retina Differences And Commonalities The Role Of Oxidative Stress In Neurodegenerative Diseases written by Jose Hurst and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-15 with Science categories.
Oxidative stress, free radicals, antioxidants - when it comes to our health, this topic is taking up more and more attention. But what is oxidative stress, how does it arise and what effects does it have on the most sensitive area of our body: the neuronal tissue or the retina. Many neurological diseases affecting the brain or the retina are associated with elevated levels of reactive oxygen species (ROS). High levels of ROS can cause damage to proteins, nucleic acids, lipids, membranes, and organelles such as mitochondria, and can be caused not only by external stimuli but also by aging. Most theories on the aging scenario assume that cumulative oxidative stress leads to mitochondrial changes, mitochondrial dysfunction, and oxidative damage. Therefore, it is not surprising that excess ROS is among others associated with the development of a variety of age-related neuronal diseases, including Alzheimer's and Parkinson's disease, as well as retinal diseases diabetic retinopathy, glaucoma, and age-related macular (AMD) degeneration. The aim of this Research Topic is to answer open questions, to combine already gained knowledge, to close the gaps between ophthalmology and neurology when it comes to oxidative stress in order to understand the underlying pathways and derive innovative therapies. It searches for the updates and new findings in both fields that answer the central question: are the same cell types affected by oxidative stress in the same way in the brain and retina? Experimental studies or patient studies that provide new insights are welcome, as well as studies that investigate antioxidant therapies.
Common Pathways Linking Neurodegenerative Diseases The Role Of Inflammation
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Author : Grzegorz Kreiner
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-01
Common Pathways Linking Neurodegenerative Diseases The Role Of Inflammation written by Grzegorz Kreiner and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-01 with Science categories.
Steroids And The Brain
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Author : Takayoshi Ubuka
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-10
Steroids And The Brain written by Takayoshi Ubuka and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with categories.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1999
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medicine categories.
Inflammation In The Pathogenesis Of Chronic Diseases
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Author : Randall E. Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-09
Inflammation In The Pathogenesis Of Chronic Diseases written by Randall E. Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-09 with Medical categories.
In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.
Behold The Eye In Parkinson S Disease Alzheimer S Disease
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Author : Ivan Bodis-Wollner
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-20
Behold The Eye In Parkinson S Disease Alzheimer S Disease written by Ivan Bodis-Wollner and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-20 with categories.
There are increasing lines of evidence showing that neurodegeneration in Alzheimer’s disease (AD) and Parkinson’s disease (PD) is not limited to the brain but also occurs in the retina. Consequently, AD/PD patients can gradually develop vision problems. This neurological and ophthalmological disorder creates a pressing need for developing therapy to treat vision impairment in AD/PD. On the other hand, pathophysiological changes in the retina may reflect what might happen in the same diseases in the brain. Thus retinal studies may allow us to develop quantifiable measures for the diagnosis and prognosis of disease progression. Furthermore, parallel or early pathophysiological changes of the retina in AD/PD allow us to study retina-brain interactions.
Microglial Polarization In The Pathogenesis And Therapeutics Of Neurodegenerative Diseases
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Author : Yu Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2018
Microglial Polarization In The Pathogenesis And Therapeutics Of Neurodegenerative Diseases written by Yu Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization.
Rising Stars In Food Chemistry
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Author : Fuguo Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-09
Rising Stars In Food Chemistry written by Fuguo Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-09 with Medical categories.
Inherited Retinal Dystrophies A Light At The End Of The Tunnel
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Author : José M. Millan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-30
Inherited Retinal Dystrophies A Light At The End Of The Tunnel written by José M. Millan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-30 with Science categories.
Trace Elements And Minerals In Health And Longevity
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Author : Marco Malavolta
language : en
Publisher: Springer
Release Date : 2018-11-13
Trace Elements And Minerals In Health And Longevity written by Marco Malavolta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-13 with Medical categories.
This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are describedfrom the point of view of their specific interactions with trace elements and minerals.