Novel Approaches In Microbiome Analyses And Data Visualization
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Novel Approaches In Microbiome Analyses And Data Visualization
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Author : Jessica Galloway-Peña
language : en
Publisher: Frontiers Media SA
Release Date : 2019-02-06
Novel Approaches In Microbiome Analyses And Data Visualization written by Jessica Galloway-Peña and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with categories.
High-throughput sequencing technologies are widely used to study microbial ecology across species and habitats in order to understand the impacts of microbial communities on host health, metabolism, and the environment. Due to the dynamic nature of microbial communities, longitudinal microbiome analyses play an essential role in these types of investigations. Key questions in microbiome studies aim at identifying specific microbial taxa, enterotypes, genes, or metabolites associated with specific outcomes, as well as potential factors that influence microbial communities. However, the characteristics of microbiome data, such as sparsity and skewedness, combined with the nature of data collection, reflected often as uneven sampling or missing data, make commonly employed statistical approaches to handle repeated measures in longitudinal studies inadequate. Therefore, many researchers have begun to investigate methods that could improve incorporating these features when studying clinical, host, metabolic, or environmental associations with longitudinal microbiome data. In addition to the inferential aspect, it is also becoming apparent that visualization of high dimensional data in a way which is both intelligible and comprehensive is another difficult challenge that microbiome researchers face. Visualization is crucial in both the analysis and understanding of metagenomic data. Researchers must create clear graphic representations that give biological insight without being overly complicated. Thus, this Research Topic seeks to both review and provide novels approaches that are being developed to integrate microbiome data and complex metadata into meaningful mathematical, statistical and computational models. We believe this topic is fundamental to understanding the importance of microbial communities and provides a useful reference for other investigators approaching the field.
Insights In Systems Microbiology 2021
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Author : George Tsiamis
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-06
Insights In Systems Microbiology 2021 written by George Tsiamis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-06 with Science categories.
Epigenetics In The Microbiome Host Crosstalk From Mechanisms To Therapeutics
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Author : Chengfei Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-01
Epigenetics In The Microbiome Host Crosstalk From Mechanisms To Therapeutics written by Chengfei Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-01 with Medical categories.
Epigenetic modifications allow cells to change gene expression without altering the genetic code, by dynamically regulating chromatin accessibility, which is controlled by the activity of associated enzymes such as DNA/histone methyltransferases and histone acetyltransferases. This represents a potent mechanism through which mammalian hosts adapt their transcriptional program to environmental cues. Indeed, trillions of commensal microbes, termed microbiota, along with their metabolites and their signaling, are environmental stimuli that can direct host health and disease. They are being increasingly recognized as a source of epigenetic substrates, cofactors, and regulators of epigenetic-modifying enzymes. Recent research has shown that perturbation of microbiota-host interactions with pathologies of inflammatory diseases or metabolic syndrome correlated with altered epigenetic patterning. Microbiota-sensitive epigenetic mechanisms may include synthesizing biological compounds that affect the availability of methyl/ acetyl donors for DNA or histone modifications; modulating epigenetic modifying enzyme activity; influencing host-cell intrinsic epigenetic pathways; or regulating non-coding RNAs. Nevertheless, a deeper understanding of this epigenetic regulation is required in guiding therapeutic approaches to prevent or combat diseases driven by disrupted microbiota-host crosstalk.
Biocomputing 2017 Proceedings Of The Pacific Symposium
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Author : Russ B Altman
language : en
Publisher: World Scientific
Release Date : 2016-11-23
Biocomputing 2017 Proceedings Of The Pacific Symposium written by Russ B Altman and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-23 with Science categories.
The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 - 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
Innovative Approaches To Promote Stroke Recovery
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Author : Rupert Ortner
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-05
Innovative Approaches To Promote Stroke Recovery written by Rupert Ortner and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-05 with Science categories.
Stroke is a leading cause of long-term disability, affecting millions of individuals worldwide. The path to recovery after a stroke can be challenging, involving physical, cognitive, and emotional rehabilitation. Traditional approaches to stroke recovery have provided important insights into rehabilitation techniques. However, there is a need for innovative approaches that can further enhance the recovery process, improve outcomes, and promote the restoration of functional abilities. This research topic aims to explore and showcase the latest advancements and novel approaches in stroke recovery. By delving into cutting-edge techniques, technologies, and interventions, we seek to contribute to the development of innovative and evidence-based strategies that can optimize stroke rehabilitation and improve the lives of stroke survivors. The research topic will cover various aspects related to innovative approaches in stroke recovery, including: • Technology-Based Interventions: Explore the use of virtual reality, robotics, sensors, and wearables in stroke rehabilitation to enhance motor and cognitive therapy. • Personalized Rehabilitation: Investigate the use of artificial intelligence, machine learning, and data analytics to tailor rehabilitation programs to the specific needs of stroke survivors. • Non-Invasive Brain Stimulation: Investigate the effectiveness of transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES) in promoting motor function, cognitive abilities, and neuroplasticity. • Pharmacological Interventions: Study the potential of neuroprotective agents and drugs targeting neuroplasticity to enhance recovery and address post-stroke complications.
Microbiome In Human Health And Disease
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Author : Pallaval Veera Bramhachari
language : en
Publisher: Springer Nature
Release Date : 2021-10-18
Microbiome In Human Health And Disease written by Pallaval Veera Bramhachari and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-18 with Medical categories.
The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.
Microbiome Analysis
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Author : Robert G. Beiko
language : en
Publisher:
Release Date : 2018
Microbiome Analysis written by Robert G. Beiko and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Microbiology categories.
Microbiome And Machine Learning
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Author : Isabel Moreno Indias
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-02
Microbiome And Machine Learning written by Isabel Moreno Indias and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-02 with Science categories.
The Human Microbiota
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Author : David N. Fredricks
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-22
The Human Microbiota written by David N. Fredricks and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-22 with Science categories.
The Human Microbiota offers a comprehensive review of all human-associated microbial niches in a single volume, focusing on what modern tools in molecular microbiology are revealing about human microbiota, and how specific microbial communities can be associated with either beneficial effects or diseases. An excellent resource for microbiologists, physicians, infectious disease specialists, and others in the field, the book describes the latest research findings and evaluates the most innovative research approaches and technologies. Perspectives from pioneers in human microbial ecology are provided throughout.
Computational Methods For Microbiome Analysis
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Author : Joao Carlos Setubal
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-02
Computational Methods For Microbiome Analysis written by Joao Carlos Setubal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-02 with Science categories.