Cd4 Cd25 Regulatory T Cells Origin Function And Therapeutic Potential
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Cd4 Cd25 Regulatory T Cells Origin Function And Therapeutic Potential
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Author : B. Kyewski
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-09
Cd4 Cd25 Regulatory T Cells Origin Function And Therapeutic Potential written by B. Kyewski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-09 with Medical categories.
The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
Signaling Mechanisms Regulating T Cell Diversity And Function
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Author : Jonathan Soboloff
language : en
Publisher: CRC Press
Release Date : 2017-03-27
Signaling Mechanisms Regulating T Cell Diversity And Function written by Jonathan Soboloff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-27 with Medical categories.
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Therapeutic Potential Of Gene Modified Regulatory T Cells
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Author : Jelena Skuljec
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-20
Therapeutic Potential Of Gene Modified Regulatory T Cells written by Jelena Skuljec and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-20 with Medical categories.
The Therapeutic Potential Of Antigen Presenting Cells
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Author : Georgina Clark
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-16
The Therapeutic Potential Of Antigen Presenting Cells written by Georgina Clark and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-16 with Medical categories.
Gene Therapy Of Autoimmune Disease
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Author : Gerald J. Prud'homme
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-26
Gene Therapy Of Autoimmune Disease written by Gerald J. Prud'homme and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-26 with Medical categories.
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
New Insights Into Thymic Functions During Stress Aging And In Disease Settings
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Author : Nicolai Stanislas van Oers
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-23
New Insights Into Thymic Functions During Stress Aging And In Disease Settings written by Nicolai Stanislas van Oers and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-23 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Melanoma
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Author : Sanjiv S. Agarwala
language : en
Publisher: CRC Press
Release Date : 2008-08-08
Melanoma written by Sanjiv S. Agarwala and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-08 with Medical categories.
Assembling, reviewing, and synthesizing state-of-the-art information on translational research and therapies of melanoma into one convenient source, Melanoma: Translational Research and Emerging Therapies provides clinicians and researchers the necessary context and perspective to intergrate and effectively deploy cutting-edge therapies into daily
The Autoimmune Diseases
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Author : M. Eric Gershwin
language : en
Publisher: Elsevier
Release Date : 2006-05-15
The Autoimmune Diseases written by M. Eric Gershwin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-15 with Medical categories.
Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.New to This Edition:* Tissue-specific interventions to arrest or "cure" autoimmune disease* Bone marrow eradication and replacement* Both basic science and clinical medicine is covered* Boxed points to emphasize key features of each chapter
Characterization Functions And Roles Of Antigen Specific Regulatory T Cells In Health And Disease
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Author : Giang Tran
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-09
Characterization Functions And Roles Of Antigen Specific Regulatory T Cells In Health And Disease written by Giang Tran and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-09 with Medical categories.
Innate Immune Regulation And Cancer Immunotherapy
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Author : Rong-Fu Wang
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-02
Innate Immune Regulation And Cancer Immunotherapy written by Rong-Fu Wang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-02 with Medical categories.
Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.