Cell Movement And Neoplasia
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Cell Movement And Neoplasia
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Author : M. De Brabander
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Cell Movement And Neoplasia written by M. De Brabander and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Cell Movement and Neoplasia presents the proceedings of the annual meeting of the Cell Tissue and Organ Culture Study Group, held at the Janssen Research Foundation, Beerse, Belgium, in May 1979. The book covers papers about the structural functional correlates in cell movement and invasion and an approach to the in vitro study of neoplastic cell social behavior with a light microscopy method of bidirectional image transfer. The text then presents papers about cell interactions and invasion in vitro and cell movement and invasion in vivo. Geneticists, oncologists, pathologists, cytologists, and other scientists from diverse disciplines will find the book invaluable.
The Actin Cytoskeleton In Cell Motility Cancer And Infection
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Author : Joel Pardee
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2010
The Actin Cytoskeleton In Cell Motility Cancer And Infection written by Joel Pardee and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Science categories.
The cell is no longer considered to be a bag full of enzymes dissolved in a liquid cytoplasm. It is now known that the cytoplasm is an exquisitely ordered structure of properly placed organelles and enzyme complexes that are suspended from an intricate network of structural protein polymers termed the cytoskeleton. All movement of organelles and vesicles within the cell is regulated by this cytoskeleton, and it is clear that the cytoskeleton is responsible for all of the cell's external movement as well. In this lecture, we will consider how the cytoskeleton elicits cell migration.The three main elements of the cytoskeleton are microtubules, intermediate filaments, and actin filaments. Microtubules are essential for (a) intracellular transport within the cytoplasm and transport between the nucleus and cytoplasm, (b) the structure and movement of all cilia and flagella, and (c) the structure of the mitotic spindle and movement of chromosomes on the spindle during cell division. Intermediate filaments give structural integrity to virtually all cells and tissues by providing an intracellular network of flexible cables that strengthen internal cell structure and stabilize cell-to-cell adhesion. It is this intercellular binding property that stably joins epithelial cells together to provide the protective functions of skin and the integrity of the intestinal mucosa.Actin is a highly conserved protein ubiquitous to all eukaryotic cells. Actin is absolutely required for (a) cell migration, (b) the contraction of muscle (both striated and smooth), (c) the structure and function of many cell protrusions (e.g., microvilli, filopodia, lamellopodia, blood platelet projections), (d) division of the cytoplasm (cytokinesis) during telophase of cell mitosis, and (e) movement and placement of organelles within the cell. Actin filaments are also called thin filaments because of their very slender (70 Ã…) diameter.
Cell Movement
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Author : Thomas Abreu
language : en
Publisher: Nova Science Publishers
Release Date : 2009
Cell Movement written by Thomas Abreu and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Cell differentiation categories.
Cell movement is a complex phenomenon primarily driven by the actin network beneath the cell membrane, and can be divided into three general components: protrusion of the leading edge of the cell, adhesion of the leading edge and deadhesion at the cell body and rear, and cytoskeletal contraction to pull the cell forward. Each of these steps is driven by physical forces generated by unique segments of the cytoskeleton. This review examines the specific physics underlying these phases of cell movement and the origins of the forces that drive locomotion. Cell movement or motility is a highly dynamic phenomenon that is essential to a variety of biological processes such as the development of an organism (morphogenesis), wound healing, cancer metastasis and immune response. For example, during morphogenesis there is a targeted movement of dividing cells to specific sites to form tissues and organs. For wound healing to occur, cells such as neutrophils (white blood cells) and macrophages (cells that ingest bacteria) move to the wound site to kill the microorganisms that cause infection, and fibroblasts (connective tissue cells) move there to remodel damaged structures. This book presents important research in the field from around the globe.
Cell Migration In Development And Disease
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Author : Doris Wedlich
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Cell Migration In Development And Disease written by Doris Wedlich and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
Cell Migration matches nearly all research areas in cell and developmental biology, genetics, and biomedicine. The field shows radical progress powered by the combination of new genomic tools, cell labeling techniques and the incorporation of new model systems. This is the first book to comprehensively cover cell migration from the identification of molecular mechanisms to the understanding of certain pathological disorders and cancer development.
Cell Motility In Cancer Invasion And Metastasis
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Author : Alan Wells
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-02-02
Cell Motility In Cancer Invasion And Metastasis written by Alan Wells and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02-02 with Medical categories.
Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.
The Cell Surface In Embryogenesis And Carcinogenesis
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Author : Sanders
language : en
Publisher: CRC Press
Release Date : 1989-11-15
The Cell Surface In Embryogenesis And Carcinogenesis written by Sanders and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-11-15 with Science categories.
This book covers recent trends in the study of cell surfaces, cell interactions, and cell behavior during selected events in development and cancer. It relates current thrusts in molecular biology to more cellular aspects of these fields and draws parallels between advances in developmental biology, malignant invasiveness, wound healing, and regeneration. The book opens with a discussion of a number of developmental events, stressing the importance of the cell surface and extracellular matrix to morphogenesis, cell locomotion, and invasiveness. Basement membranes are discussed in terms of their activity as substrata for cell movement, barriers to invasion, and their role in epithelial-mesenchymal interactions. These aspects of cell-cell and cell-matrix interaction are directly compared with developmental and neoplastic events, emphasizing the epithelial-to-mesenchymal transformations that are common to both of these situations. Other topics discussed include cell surface considerations, cell-cell adhesion, cell-substratum adhesion, as well as a discussion regarding how these topics are relevant to the cell biology of wound healing and regeneration. This book is ideal for researchers and students in biology, cell biology, biochemistry, molecular biology, anatomy, zoology, and medicine.
Cell Motility Factors
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Author : I. Goldberg
language : en
Publisher: Birkhäuser
Release Date : 2013-03-09
Cell Motility Factors written by I. Goldberg and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
Differentiation And Neoplasia
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Author : R. G. McKinnell
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Differentiation And Neoplasia written by R. G. McKinnell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
There is no commonly accepted mechanism to explain differentiation of either normal or neoplastic cells. Despite this fact, the organizers of the 3 rd International Conference on Differentiation recognized that there is much emerging evidence which supports the view that both normal cells and many cancer cells share common differentiative processes. Accordingly, the organizers perceived that clinical scientists and developmental biologists would greatly benefit by together considering differentiation. In that way, developmental biologists would be apprised of recent insights in cancer cell biology and the physician scientist would be updated on events in developmental biology and both would gain new understanding of the cell biology of neoplasia. A specific example may reveal the potential value of developmental biologists interacting with cancer physicians. An example chosen at random suggests that probably any paper included in the symposium volume would serve the purpose. Dr. Stephen Subtelny reviewed recent studies by his laboratory concerning germ cell migration and replication in frog embryos. How might those results interest the cancer scientist? Dr. Subtelny showed that primordial germ cells of a fertile graft will reverse their migratory direction and move into a sterile host. Perhaps in this context it would not be inappropriate to state that the germ cells of the graft metastasized into the host. Germ cells from grafts of a different species will populate the previously sterile host gonad.
Actin Cytoskeleton In Cancer Progression And Metastasis Part B
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-10-14
Actin Cytoskeleton In Cancer Progression And Metastasis Part B written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-14 with Science categories.
Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, and in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Specific chapters in this release cover Actin dynamics during tumor cell dissemination, Actin cytoskeleton remodeling during cancer cell migration, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and much more. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Actin Cytoskeleton In Cancer Progression And Metastasis
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Author : Lorenzo Galluzzi
language : en
Publisher: Elsevier
Release Date : 2021
Actin Cytoskeleton In Cancer Progression And Metastasis written by Lorenzo Galluzzi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.