Cell Signaling In Host Pathogen Interactions The Host Point Of View
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Cell Signaling In Host Pathogen Interactions The Host Point Of View
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Author : Diana Bahia
language : en
Publisher: Frontiers Media SA
Release Date : 2018-03-23
Cell Signaling In Host Pathogen Interactions The Host Point Of View written by Diana Bahia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-23 with categories.
The ability of pathogens, such as parasites, bacteria, fungi and viruses to invade, persist and adapt in both invertebrate and vertebrate hosts is multifactorial and depends on both pathogen and host fitness. Communication between a pathogen and its host relies on a wide and dynamic array of molecular interactions. Through this constant communication most pathogens evolved to be relatively benign, whereas killing of its host by a pathogen represents a failure to adapt. Pathogens are lethal to their host when their interaction has not been long enough for adaptation. Evolution has selected conserved immune receptors that recognize signature patterns of pathogens as non-self elements and initiate host innate responses aimed at eradicating infection. Conversely, pathogens evolved mechanisms to evade immune recognition and subvert cytokine secretion in order to survive, replicate and cause disease. The cell signaling machinery is a critical component of the immune system that relays information from the receptors to the nucleus where transcription of key immune genes is activated. Host cells have developed signal transduction systems to maintain homeostasis with pathogens. Most cellular processes and cell signaling pathways are tightly regulated by protein phosphorylation in which protein kinases are key protagonists. Pathogens have developed multiple mechanisms to subvert important signal transduction pathways such as the mitogen activated protein kinase (MAPK) and the nuclear factor kB (NF-kB) pathways. Pathogens also secrete effectors that manipulate actin cytoskeleton and its regulators, hijack cell cycle machinery and alter vesicular trafficking. This research topic focuses on the cellular signaling mechanisms that are essential for host immunity and their subversion by pathogens.
Systems Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-08-24
Systems Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-24 with Science categories.
Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information
Macrophages
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Author : Vijay Kumar
language : en
Publisher: BoD – Books on Demand
Release Date : 2022-12-14
Macrophages written by Vijay Kumar and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-14 with Medical categories.
Macrophages were first discovered in 1882 when Elia Metchnikoff recognized them as important phagocytic cells that can engulf any foreign material, including fungal spores. This discovery has proved to be a milestone in establishing the field of innate immunity. Macrophages are still ruling the area after 140 years of their discovery. This book explores the diverse role of macrophages in vertebrate immunity, parasitic, bacterial, and viral infections, regeneration, inflammation, and neurological diseases.
Cellular Microbiology
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Author : Pascale Cossart
language : en
Publisher:
Release Date : 2000
Cellular Microbiology written by Pascale Cossart and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
This text links the fields of microbiology and cell biology. Cellular Microbiology is a new upper-level textbook which describes the.
Coronavirus Therapeutics Volume Ii
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Nature
Release Date : 2022-02-08
Coronavirus Therapeutics Volume Ii written by Alexzander A. A. Asea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-08 with Medical categories.
The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Shaping Of Human Immune System And Metabolic Processes By Viruses And Microorganisms
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Author : Marina I. Arleevskaya
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-15
Shaping Of Human Immune System And Metabolic Processes By Viruses And Microorganisms written by Marina I. Arleevskaya and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-15 with categories.
Recent advances in the understanding of microbiota in health and diseases are presented in this special issue of Frontiers in Immunology and Frontiers in Microbiology as well as their impact on the immune system that can lead to the development of pathologies. Potential perspectives and biomarkers are also addressed. We offer this Research Topic involving 64 articles and 501 authors to discuss recent advances regarding: 1. An overview of the human microbiota and its capacity to interact with the human immune system and metabolic processes, 2. New developments in understanding the immune system’s strategies to respond to infections and escape strategies used by pathogens to counteract such responses, 3. The link between the microbiota and pathology in terms of autoimmunity, allergy, cancers and other diseases.
Intracellular Infectious Diseases
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Author : Feng Lu
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-25
Intracellular Infectious Diseases written by Feng Lu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-25 with Science categories.
Applied Mycology
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Author : Mahendra Rai
language : en
Publisher: CABI
Release Date : 2009-01-01
Applied Mycology written by Mahendra Rai and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-01 with Science categories.
