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Causal Inference In Pharmaceutical Statistics


Causal Inference In Pharmaceutical Statistics
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Causal Inference In Pharmaceutical Statistics


Causal Inference In Pharmaceutical Statistics
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Author : Yixin Fang
language : en
Publisher:
Release Date : 2024

Causal Inference In Pharmaceutical Statistics written by Yixin Fang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with Mathematics categories.


Causal Inference in Pharmaceutical Statistics introduces the basic concepts and fundamental methods of causal inference relevant to pharmaceutical statistics. This book covers causal thinking for different types of commonly used study designs in the pharmaceutical industry, including but not limited to randomized controlled clinical trials, longitudinal studies, singlearm clinical trials with external controls, and real-world evidence studies. The book starts with the central questions in drug development and licensing, takes the reader through the basic concepts and methods via different study types and through different stages, and concludes with a roadmap to conduct causal inference in clinical studies. The book is intended for clinical statisticians and epidemiologists working in the pharmaceutical industry. It will also be useful to graduate students in statistics, biostatistics, and data science looking to pursue a career in the pharmaceutical industry. Key Features: Causal inference book for clinical statisticians in the pharmaceutical industry Introductory level on the most important concepts and methods Align with FDA and ICH guidance documents Across different stages of clinical studies: plan, design, conduct, analysis, and interpretation Cover a variety of commonly used study designs



Causal Inference In Pharmaceutical Statistics


Causal Inference In Pharmaceutical Statistics
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Author : Yixin Fang (Statistician)
language : en
Publisher:
Release Date : 2024

Causal Inference In Pharmaceutical Statistics written by Yixin Fang (Statistician) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with Clinical trials categories.


"Causal Inference in Pharmaceutical Statistics introduces the basic concepts and fundamental methods of causal inference relevant to pharmaceutical statistics. This book covers causal thinking for different types of commonly used study designs in the pharmaceutical industry, including but not limited to randomized controlled clinical trials, longitudinal studies, single-arm clinical trials with external controls, and real-world evidence studies. The book starts with the central questions in drug development and licensing, takes the reader through the basic concepts and methods via different study types and through different stages, and conclude with a roadmap to conduct causal inference in clinical studies. The book is intended for clinical statisticians and epidemiologists working in the pharmaceutical industry. It will also be useful to graduate students in statistics, biostatistics, and data science looking to pursue a career in the pharmaceutical industry"--



Causal Inference In Pharmaceutical Statistics


Causal Inference In Pharmaceutical Statistics
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Author : Yixin Fang
language : en
Publisher: CRC Press
Release Date : 2024-06-24

Causal Inference In Pharmaceutical Statistics written by Yixin Fang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-24 with Mathematics categories.


Causal Inference in Pharmaceutical Statistics introduces the basic concepts and fundamental methods of causal inference relevant to pharmaceutical statistics. This book covers causal thinking for different types of commonly used study designs in the pharmaceutical industry, including but not limited to randomized controlled clinical trials, longitudinal studies, singlearm clinical trials with external controls, and real-world evidence studies. The book starts with the central questions in drug development and licensing, takes the reader through the basic concepts and methods via different study types and through different stages, and concludes with a roadmap to conduct causal inference in clinical studies. The book is intended for clinical statisticians and epidemiologists working in the pharmaceutical industry. It will also be useful to graduate students in statistics, biostatistics, and data science looking to pursue a career in the pharmaceutical industry. Key Features: Causal inference book for clinical statisticians in the pharmaceutical industry Introductory level on the most important concepts and methods Align with FDA and ICH guidance documents Across different stages of clinical studies: plan, design, conduct, analysis, and interpretation Cover a variety of commonly used study designs



Causal Inference In Statistics


Causal Inference In Statistics
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Author : Judea Pearl
language : en
Publisher: John Wiley & Sons
Release Date : 2016-01-25

Causal Inference In Statistics written by Judea Pearl and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-25 with Mathematics categories.


CAUSAL INFERENCE IN STATISTICS A Primer Causality is central to the understanding and use of data. Without an understanding of cause–effect relationships, we cannot use data to answer questions as basic as "Does this treatment harm or help patients?" But though hundreds of introductory texts are available on statistical methods of data analysis, until now, no beginner-level book has been written about the exploding arsenal of methods that can tease causal information from data. Causal Inference in Statistics fills that gap. Using simple examples and plain language, the book lays out how to define causal parameters; the assumptions necessary to estimate causal parameters in a variety of situations; how to express those assumptions mathematically; whether those assumptions have testable implications; how to predict the effects of interventions; and how to reason counterfactually. These are the foundational tools that any student of statistics needs to acquire in order to use statistical methods to answer causal questions of interest. This book is accessible to anyone with an interest in interpreting data, from undergraduates, professors, researchers, or to the interested layperson. Examples are drawn from a wide variety of fields, including medicine, public policy, and law; a brief introduction to probability and statistics is provided for the uninitiated; and each chapter comes with study questions to reinforce the readers understanding.



Handbook Of Matching And Weighting Adjustments For Causal Inference


Handbook Of Matching And Weighting Adjustments For Causal Inference
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Author : José R. Zubizarreta
language : en
Publisher: CRC Press
Release Date : 2023-04-11

Handbook Of Matching And Weighting Adjustments For Causal Inference written by José R. Zubizarreta and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-11 with Mathematics categories.


An observational study infers the effects caused by a treatment, policy, program, intervention, or exposure in a context in which randomized experimentation is unethical or impractical. One task in an observational study is to adjust for visible pretreatment differences between the treated and control groups. Multivariate matching and weighting are two modern forms of adjustment. This handbook provides a comprehensive survey of the most recent methods of adjustment by matching, weighting, machine learning and their combinations. Three additional chapters introduce the steps from association to causation that follow after adjustments are complete. When used alone, matching and weighting do not use outcome information, so they are part of the design of an observational study. When used in conjunction with models for the outcome, matching and weighting may enhance the robustness of model-based adjustments. The book is for researchers in medicine, economics, public health, psychology, epidemiology, public program evaluation, and statistics who examine evidence of the effects on human beings of treatments, policies or exposures.



