Cell Cycle Checkpoints
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Cell Cycle Checkpoint Control Protocols
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Author : Howard B. Lieberman
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Cell Cycle Checkpoint Control Protocols written by Howard B. Lieberman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
The field of cell cycle regulation is based on the observation that the life cycle of a cell progresses through several distinct phases, G1, M, S, and G2, occurring in a well-defined temporal order. Details of the mechanisms involved are rapidly emerging and appear extraordinarily complex. Furthermore, not only is the order of the phases important, but in normal eukaryotic cells one phase will not begin unless the prior phase is completed successfully. Che- point control mechanisms are essentially surveillance systems that monitor the events in each phase, and assure that the cell does not progress prematurely to the next phase. If conditions are such that the cell is not ready to progress—for example, because of incomplete DNA replication in S or DNA damage that may interfere with chromosome segregation in M—a transient delay in cell cycle progression will occur. Once the inducing event is properly handled— for example, DNA replication is no longer blocked or damaged DNA is repaired—cell cycle progression continues. Checkpoint controls have recently been the focus of intense study by investigators interested in mechanisms that regulate the cell cycle. Furthermore, the relationship between checkpoint c- trol and carcinogenesis has additionally enhanced interest in these cell cycle regulatory pathways. It is clear that cancer cells often lack these checkpoints and exhibit genomic instability as a result. Moreover, several tumor suppressor genes participate in checkpoint control, and alterations in these genes are as- ciated with genomic instability as well as the development of cancer.
Cell Cycle Checkpoints
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Author : Willis X. Li
language : en
Publisher: Humana Press
Release Date : 2011-08-31
Cell Cycle Checkpoints written by Willis X. Li and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-31 with Science categories.
Cell cycle checkpoints control the fidelity and orderly progression of eukaryotic cell division. By controlling the orderly progression of critical cell cycle events such as DNA replication and chromosome segregation and ensuring proper repair of damaged DNA, cell cycle checkpoints function to ensure genome integrity. Mechanisms of checkpoint controls are not only the research focus of investigators interested in mechanisms that regulate the cell cycle, but are also the interests of researchers studying cancer development as it is increasingly clear that loss of cell cycle checkpoints, which leads to genomic instability as a result, is a hallmark of tumorigenesis. Cell Cycle Checkpoints: Methods and Protocols provides detailed descriptions of methodologies currently employed by researchers in the field, including those commonly used in the mammalian, yeast, C. elegans, Drosophila, and Xenopus model systems. Each chapter describes a specific technique or protocol, such as a method to induce cell cycle checkpoints in a particular model system, to synchronize a population of cells to allow observations of cell cycle progression, to identify genes involved in checkpoint regulation, and to study particular protein components of cell cycle checkpoint pathways. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cell Cycle Checkpoints: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further our knowledge of this essential field.
Cell Cycle Regulation And Differentiation In Cardiovascular And Neural Systems
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Author : Antonio Giordano
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-08-17
Cell Cycle Regulation And Differentiation In Cardiovascular And Neural Systems written by Antonio Giordano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-17 with Medical categories.
Complex physiopathological relationships have been proven to exist between two of the body’s most vital organs; the brain and the heart. In Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems Antonio Giordano, Umberto Galderisi and a panel of the most respected authorities in their field offer an in-depth analysis of the differentiation process in two systems that have profound relationships with one another. The text looks at several aspects of the cardiovascular and nervous systems from a new point of view, describing the differences and similarities in their differentiation pathways with an emphasis on the role of cell cycle regulation and cell differentiation. Topics discussed include neurogenesis in the central nervous system, neural stem cells, and the basic-helix-loop-helix transcription factors in neural differentiation. Ground-breaking and authoritative, Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems is a must have for all researchers in cardiovascular medicine and neuroscience and will prompt the scientific community to perceive cell cycle regulation and differentiation under a novel and more comprehensive light.
Checkpoint Controls And Cancer
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Author : Axel H. Schönthal
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Checkpoint Controls And Cancer written by Axel H. Schönthal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Medical categories.
Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired. Moreover, internal errors can occur during the highly orchestrated replication of the cellular genome and its distribution into daughter cells. Here, the temporal order of these cell cycle events must be strictly enforced—for example, to ensure that DNA replication is c- plete and occurs only once before cell division, or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maintenance of genomic integrity and the basic viability of cells and, the- fore, are essential for proper development and survival. The importance of proper functioning of checkpoints becomes plainly obvious under conditions in which this control network malfunctions and fails. Depending on the severity and timing, failure of this machinery can lead to embryonic lethality, genetic diseases, and cancer.
The Cell Cycle
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Author : David Owen Morgan
language : en
Publisher: New Science Press
Release Date : 2007
The Cell Cycle written by David Owen Morgan and has been published by New Science Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Science categories.
Cell division is a central biological process: it yields the cells required for development and growth, and supplies the replacement cells to repair and maintain old or damaged tissue. This book gives the students a complete overview of the process of cell division - from chromosome division, through mitosis, cytokinesis, and meiosis.
Dynamics Of Cell Division
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Author : Sharyn A. Endow
language : en
Publisher: OUP Oxford
Release Date : 1998-10-01
Dynamics Of Cell Division written by Sharyn A. Endow and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-10-01 with Science categories.
This volume focuses on the structural aspects of cell division - concentrating on both nuclear division (meiosis and mitosis) and cytoplasmic division (cytokinesis). Written as a companion volume to the earlier book in the series - Cell Cycle Control, this book provides an up-to-date account of developments in this exciting area of cell biology.
Cell Cycle Synchronization
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Author : Zhixiang Wang
language : en
Publisher: Springer Nature
Release Date : 2022-08-31
Cell Cycle Synchronization written by Zhixiang Wang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-31 with Science categories.
This volume covers a broad range of cell types including cultured cell lines, primary cells, and various unicellular organisms such as fission yeast, budding yeast, parasite Leishmania amazonensis, and parasite Trypanosoma brucei. The chapters in this book are organized into four parts. Part One looks at a general overview of cell cycle control and synchronization. Part Two discusses techniques to synchronize mammalian cells to various cell cycle phases including mitotic sub-phases. Part Three covers synchronization of unicellular organisms and Part Four analyzes cell cycle progression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Cell-Cycle Synchronization: Methods and Protocols is a valuable resource for both novice and expert scientists in this developing field.
Cell Cycle Checkpoints And Cancer
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Author : Mikhail V. Blagosklonny
language : en
Publisher:
Release Date : 2001
Cell Cycle Checkpoints And Cancer written by Mikhail V. Blagosklonny and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Control Of Cell Cycle And Cell Proliferation
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Author : Rossen Donev
language : en
Publisher: Elsevier
Release Date : 2023-04-13
Control Of Cell Cycle And Cell Proliferation written by Rossen Donev and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-13 with Science categories.
Control of Cell Cycle and Cell Proliferation, Volume 135 in the Advances in Protein Chemistry and Structural Biology series, presents chapters on a variety topics, including Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest, Viral infection on through Cell Cycle Regulation, Analyzing drug resistant mutation in CDK4 gene and identification of potential inhibitors through structure based virtual screening approach, Controlling cell proliferation by targeting CDK6 using drug repurposing approach, The role of the nucleolus in regulating cell cycle, Chromatin regulators in DNA replication and genome stability maintenance during S-phase, Role of macrophage in cancer cell progression and targeted immunotherapies, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Protein Chemistry and Structural Biology series - Includes the latest information on Control of Cell Cycle and Cell Proliferation
Cell Cycle Control
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Author : Anna Castro
language : en
Publisher: Springer Nature
Release Date : 2024-02-23
Cell Cycle Control written by Anna Castro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-23 with Science categories.
This detailed volume collects techniques to study the highly regulated cell cycle process. Beginning with chapters investigating these processes and assessing how cells respond when these complicated pathways are simplified by using synthetic biology and in vitro reconstitutions, the book continues by exploring how cells sense and respond to environmental conditions, different model systems and cellular types used to visualize cellular architecture during cell division, as well as innovative single cell microscopy techniques to highlight the heterogeneity of the cell population with respect to cell cycle progression. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cell Cycle Control: Methods and Protocols serves as an ideal guide for researchers attempting to elucidate this vital area of cell biology.