The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases
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The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases
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Author : Ramkumar Mathur
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-25
The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases written by Ramkumar Mathur and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-25 with Science categories.
Age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuroinflammation as well as neuronal degeneration. Apoptosis, necrosis, and autophagy are all types of programmed cell death that are morphologically distinct from one another. Over the last decade, extensive research has been conducted on necroptosis, resulting in a better understanding of its molecular underpinnings and role in neurodegenerative diseases. A later study investigates the processes of apoptosis and necroptosis, as well as their roles in the activation of inflammatory immune responses. Although there is a distinct mode of cell death with distinct morphological characteristics, its identification and implications in neurological diseases are still unknown. Interestingly, emerging evidence has established a direct link between epigenetic and posttranslational modifications and neurodegenerative disease. Using epigenetic and proteomic methods, researchers uncovered genes and proteins that may play a function in the area of neuroinflammation, a role that has hitherto been overlooked. New pharmacological targets and therapeutic options for neurodegenerative diseases are being investigated in order to gain a better understanding of the disease's origins and progression by using neuronal death and neuroinflammation models that are associated with epigenetic changes.
Hormones Regulators And Hippocampus
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Author : Gerald Litwack
language : en
Publisher: Academic Press
Release Date : 2022-02-16
Hormones Regulators And Hippocampus written by Gerald Litwack and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-16 with Science categories.
Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, including Thyroid hormone regulation of adult hippocampal neurogenesis – putative molecular and cellular mechanisms, Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus, Oxytocin and vasopressin in the hippocampus, Steroid hormones and hippocampal neurogenesis in the adult mammalian brain, Steroidogenic enzymes in the hippocampus: transcriptional regulation aspects, Ectonucleotidases in the hippocampus: spatial distribution and expression after ovariectomy and estradiol replacement, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Vitamins and Hormones serials - Updated release includes the latest information on Hormones, Regulators and Hippocampus
Molecular Basis Of Nutrition And Aging
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Author : Marco Malavolta
language : en
Publisher: Academic Press
Release Date : 2016-04-15
Molecular Basis Of Nutrition And Aging written by Marco Malavolta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-15 with Science categories.
Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. - Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging - Explores how nutritional factors are involved in the pathogenesis of aging across body systems - Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition
Reactive Oxygen Species
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2022-04-28
Reactive Oxygen Species written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-28 with Science categories.
The term “reactive oxygen species” (ROS) refers to a group of reactive molecules and free radicals produced by molecular oxygen. In recent decades, there has been great interest in the role of ROS in various diseases. From basic science research to clinical trials, biomedical scientists have made rapid progress toward a better understanding of ROS-metabolizing systems and their role in health and diseases. This book includes sixteen chapters that address topics such as the history of ROS, its role in autoimmunity, neurodegeneration, and aging, and recent advances in various antioxidants and their therapeutic potential.
Applied Pharmaceutical Science And Microbiology
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Author : Debarshi Kar Mahapatra
language : en
Publisher: CRC Press
Release Date : 2020-12-16
Applied Pharmaceutical Science And Microbiology written by Debarshi Kar Mahapatra and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-16 with Architecture categories.
This volume on applied pharmaceutical science and microbiology looks at the latest research on the applications of natural products for drug uses. It focuses on understanding how to apply the principles of novel green chemistry methods in the vital area of pharmaceuticals and covers the important aspects of green microbial technology in the pharmaceutical industry. Chapters include studies on the applications of natural products used in folk and regional medicines, such as for digestive problems, dermatological infections, respiratory diseases, vessel diseases, diarrhea and dysentery, ringworms, boils, fevers (antipyretic), skin and blood diseases, mouth sores, channel discharges, and even cancer. The volume also looks at medical benefit of microbial fermentation for the conservation of nutrients.
Flavonoids And Anti Aging
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Author : Karam F.A. Soliman
language : en
Publisher: CRC Press
Release Date : 2023-05-03
Flavonoids And Anti Aging written by Karam F.A. Soliman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-03 with Medical categories.
The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases. Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas. Key Features: Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals Presents flavonoid-based functional foods Discusses the flavonoid nutraceuticals market and future trends Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.
The Molecular Immunology Of Neurological Diseases
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Author : Sunil Kumar
language : en
Publisher: Academic Press
Release Date : 2021-02-16
The Molecular Immunology Of Neurological Diseases written by Sunil Kumar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-16 with Medical categories.
The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders. This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches. Discusses the molecular immunogenetics of different neurological diseases Covers strategies for the development of therapeutic approaches Encompasses both acute and chronic neurogenerative disorders Describes the molecular pathogenesis of viral genes in various diseases Features chapters on migraine, muscular dystrophy and cancer
Advances In Diagnostics And Immunotherapeutics For Neurodegenerative Diseases
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Author : Anuradha Mishra
language : en
Publisher: Bentham Science Publishers
Release Date : 2024-07-30
Advances In Diagnostics And Immunotherapeutics For Neurodegenerative Diseases written by Anuradha Mishra and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-30 with Medical categories.
Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases delves into the intricate mechanisms underlying neurodegenerative disorders and highlights cutting-edge diagnostic methods and innovative immunotherapeutic strategies. This comprehensive book addresses several key themes crucial to understanding and combating these debilitating conditions with an updated understanding of neurodegenerative disorders and a review of the latest advancements in diagnostic and treatment strategies. Key Themes Neuroinflammation: examines the complex molecular pathways involved in neuroinflammatory responses and their impact on disease dynamics. Gut-Brain Axis: A thorough discussion on the relationship between the gut microbiome and neurodegenerative processes is presented. Advanced Diagnostics: A state-of-the-art review of diagnostic techniques provides updates on advanced neuroimaging modalities, cerebrospinal fluid biomarker analysis, and genetic testing. Epigenetic Regulation of Microglia: Covers the emerging field of epigenetic modifications and their role in modulating microglial activation and function. Immunotherapeutics: Learn about the potential of monoclonal antibodies, immune modulators, and repurposed drug therapies in slowing disease progression and improving patient outcomes. This book serves as a valuable resource for researchers, clinicians, and students in the fields of molecular biology, neuroimmunology, and clinical neurology.
Neurobiological Underpinnings Of Neurodegenerative And Neuropsychiatric Disorders From Models To Therapy
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Author : Ferdinando Di Cunto
language : en
Publisher: Frontiers Media SA
Release Date : 2025-07-29
Neurobiological Underpinnings Of Neurodegenerative And Neuropsychiatric Disorders From Models To Therapy written by Ferdinando Di Cunto and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-29 with Science categories.
During the last two decades, advances in different areas of Neurosciences have clearly highlighted the complex nature of neuropsychiatric and neurodegenerative disorders. The proper assembly, maturation and maintenance of neuronal circuits underlying normal functioning of the nervous system require the execution of specific genetic programs, finely tuned in space and time. The widespread detection of genes, mRNA, proteins, and metabolites has shed much light on relevant missteps in these delicate processes that may cause detrimental consequences for brain wiring and function. A clear role of cell-autonomous alterations, involving cell adhesion molecules, ion channels and intracellular pathways impinging on synaptic function is well established in neuropsychiatric diseases. Similarly, modifications in protein sequence and structure resulting in the accumulation of insoluble aggregates are widely acknowledged as culprits of most neurodegenerative disorders. On the other hand, the careful study of pathophysiological mechanisms that may translate genetic predisposition into full manifested disease phenotypes has revealed the involvement of non-genetic and non-neuronal factors in establishment and propagation of the damage from cell to network level. Indeed, current research is emphasizing the crucial role of epigenetic modifications, metabolic rewiring, brain-immune system cross-talk, glial cell functions, gut-to-brain axis, and blood-brain barrier, both in neuropsychiatric and neurodegenerative disorders. Importantly, these additional layers of complexity represent a rich interface between genetic variants and environmental stressors, whose nature and relevance are also being elucidated.
Mechanism And Pharmacodynamic Material Basis Of Neurodegenerative Disease Therapies
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Author : Zhi Sun
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-25
Mechanism And Pharmacodynamic Material Basis Of Neurodegenerative Disease Therapies written by Zhi Sun and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-25 with Medical categories.
Neurodegenerative diseases are debilitating disorders defined as loss of function or progressive destructing structure of the nervous system with high prevalence among the aging population. These diseases mainly include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). They are significantly associated with age and degeneration, becoming a devastating global health issue as a result of the growth of mean life expectancy worldwide. Few or no effective treatments are available for age-related neurodegenerative diseases, causing large socioeconomic and personal costs. The last 15 years have seen a boom in the use and integration of “omic” approaches (such as genomic, transcriptomic, epigenomic and metabolomic techniques) to study neurodegenerative disease in an unprecedented way. While, to date, no therapy based on these approaches is available to cure neurodegenerative diseases. Therefore, it is necessary to search for new, safe, and effective drug candidates and treatment strategies. In this Research Topic, our prime focus would be on the use and integration of “omic” approaches to study biomarkers, pathogenesis, disease progression and new therapeutic target of neurodegenerative diseases, so as to search for new, safe, and effective drug candidates.