Carbohydrates In Drug Design And Discovery
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Carbohydrates In Drug Design And Discovery
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Author : Jesús Jímenez-Barbero
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-04-10
Carbohydrates In Drug Design And Discovery written by Jesús Jímenez-Barbero and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-10 with Science categories.
In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery. Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.
Carbohydrates In Drug Discovery And Development
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Author : Vinod K. Tiwari
language : en
Publisher: Elsevier
Release Date : 2020-07-31
Carbohydrates In Drug Discovery And Development written by Vinod K. Tiwari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-31 with Science categories.
Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.
Carbohydrate Based Drug Discovery
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Author : Chi-Huey Wong
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Carbohydrate Based Drug Discovery written by Chi-Huey Wong and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.
Carbohydrate Chemistry State Of The Art And Challenges For Drug Development An Overview On Structure Biological Roles Synthetic Methods And Application As Therapeutics
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Author : Laura Cipolla
language : en
Publisher: World Scientific
Release Date : 2015-07-23
Carbohydrate Chemistry State Of The Art And Challenges For Drug Development An Overview On Structure Biological Roles Synthetic Methods And Application As Therapeutics written by Laura Cipolla and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-23 with Science categories.
The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications.Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.
Carbohydrate Based Drug Discovery 2 Volume Set
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Author : Chi-Huey Wong
language : en
Publisher: John Wiley & Sons
Release Date : 2003-10-17
Carbohydrate Based Drug Discovery 2 Volume Set written by Chi-Huey Wong and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-17 with Science categories.
To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.
Carbohydrates In Drug Design
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Author : Zbigniew Witczak
language : en
Publisher: CRC Press
Release Date : 1997-06-11
Carbohydrates In Drug Design written by Zbigniew Witczak and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-06-11 with Science categories.
Emphasizes the role of carbohydrates as anti-inflammatory, anticancer, antidiabetic, anticonvulsant, antibiotic and antiviral agents. The text covers chemical properties, biological functions, methodologies for synthesizing model compounds, conformational and steric effects, synthetic and enzymatic approaches, and the discovery and development of leads in emerging fields.
Carbohydrates As Drugs
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Author : Peter H. Seeberger
language : en
Publisher: Springer
Release Date : 2014-11-14
Carbohydrates As Drugs written by Peter H. Seeberger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-14 with Science categories.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Carbohydrate Based Drugs Discovery
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Author : Jian Yin
language : en
Publisher:
Release Date : 2024-03-25
Carbohydrate Based Drugs Discovery written by Jian Yin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-25 with Science categories.
Carbohydrates play an essential role in the organism and have many bioactivities. Carbohydrate-based drug discovery is an up-and-coming area of research in medicinal chemistry. Bioactive carbohydrates open up a new source for drug development. More than 170 carbohydrate-based drugs have been successfully approved as anticoagulants, antitumor agents, antidiabetic agents, antibiotics, antiviral agents, and vaccines. However, most carbohydrates have low druggability. As such, new methods and strategies to improve carbohydrates' druggability are in high demand. This Special Issue aimed to serve as an open forum where researchers can share their experiences and findings on carbohydrate-based drugs, with a focus on the discovery and development of new carbohydrate-based therapeutic agents. Contributions to this issue, in the form of both original research and review articles, cover the separation, identification, synthesis, and pharmacology of bioactive carbohydrates, including monosaccharides, oligosaccharides, polysaccharides, glycopeptides, glycoproteins, glycomimetics, and others.
Carbohydrate Recognition
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Author : Binghe Wang
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-09
Carbohydrate Recognition written by Binghe Wang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-09 with Medical categories.
This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Carbohydrate Drug Design
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Author : Anatoliĭ Alekseevich Klesov
language : en
Publisher:
Release Date : 2006
Carbohydrate Drug Design written by Anatoliĭ Alekseevich Klesov and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
It is becoming more obvious in recent years that carbohydrates present a new dimension in drug design for targeting specific diseases. Carbohydrates birthed a whole new vocabulary into chemistry, biochemistry and related disciplines -- a new language in the form of distinct characters and images providing professional chemists not in the area of carbohydrates to become familiar and knowledgeable on the topic. Carbohydrate Drug Design provides the indispensable understanding of the mutual challenge between carbohydrate-based drugs and the deadly diseases which they target. Carbohydrate Drug Design discusses pre-clinical studies and clinical trials of carbohydrate-based drugs, drug delivery and pain managements, biocompatibility, clearance and metabolic pathways of carbohydrate drugs, and actual medical devices employing carbohydrates. The invasion of cancer cells, protein-glycan interactions and their inhibitors, new carbohydrate-based therapeutics, crystal structure of antibodies with unusually high affinity for carbohydrates, and a number of other features of carbohydrate drugs are also comprehensively covered. Galactomannans and hyaluronans, as well as thio-, imino- and carba-sugars are particularly considered in respect to their structural and functional impacts.