The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases
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The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases
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Author : Ramkumar Mathur
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-25
The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases written by Ramkumar Mathur and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-25 with Science categories.
Age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuroinflammation as well as neuronal degeneration. Apoptosis, necrosis, and autophagy are all types of programmed cell death that are morphologically distinct from one another. Over the last decade, extensive research has been conducted on necroptosis, resulting in a better understanding of its molecular underpinnings and role in neurodegenerative diseases. A later study investigates the processes of apoptosis and necroptosis, as well as their roles in the activation of inflammatory immune responses. Although there is a distinct mode of cell death with distinct morphological characteristics, its identification and implications in neurological diseases are still unknown. Interestingly, emerging evidence has established a direct link between epigenetic and posttranslational modifications and neurodegenerative disease. Using epigenetic and proteomic methods, researchers uncovered genes and proteins that may play a function in the area of neuroinflammation, a role that has hitherto been overlooked. New pharmacological targets and therapeutic options for neurodegenerative diseases are being investigated in order to gain a better understanding of the disease's origins and progression by using neuronal death and neuroinflammation models that are associated with epigenetic changes.
Neuroinflammation From Bench To Bedside
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Author : H. Kettenmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-05-15
Neuroinflammation From Bench To Bedside written by H. Kettenmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-15 with Medical categories.
This book deals with the subject of neuroinflammation and attempts to take the reader on a journey from the bench to the bedside. The microglia and their response to brain injury as well as the importance of the chemokine family are discussed. The relevance of neuroinflammation in experimental models of BSE, scrapie and vCJD as well as Alzheimer's disease, stroke and multiple sclerosis is investigated before proceeding to clinical aspects of neuroinflammation and its involvement in human disease pathophysiology. The book provides an excellent introduction to the field of neuroinflammation and its involvement in human neurodegenerative disease.
Cell Death Inflammation And Oxidative Stress In Neurodegenerative Diseases
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Author : Anne Vejux
language : en
Publisher: Mdpi AG
Release Date : 2022-01-17
Cell Death Inflammation And Oxidative Stress In Neurodegenerative Diseases written by Anne Vejux and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-17 with Science categories.
Neurogenerative diseases encompass very different pathologies, which can be demyelinating or nondemyelinating, but which have common mechanisms such as cell death, oxidative stress and inflammation. A better understanding of these mechanisms allows the search for biomarkers and targets for new therapies. This special issue brings together different data on Alzheimer's disease, Parkinson's disease, and multiple sclerosis, detailing the mechanisms of cell death (necroptosis, ferroptosis), oxidative stress and inflammation but also the possibilities of neuroprotection via 5 research articles and 6 review articles. The different reviews allow us to take stock of cell death, oxidative stress and neuroinflammation in the context of neurodegenerative diseases but also in relation to other pathologies where these processes are involved.
Parkinson S Disease
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Author : Patrik Verstreken
language : en
Publisher: Academic Press
Release Date : 2016-12-19
Parkinson S Disease written by Patrik Verstreken and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-19 with Science categories.
Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease
Autophagy Of The Nervous System
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Author : Zhenyu Yue
language : en
Publisher: World Scientific
Release Date : 2012
Autophagy Of The Nervous System written by Zhenyu Yue and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy.
Role Of The Mediterranean Diet In The Brain And Neurodegenerative Diseases
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Author : Tahira Farooqui
language : en
Publisher: Academic Press
Release Date : 2017-10-24
Role Of The Mediterranean Diet In The Brain And Neurodegenerative Diseases written by Tahira Farooqui and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-24 with Science categories.
Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative diseases as well as signal transduction. The Mediterranean diet is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat and processed meat products. High consumption of dietary fiber, low glycemic index and glycemic load, anti-inflammatory effects, and antioxidant compounds may act together to produce favorable effects on health status. Collective evidence suggests that Mediterranean diet not only increases longevity by lowering cardiovascular disease, inhibiting cancer growth, but also by protecting the body from age-dependent cognitive decline. Comprehensively provides an overview of the effects of the Mediterranean diet on the brain and its beneficial effects in neurodegenerative diseases Discusses the relationship among Type 2 Diabetes, Metabolic Syndrome and Alzheimer's Disease, and the effect of the Mediterranean diet on normal aging, longevity, and other neurodegenerative diseases Focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative disease
Alzheimer S And Parkinson S Diseases
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Author : Israel Hanin
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Alzheimer S And Parkinson S Diseases written by Israel Hanin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
This book represents the third in a series of International Conferences related to Alzheimer's (AD) and Parkinson's (PD) diseases. The first one took place in Eilat, Israel, in 1985; and the second one in Kyoto, Japan, in 1989. This book contains the full text of oral and poster presentations from the Third International Conference on Alzheimer's and Parkinson's Diseases: Recent Developments, held in Chicago, Illinois, U.S.A. on November 1-6, 1993. The Chicago Conference was attended by 270 participants. The Scientific Program was divided into nine oral sessions, a keynote presentation, and a poster session. The conference culminated in a Round Table Discussion involving all of the participants in the conference. The four and one-half day meeting served as an excellent medium for surveying the current status of clinical and preclinical developments in AD and PD. There were 59 oral presentations and 93 posters. This book incorporates a majority of both.
The Molecular And Cellular Basis Of Neurodegenerative Diseases
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Author : Michael S. Wolfe
language : en
Publisher: Academic Press
Release Date : 2018-03-29
The Molecular And Cellular Basis Of Neurodegenerative Diseases written by Michael S. Wolfe and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-29 with Medical categories.
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts
Ciba Foundation Symposium Bilharziasis
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Author : Gordon Ethelbert Ward Wolstenholme
language : en
Publisher:
Release Date : 1962
Ciba Foundation Symposium Bilharziasis written by Gordon Ethelbert Ward Wolstenholme and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1962 with Schistosomiasis categories.
Oxidative Stress And Neurodegenerative Disorders
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Author : G. Ali Qureshi
language : en
Publisher: Elsevier
Release Date : 2007-03-22
Oxidative Stress And Neurodegenerative Disorders written by G. Ali Qureshi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-22 with Science categories.
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems