Cell Death Inflammation And Oxidative Stress In Neurodegenerative Diseases
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Cell Death Inflammation And Oxidative Stress In Neurodegenerative Diseases
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Author : Anne Vejux
language : en
Publisher: Mdpi AG
Release Date : 2022-01-17
Cell Death Inflammation And Oxidative Stress In Neurodegenerative Diseases written by Anne Vejux and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-17 with Science categories.
Neurogenerative diseases encompass very different pathologies, which can be demyelinating or nondemyelinating, but which have common mechanisms such as cell death, oxidative stress and inflammation. A better understanding of these mechanisms allows the search for biomarkers and targets for new therapies. This special issue brings together different data on Alzheimer's disease, Parkinson's disease, and multiple sclerosis, detailing the mechanisms of cell death (necroptosis, ferroptosis), oxidative stress and inflammation but also the possibilities of neuroprotection via 5 research articles and 6 review articles. The different reviews allow us to take stock of cell death, oxidative stress and neuroinflammation in the context of neurodegenerative diseases but also in relation to other pathologies where these processes are involved.
Oxidative Stress Inflammation And Health
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Author : Young-Joon Surh
language : en
Publisher: CRC Press
Release Date : 2005-05-24
Oxidative Stress Inflammation And Health written by Young-Joon Surh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-24 with Science categories.
Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.
Inflammation And Oxidative Stress In Neurological Disorders
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Author : Akhlaq A. Farooqui
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-01-27
Inflammation And Oxidative Stress In Neurological Disorders written by Akhlaq A. Farooqui and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-27 with Medical categories.
Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.
Inflammation Aging And Oxidative Stress
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Author : Stephen C. Bondy
language : en
Publisher: Springer
Release Date : 2016-12-14
Inflammation Aging And Oxidative Stress written by Stephen C. Bondy and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-14 with Science categories.
The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.
The Role Of Oxidative Stress In Neuronal Death
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Author : Irene Ceballos-Picot
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
The Role Of Oxidative Stress In Neuronal Death written by Irene Ceballos-Picot and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
This book examines current knowledge and recent advances in the study of fundamental processes involved in neuronal death, particularly oxidative stress as a causal agent or risk factor. The author presents discussion of oxidative stress in neuronal apoptosis and its role in the neuropathogenesis of age-related neurodegenerative diseases exemplified by Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis.
The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases
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Author : Ramkumar Mathur
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-25
The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases written by Ramkumar Mathur and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-25 with Science categories.
Age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuroinflammation as well as neuronal degeneration. Apoptosis, necrosis, and autophagy are all types of programmed cell death that are morphologically distinct from one another. Over the last decade, extensive research has been conducted on necroptosis, resulting in a better understanding of its molecular underpinnings and role in neurodegenerative diseases. A later study investigates the processes of apoptosis and necroptosis, as well as their roles in the activation of inflammatory immune responses. Although there is a distinct mode of cell death with distinct morphological characteristics, its identification and implications in neurological diseases are still unknown. Interestingly, emerging evidence has established a direct link between epigenetic and posttranslational modifications and neurodegenerative disease. Using epigenetic and proteomic methods, researchers uncovered genes and proteins that may play a function in the area of neuroinflammation, a role that has hitherto been overlooked. New pharmacological targets and therapeutic options for neurodegenerative diseases are being investigated in order to gain a better understanding of the disease's origins and progression by using neuronal death and neuroinflammation models that are associated with epigenetic changes.
Oxidative Stress And Age Related Neurodegeneration
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Author : Yuan Luo
language : en
Publisher: CRC Press
Release Date : 2005-11-21
Oxidative Stress And Age Related Neurodegeneration written by Yuan Luo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-21 with Science categories.
Despite the progress being made by researchers, Alzheimer’s disease, along with other age-related neurodegenerative disorders, continues to exact a tremendous toll on our society. However, we are beginning to see a relationship that ties degenerative disorders to oxidative stress and lifestyle, suggesting the possibility for prevention and intervention through changes of individual habits, especially with regard to diet. Oxidative Stress and Age-Related Neurodegeneration brings together expert researchers involved with recent developments across a variety of fields. In looking at causation, prevention, and therapy, they offer contributions addressing these questions: What similarities and differences exist between normal aging and disease-related neurodegeneration in terms of susceptibility to and effects of oxidative stress? How can oxidative stress or its effects be attenuated? Do antioxidants prevent or slow the progress of the disease? Is there any role for natural micronutrients in the attenuation of oxidative stress and prevention of age-related neurodegeneration? Some chapters look at the various ways research is getting to the core of neurodegenerative disease, including the use of proteomics, comparisons to related diseases, and examinations at the cellular and molecular levels. Other chapters focus on specific antioxidants and nutrients cited as being impactful, such as those found in Gingko biloba, green tea, blueberries, and grape seed extract. Researchers in academia, industry, and clinical medicine, as well as students and scholars will find use for this timely collection, either as an introduction to our current understanding of neurodegeneration or as a reference for further research. Clinicians will also benefit, as this book explains the basis for many of the latest approaches to prevention and therapy.
Involvements Of Trp Channels Oxidative Stress And Apoptosis In Neurodegenerative Diseases
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Author : Mustafa Naziroglu
language : en
Publisher: Frontiers Media SA
Release Date : 2021-05-03
Involvements Of Trp Channels Oxidative Stress And Apoptosis In Neurodegenerative Diseases written by Mustafa Naziroglu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-03 with Science categories.
Antioxidants And Functional Foods For Neurodegenerative Disorders
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Author : Abhai Kumar
language : en
Publisher: CRC Press
Release Date : 2021-01-07
Antioxidants And Functional Foods For Neurodegenerative Disorders written by Abhai Kumar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-07 with Health & Fitness categories.
Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants – including vitamin D, tocotrienol and coenzyme Q10 – against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases.
Neuro Inflammation In Neuronal Death And Repair
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Author :
language : en
Publisher: Elsevier
Release Date : 2007-07-25
Neuro Inflammation In Neuronal Death And Repair written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-25 with Science categories.
Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their role in the degradation of extracellular macromolecules, MMPs could work as important signalling molecules from injured neurons to the microglia. Thus, MMP-3 has been shown to induce the release of pro-inflammatory cytokines from microglia via activation of ERK and NF-kB-dependent pathways. Increasing evidence highlights the importance of a balanced cross-talk between neurons and non-neuronal cells and indicates that the presence of reactive astrocytes, the activation of microglia and the release of inflammatory mediators may contribute to the progression of many central nervous system disorders, independently of the nature of the primary pathogenic event. However, many aspects still remain controversial and much more effort is needed to understand the role of neuroinflammatory mediators and processes in these conditions. This volume brings together renowned, international scientists to discuss current knowledge and views on the mechanisms of neuroinflammation, on its role in the context of different neurodegenerative diseases (i.e. Alzheimer's, prion disease, HIV-associated dementia, multiple sclerosis, pain) and on the potential approaches for future therapeutic strategies.