The Carbonic Anhydrases
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The Carbonic Anhydrases
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Author : W.R. Chegwidden
language : en
Publisher: Birkhäuser
Release Date : 2013-11-11
The Carbonic Anhydrases written by W.R. Chegwidden and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...
The Carbonic Anhydrases
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Author : N.D. Carter
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
The Carbonic Anhydrases written by N.D. Carter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant decrease in a 3 hydroxyl ion. Globally, the functions of the carbonic anhydrases in photosynthesis in rain forests and in the algae and plankton that cover our oceans indicate that they are also of utmost importance in the maintenance of the acid-base balance on our planet. Although the whole field of C0 metabolism is enormous and still rapidly 2 expanding, because of the research interests of the editors this book is mainly concerned with mammalian carbonic anhydrases. However, if the interested reader intends to purify carbonic anhydrases from nonmammalian sources, Dr. Cheg widden has provided the necessary information in Chapter 7. The carbonic anhydrases were first discovered in 1933; until1976 there were thought to be only two isozymes. Since then CA ill, IY, V, VI, and Vll have been discovered and well characterized. There is, of course, no reason to believe that we have found them all.
Carbonic Anhydrase Mechanism Regulation Links To Disease And Industrial Applications
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Author : Susan C. Frost
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-22
Carbonic Anhydrase Mechanism Regulation Links To Disease And Industrial Applications written by Susan C. Frost and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.
Carbonic Anhydrase As Drug Target
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Author : Daumantas Matulis
language : en
Publisher: Springer
Release Date : 2019-05-21
Carbonic Anhydrase As Drug Target written by Daumantas Matulis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-21 with Science categories.
This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also types and chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.
The Carbonic Anhydrases Current And Emerging Therapeutic Targets
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Author : W. Richard Chegwidden
language : en
Publisher:
Release Date : 2021
The Carbonic Anhydrases Current And Emerging Therapeutic Targets written by W. Richard Chegwidden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
Biology And Chemistry Of The Carbonic Anhydrases
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Author : Richard E. Tashian
language : en
Publisher:
Release Date : 1984
Biology And Chemistry Of The Carbonic Anhydrases written by Richard E. Tashian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with categories.
The Carbonic Anhydrases Current And Emerging Therapeutic Targets
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Author : W. Richard Chegwidden
language : en
Publisher: Springer Nature
Release Date : 2021-10-30
The Carbonic Anhydrases Current And Emerging Therapeutic Targets written by W. Richard Chegwidden and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-30 with Medical categories.
This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
Carbonic Anhydrase
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Author : Claudiu T. Supuran
language : en
Publisher: CRC Press
Release Date : 2004-05-27
Carbonic Anhydrase written by Claudiu T. Supuran and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-05-27 with Medical categories.
Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in
Carbonic Anhydrases As Biocatalysts
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Author : Claudiu T. Supuran
language : en
Publisher: Elsevier
Release Date : 2015-01-14
Carbonic Anhydrases As Biocatalysts written by Claudiu T. Supuran and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-14 with Technology & Engineering categories.
Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications
Carbonic Anhydrases
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Author : Joni Penttinen
language : en
Publisher:
Release Date : 2018
Carbonic Anhydrases written by Joni Penttinen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Biotechnology categories.
In this compilation, the authors address the relationship between carbonic anhydrase IX and hypoxia. Hypoxia is a key factor influencing a life-cycle of CA IX, including its expression, correct structure, stability, function, and subsequent biological implications. Hypoxia also regulates CA IX expression by post-transcriptional mechanisms through splicing and mRNA stabilization. A review is provided focusing on the sequence of elementary reactions ensuing a catalytic reaction (catalytic mechanism) of carbonic anhydrase. The closing chapter discusses carbonic anhydrases in chloroplasts, especially their location in the organelles, as well as considers their uses.