This book is intended to provide both students and researchers with a broad background to some of the fastest developing areas in current applied mycology. A range of contributions are given to highlight the diverse nature of current applied mycology research. The opening chapter of this volume provides some examples of how mycology is often neglected, and presents a case for considering mycology as a megascience. The subsequent chapters have been loosely grouped into four sections in order to reflect the wider 'customers' or context of the particular mycological areas or activities. In each section, contributions that show either new applications or developments of well-established technology, or novel research into new technology or environments are included. The section on environment, agriculture and forestry is represented by contributions that illustrate novel fungal associations or new aspects of well-known interactions. The section on foods and medicine reflects the long history of applied mycology in the manufacture of alcoholic beverages, with two chapters devoted to beer production and winery spoilage issues. Chapters in the section on biotechnology and emerging science reflect some of the current interests in fungal enzymes and their importance in broader environmental processes and applications.
Novel Approaches In Microbiome Analyses And Data Visualization
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Author : Jessica Galloway-Peña
language : en
Publisher: Frontiers Media SA
Release Date : 2019-02-06
Novel Approaches In Microbiome Analyses And Data Visualization written by Jessica Galloway-Peña and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with categories.
High-throughput sequencing technologies are widely used to study microbial ecology across species and habitats in order to understand the impacts of microbial communities on host health, metabolism, and the environment. Due to the dynamic nature of microbial communities, longitudinal microbiome analyses play an essential role in these types of investigations. Key questions in microbiome studies aim at identifying specific microbial taxa, enterotypes, genes, or metabolites associated with specific outcomes, as well as potential factors that influence microbial communities. However, the characteristics of microbiome data, such as sparsity and skewedness, combined with the nature of data collection, reflected often as uneven sampling or missing data, make commonly employed statistical approaches to handle repeated measures in longitudinal studies inadequate. Therefore, many researchers have begun to investigate methods that could improve incorporating these features when studying clinical, host, metabolic, or environmental associations with longitudinal microbiome data. In addition to the inferential aspect, it is also becoming apparent that visualization of high dimensional data in a way which is both intelligible and comprehensive is another difficult challenge that microbiome researchers face. Visualization is crucial in both the analysis and understanding of metagenomic data. Researchers must create clear graphic representations that give biological insight without being overly complicated. Thus, this Research Topic seeks to both review and provide novels approaches that are being developed to integrate microbiome data and complex metadata into meaningful mathematical, statistical and computational models. We believe this topic is fundamental to understanding the importance of microbial communities and provides a useful reference for other investigators approaching the field.
Plants As Alternative Hosts For Human And Animal Pathogens
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Author : Nicola J. Holden
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-02
Plants As Alternative Hosts For Human And Animal Pathogens written by Nicola J. Holden and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-02 with Botany categories.
Many of the most prevalent and devastating human and animal pathogens have part of their lifecycle out-with the animal host. These pathogens have a remarkably wide capacity to adapt to a range of quite different environments: physical, chemical and biological, which is part of the key to their success. Many of the well-known pathogens that are able to jump between hosts in different biological kingdoms are transmitted through the faecal-oral and direct transmission pathways, and as such have become important food-borne pathogens. Some high-profile examples include fresh produce-associated outbreaks of Escherichia coli O157:H7 and Salmonella enterica. Other pathogens may be transmitted via direct contact or aerosols are include important zoonotic pathogens. It is possible to make a broad division between those pathogens that are passively transmitted via vectors and need the animal host for replication (e.g. virus and parasites), and those that are able to actively interact with alternative hosts, where they can proliferate (e.g. the enteric bacteria). This research topic will focus on plants as alternative hosts for human pathogens, and the role of plants in their transmission back to humans. The area is particularly exciting because it opens up new aspects to the biology of some microbes already considered to be very well characterised. One aspect of cross-kingdom host colonisation is in the comparison between the hosts and how the microbes are able to use both common and specific adaptations for each situation. The area is still in relative infancy and there are far more questions than answers at present. We aim to address important questions underlying the interactions for both the microbe and plant host in this research topic.