Carbonic Anhydrase Mechanism Regulation Links To Disease And Industrial Applications
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Carbonic Anhydrase Mechanism Regulation Links To Disease And Industrial Applications
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Author : Susan C. Frost
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-22
Carbonic Anhydrase Mechanism Regulation Links To Disease And Industrial Applications written by Susan C. Frost and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.
The Carbonic Anhydrases
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Author : W.R. Chegwidden
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-10
The Carbonic Anhydrases written by W.R. Chegwidden and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10 with Medical categories.
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...
Carbonic Anhydrases As Biocatalysts
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Author : Claudiu T. Supuran
language : en
Publisher: Elsevier
Release Date : 2015-01-14
Carbonic Anhydrases As Biocatalysts written by Claudiu T. Supuran and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-14 with Technology & Engineering categories.
Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications
Carbonic Anhydrase As Drug Target
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Author : Daumantas Matulis
language : en
Publisher: Springer
Release Date : 2019-05-21
Carbonic Anhydrase As Drug Target written by Daumantas Matulis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-21 with Science categories.
This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.
Cyanobacteria Biotechnology
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Author : Paul Hudson
language : en
Publisher: John Wiley & Sons
Release Date : 2021-04-20
Cyanobacteria Biotechnology written by Paul Hudson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-20 with Science categories.
Unites a biological and a biotechnological perspective on cyanobacteria, and includes the industrial aspects and applications of cyanobacteria Cyanobacteria Biotechnology offers a guide to the interesting and useful features of cyanobacteria metabolism that keeps true to a biotechnology vision. In one volume the book brings together both biology and biotechnology to illuminate the core acpects and principles of cyanobacteria metabolism. Designed to offer a practical approach to the metabolic engineering of cyanobacteria, the book contains relevant examples of how this metabolic "module" is currently being engineered and how it could be engineered in the future. The author includes information on the requirements and real-world experiences of the industrial applications of cyanobacteria. This important book: Brings together biology and biotechnology in order to gain insight into the industrial relevant topic of cyanobacteria Introduces the key aspects of the metabolism of cyanobacteria Presents a grounded, practical approach to the metabolic engineering of cyanobacteria Offers an analysis of the requirements and experiences for industrial cyanobacteria Provides a framework for readers to design their own processes Written for biotechnologists, microbiologists, biologists, biochemists, Cyanobacteria Biotechnology provides a systematic and clear volume that brings together the biological and biotechnological perspective on cyanobacteria.
Novel Materials For Carbon Dioxide Mitigation Technology
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Author : Bryan Morreale
language : en
Publisher: Elsevier
Release Date : 2015-06-01
Novel Materials For Carbon Dioxide Mitigation Technology written by Bryan Morreale and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-01 with Science categories.
Materials for Carbon Dioxide Mitigation Technology offers expert insight and experience from recognized authorities in advanced material development in carbon mitigation technology and constitutes a comprehensive guide to the selection and design of a wide range of solvent/sorbent/catalyst used by scientists globally. It appeals to chemical scientists, material scientists and engineers, energy researchers, and environmental scientists from academia, industry, and government in their research directed toward greener, more efficient carbon mitigation processes. Emphasizes material development for carbon mitigation technologies rather than regulations Provides a fundamental understanding of the underpinning science as well as technological approaches to implement carbon capture, utilization and storage technologies Introduces the driving force behind novel materials, their performance and applications for carbon dioxide mitigation Contains figures, tables and an abundance of examples clearly explaining the development, characterization and evaluation of novel carbon mitigation materials Includes hundreds of citations drawing on the most recent published works on the subject Provides a wealth of real-world examples, illustrating how to bridge nano-scale materials to bulk carbon mitigation properties
Mining Designing Mechanisms And Applications Of Extremophilic Enzymes
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Author : Junpei Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-29
Mining Designing Mechanisms And Applications Of Extremophilic Enzymes written by Junpei Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-29 with Science categories.
The Carbonic Anhydrases Current And Emerging Therapeutic Targets
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Author : W. Richard Chegwidden
language : en
Publisher: Springer Nature
Release Date : 2021-10-30
The Carbonic Anhydrases Current And Emerging Therapeutic Targets written by W. Richard Chegwidden and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-30 with Medical categories.
This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
Climate Change And Green Chemistry Of Co2 Sequestration
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Author : Malti Goel
language : en
Publisher: Springer Nature
Release Date : 2021-05-10
Climate Change And Green Chemistry Of Co2 Sequestration written by Malti Goel and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-10 with Business & Economics categories.
The book comprises state-of-the-art scientific reviews on carbon management strategies in response to climate change. It provides in-depth information on topics relating to recent advances in carbon capture technology and its reuse in value added products. It features contributions of leading scientists and technocrats on topics including climate change and carbon sequestration, lowering carbon footprint CO2 capture, low carbon imperatives in oil industry, CO2 as refrigerant in cold-chain application, carbonic anhydrase-mediated carbon sequestration and utilization, chemical looping combustion with Indian coal, CO2 conversion to chemicals, algae based biofuels, and carbon capture patent landscaping analysis. The contents of this book will be helpful for research scholars, post-graduate students, industry, agricultural scientists and policy makers/planners.
The Carbonic Anhydrases Current And Emerging Therapeutic Targets
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Author : W. Richard Chegwidden
language : en
Publisher:
Release Date : 2021
The Carbonic Anhydrases Current And Emerging Therapeutic Targets written by W. Richard Chegwidden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.