Elements Of Causal Inference


Elements Of Causal Inference
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Author : Jonas Peters
language : en
Publisher: MIT Press
Release Date : 2017-11-29

Elements Of Causal Inference written by Jonas Peters and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-29 with Computers categories.


A concise and self-contained introduction to causal inference, increasingly important in data science and machine learning. The mathematization of causality is a relatively recent development, and has become increasingly important in data science and machine learning. This book offers a self-contained and concise introduction to causal models and how to learn them from data. After explaining the need for causal models and discussing some of the principles underlying causal inference, the book teaches readers how to use causal models: how to compute intervention distributions, how to infer causal models from observational and interventional data, and how causal ideas could be exploited for classical machine learning problems. All of these topics are discussed first in terms of two variables and then in the more general multivariate case. The bivariate case turns out to be a particularly hard problem for causal learning because there are no conditional independences as used by classical methods for solving multivariate cases. The authors consider analyzing statistical asymmetries between cause and effect to be highly instructive, and they report on their decade of intensive research into this problem. The book is accessible to readers with a background in machine learning or statistics, and can be used in graduate courses or as a reference for researchers. The text includes code snippets that can be copied and pasted, exercises, and an appendix with a summary of the most important technical concepts.



Causality


Causality
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Author : Judea Pearl
language : en
Publisher: Cambridge University Press
Release Date : 2009-09-14

Causality written by Judea Pearl and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-14 with Computers categories.


Causality offers the first comprehensive coverage of causal analysis in many sciences, including recent advances using graphical methods. Pearl presents a unified account of the probabilistic, manipulative, counterfactual and structural approaches to causation, and devises simple mathematical tools for analyzing the relationships between causal connections, statistical associations, actions and observations. The book will open the way for including causal analysis in the standard curriculum of statistics, artificial intelligence ...



Real World Evidence In Medical Product Development


Real World Evidence In Medical Product Development
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Author : Weili He
language : en
Publisher: Springer Nature
Release Date : 2023-05-11

Real World Evidence In Medical Product Development written by Weili He and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-11 with Mathematics categories.


This book provides state-of-art statistical methodologies, practical considerations from regulators and sponsors, logistics, and real use cases for practitioners for the uptake of RWE/D. Randomized clinical trials have been the gold standard for the evaluation of efficacy and safety of medical products. However, the cost, duration, practicality, and limited generalizability have incentivized many to look for alternative ways to optimize drug development. This book provides a comprehensive list of topics together to include all aspects with the uptake of RWE/D, including, but not limited to, applications in regulatory and non-regulatory settings, causal inference methodologies, organization and infrastructure considerations, logistic challenges, and practical use cases.



Applied Microbiome Statistics


Applied Microbiome Statistics
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Author : Yinglin Xia
language : en
Publisher: CRC Press
Release Date : 2024-07-22

Applied Microbiome Statistics written by Yinglin Xia and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-22 with Mathematics categories.


This unique book officially defines microbiome statistics as a specific new field of statistics and addresses the statistical analysis of correlation, association, interaction, and composition in microbiome research. It also defines the study of the microbiome as a hypothesis-driven experimental science and describes two microbiome research themes and six unique characteristics of microbiome data, as well as investigating challenges for statistical analysis of microbiome data using the standard statistical methods. This book is useful for researchers of biostatistics, ecology, and data analysts. Presents a thorough overview of statistical methods in microbiome statistics of parametric and nonparametric correlation, association, interaction, and composition adopted from classical statistics and ecology and specifically designed for microbiome research. Performs step-by-step statistical analysis of correlation, association, interaction, and composition in microbiome data. Discusses the issues of statistical analysis of microbiome data: high dimensionality, compositionality, sparsity, overdispersion, zero-inflation, and heterogeneity. Investigates statistical methods on multiple comparisons and multiple hypothesis testing and applications to microbiome data. Introduces a series of exploratory tools to visualize composition and correlation of microbial taxa by barplot, heatmap, and correlation plot. Employs the Kruskal–Wallis rank-sum test to perform model selection for further multi-omics data integration. Offers R code and the datasets from the authors’ real microbiome research and publicly available data for the analysis used. Remarks on the advantages and disadvantages of each of the methods used.



Uncertainty In Pharmacology


Uncertainty In Pharmacology
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Author : Adam LaCaze
language : en
Publisher: Springer Nature
Release Date : 2020-02-20

Uncertainty In Pharmacology written by Adam LaCaze and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-20 with Medical categories.


This volume covers a wide range of topics concerning methodological, epistemological, and regulatory-ethical issues around pharmacology. The book focuses in particular on the diverse sources of uncertainty, the different kinds of uncertainty that there are, and the diverse ways in which these uncertainties are (or could be) addressed. Compared with the more basic sciences, such as chemistry or biology, pharmacology works across diverse observable levels of reality: although the first step in the causal chain leading to the therapeutic outcome takes place at the biochemical level, the end-effect is a clinically observable result—which is influenced not only by biological actions, but also psychological and social phenomena. Issues of causality and evidence must be treated with these specific aspects in mind. In covering these issues, the book opens up a common domain of investigation which intersects the deeply intertwined dimensions of pharmacological research, pharmaceutical regulation and the related economic environment. The book is a collective endeavour with in-depth contributions from experts in pharmacology, philosophy of medicine, statistics, scientific methodology, formal and social epistemology, working in constant dialogue across disciplinary boundaries.