Calcium Sensing Receptor
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New Perspectives In Magnesium Research
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Author : Yoshiki Nishizawa
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-03-06
New Perspectives In Magnesium Research written by Yoshiki Nishizawa and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-06 with Medical categories.
A definitive review in the field of magnesium research, this book brings together the proceedings of the 11th International Magnesium Symposium in Osaka, Japan from October 22-26, 2006. Written by authorities in the area, the book provides a thorough overview of progress in the area of magnesium research. The author is one of the world's foremost magnesium researchers and reviewers, and the book provides essential reading for researchers in magnesium.
Calcium Sensing Receptor
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Author : Naibedya Chattopadhyay
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Calcium Sensing Receptor written by Naibedya Chattopadhyay and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Calcium-Sensing Receptor provides an overview of various aspects of the calcium receptor's biochemistry, physiology and pathophysiology that is suitable both for those who have been working in the field of Ca2+0-sensing as well as those who are new to this discipline. Calcium-Sensing Receptor is the nineteenth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.
Physiology And Pathophysiology Of The Extracellular Calcium Sensing Receptor
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Author : Enikö Kallay
language : en
Publisher: Frontiers Media SA
Release Date : 2018-07-09
Physiology And Pathophysiology Of The Extracellular Calcium Sensing Receptor written by Enikö Kallay and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-09 with categories.
Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in calcium homeostasis such as parathyroid, kidney, and bone it regulates circulating calcium concentrations. The germline mutations of the CaSR cause parathyroid disorders demonstrating the importance of the CaSR for the maintenance of serum calcium homeostasis. The CaSR has an important role also in a range of non-calcitropic tissues, such as the intestine, lungs, central and peripheral nervous system, breast, skin and reproductive system, where it regulates molecular and cellular processes such as gene expression, proliferation, differentiation and apoptosis; as well as regulating hormone secretion and lactation. This Research Topic is an overview of the CaSR and its molecular signaling properties together with the various organ systems where it plays an important role. The articles highlight the current knowledge regarding many aspects of the calcitropic and non-calcitropic physiology and pathophysiology of the CaSR.
The Parathyroids
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Author : John P. Bilezikian
language : en
Publisher: Elsevier
Release Date : 2001-07-21
The Parathyroids written by John P. Bilezikian and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-21 with Medical categories.
Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians. Key Features * Offers objective and authoritative reviews on controversial clinical issues * Written by world experts on parathyroid hormone and its disorders * Superb, state-of-the-art compendium in one convenient volume * Bridges basic science of parathyroid hormone to major clinical disorders * Practical information on clinical management of parathyroid hormone disorders
Calcium Signaling
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Author : Md. Shahidul Islam
language : en
Publisher: Springer Nature
Release Date : 2019-10-23
Calcium Signaling written by Md. Shahidul Islam and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-23 with Medical categories.
This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Genetics Of Bone Biology And Skeletal Disease
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Author : Rajesh V. Thakker
language : en
Publisher: Academic Press
Release Date : 2017-10-31
Genetics Of Bone Biology And Skeletal Disease written by Rajesh V. Thakker and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-31 with Medical categories.
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Pharmacology Of G Protein Coupled Receptors
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Author : Richard R. Neubig
language : en
Publisher: Academic Press
Release Date : 2011-09-19
Pharmacology Of G Protein Coupled Receptors written by Richard R. Neubig and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-19 with Medical categories.
G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. In addition, emerging drug targets such as receptor families for fatty acids, carboxylic acids, lipid mediators, etc. are included. Final chapters cover novel mechanisms of signal regulation through PDZ domains and RGS proteins. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists
The Role Of The Calcium Sensing Receptor Casr In Parathyroid Tumourigenesis
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Author : Ana Rita Gomes
language : en
Publisher:
Release Date : 2014
The Role Of The Calcium Sensing Receptor Casr In Parathyroid Tumourigenesis written by Ana Rita Gomes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Pediatric Nephrology
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Author : Ellis D. Avner
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-08-20
Pediatric Nephrology written by Ellis D. Avner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-20 with Medical categories.
Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.
Pocket Companion To Brenner And Rector S The Kidney E Book
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Author : Michael R. Clarkson
language : en
Publisher: Elsevier Health Sciences
Release Date : 2010-02-22
Pocket Companion To Brenner And Rector S The Kidney E Book written by Michael R. Clarkson and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-22 with Medical categories.
Pocket Companion to Brenner and Rector’s The Kidney distills the essential clinical information from the latest edition of the seminal text on kidney diseases and their management. Michael R. Clarkson, Ciara Magee, and Barry M. Brenner detail the key pathophysiologic, diagnostic, and treatment issues in clinical nephrology, including interventional nephrology, endocrine aspects of kidney disease, and plasmapheresis. Diagnose, treat, and manage both common and uncommon disorders. Find clinical knowledge quickly and easily thanks to convenient tables throughout the text. Choose the best option of the many techniques available through discussions of indications for laboratory tests and imaging studies. Enhance your clinical acumen with coverage of new topics such as risk factors and kidney disease, nephron endowment, interventional nephrology, plasmapheresis, xenotransplantation, stem cells in renal biology and medicine, and more. Stay current thanks to two new sections—Epidemiology and Risk Factors in Kidney Disease and Frontiers in Kidney Disease—that include topics such as stem cell and genomics.