Cell Signaling Pathways And Their Therapeutic Implication In Cancers
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Cell Signaling Pathways And Their Therapeutic Implication In Cancers
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Author : Muneeb U. Rehman
language : en
Publisher: Springer Nature
Release Date : 2025-03-28
Cell Signaling Pathways And Their Therapeutic Implication In Cancers written by Muneeb U. Rehman and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-28 with Medical categories.
This book discusses different signaling pathways involved in tumor development and progression. It discusses the pathways that allow tumor cells to proliferate, survive, and invade other tissues. Further, the book reviews the signal transduction regulating phagocytosis, production of cytokines, cell division, and differentiation. It elucidates the dysregulation of cellular signal transduction induced by the genetic and epigenetic changes that drive cancer and enumerates the signaling network encompassing the extracellular matrix, blood vessels, and the immune system. Additionally, the book provides mechanistic insights into inhibitors of the receptor tyrosine kinases, BRAF, EGFR, and ALK that improve clinical response and increase the survival of patients with cancer. The book covers the signal transduction pathways that regulate cell cycle progression and genomic stability, providing a mechanistic understanding of the major checkpoint pathways, and reviewing their diagnostic and therapeutic potential. This volume is essential reading for researchers to understand the therapeutic potential of important signaling molecules against cancer.
Breast Cancer Chronicles From Awareness To Wellness
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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date :
Breast Cancer Chronicles From Awareness To Wellness written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
In "Breast Cancer Chronicles: From Awareness to Wellness," embark on a transformative journey through the multifaceted world of breast cancer. This comprehensive treatise is your ultimate guide to understanding breast cancer, its prevention, holistic well-being, and advocacy for change. Seamlessly blending medical insights, holistic approaches, and patient perspectives, this book is an invaluable resource for individuals seeking to enhance their breast health, reduce risk, and embrace a holistic way of life. Uncover the intricacies of breast cancer, from its definition and classification to epidemiology, genetic predisposition, and pathogenesis. Gain insight into clinical presentations, diagnostic modalities, and advanced treatments, equipping yourself with knowledge that can make a difference in your life or the lives of loved ones. But this treatise goes beyond medical details. It delves into holistic approaches to breast health, including lifestyle modifications, mindfulness practices, and the significance of mental well-being. Learn how to nurture your mind, body, and spirit to reduce the risk of breast cancer and promote overall wellness. Discover the vital role of breast cancer advocacy and education in driving change and raising awareness. Read inspiring survivor stories and gain empowering insights from those who have journeyed through breast cancer and emerged stronger advocates for change.
Molecular Mechanisms Of Cellular Stress Responses In Cancer And Their Therapeutic Implications
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Author : Megan Chircop
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-06
Molecular Mechanisms Of Cellular Stress Responses In Cancer And Their Therapeutic Implications written by Megan Chircop and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-06 with Carcinogenesis categories.
In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required. This Research topic aims to reflect the broadness and complexity of this important area of cancer research.
Cancer Stem Cells Basic Concept And Therapeutic Implications
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Author : Farhadul Islam
language : en
Publisher: Springer Nature
Release Date : 2023-07-26
Cancer Stem Cells Basic Concept And Therapeutic Implications written by Farhadul Islam and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-26 with Medical categories.
This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
Cell Signaling
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Author : Adeeb Shehzad
language : en
Publisher: CRC Press
Release Date : 2025-04-17
Cell Signaling written by Adeeb Shehzad and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-17 with Science categories.
This book provides a comprehensive understanding of cell signaling, molecular interactions, and their implications for human health and diseases. It introduces fundamental principles underlying cell communication through signaling molecules and their diverse transmission and reception mechanisms, highlighting their role in intercellular communication through voltage- and ion-gated channels, immunological and neuron synapses, and rhinovirus–receptor interaction involved in pathogenesis and disease development. Toward the end, the book highlights the profound implications of altered cell signaling pathways in the inflammation and immune response followed by the progression of various disorders, including cancer, endocrine disorders, and neurological illnesses. It explores the diagnostic and therapeutic implications of cell signaling in targeted therapies, highlighting advanced techniques for detecting signaling molecules and innovative therapeutic approaches to inspire new developments in precision medicine. It serves as an important resource for academics, students, and professionals in the fields of cell biology and biomedical sciences. Key Features: Provides in-depth understanding of cell signaling, exploring its complexities and impact on human health and disease Introduces fundamental principles of cell communication, emphasizing the different signaling molecules and their various transmission pathways Focuses on complex structures and functions of receptors, highlighting their essential role in intercellular communication and regulating cellular behavior Examines the molecular aspects of cell surface adhesion receptors, elucidating protein–protein interactions, signaling cascades, and enzyme–substrate interactions Discusses the impact of cell signaling on inflammation, cancer, and endocrine and neurological disorders
Targeting Signaling Pathways In Solid Tumors Part B
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-05-24
Targeting Signaling Pathways In Solid Tumors Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-24 with Science categories.
Targetting Signaling Pathways in Solid tumour Part B, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike
Cancer Plasticity And The Microenvironment Implications For Immunity And Therapy Response
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Author : Petranel T. Ferrao
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-01
Cancer Plasticity And The Microenvironment Implications For Immunity And Therapy Response written by Petranel T. Ferrao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-01 with categories.
Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.
Malignant Neoplasm Of The Parotid Gland A Comprehensive Exploration
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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date :
Malignant Neoplasm Of The Parotid Gland A Comprehensive Exploration written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
Unlock the mysteries of one of the most intricate and lesser-known cancers with "Malignant Neoplasm of the Parotid Gland: A Comprehensive Exploration." This groundbreaking treatise delves deep into the complexities of parotid gland tumors, offering readers a blend of scientific rigor and clinical insights. From the cellular origins of malignant neoplasms to the latest treatment modalities, this book serves as a definitive guide for both medical professionals and those personally touched by this condition. The parotid gland, a crucial salivary gland, is intricately detailed, shedding light on its anatomy, function, and the unique challenges posed by tumors originating here. This treatise is a treasure trove of information, encompassing genetic factors, cutting-edge research trends, and the role of lifestyle in cancer prevention. It doesn't stop at the technicalities; readers will also find poignant patient stories, offering a firsthand look into the emotional and psychological facets of dealing with a parotid gland malignancy. As the global medical community continues its relentless pursuit against cancer, "Malignant Neoplasm of the Parotid Gland" stands out as a beacon of knowledge, hope, and inspiration. Whether you're a seasoned oncologist, a medical student, or someone seeking to understand a diagnosis, this book promises to be an invaluable resource.
Natural Compounds And Their Role In Apoptotic Cell Signaling Pathways Volume 1171
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Author : Marc Diederich
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-08
Natural Compounds And Their Role In Apoptotic Cell Signaling Pathways Volume 1171 written by Marc Diederich and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-08 with Science categories.
Apoptosis is a highly regulated mechanism by which cells undergo cell death in an active way. As one of the most challenging tasks concerning cancer is to induce apoptosis in malignant cells, researchers increasingly focus on natural products to modulate apoptotic signaling pathways. This book reviews the main effects of natural compounds on the different apoptotic signaling pathways, including the intrinsic and extrinsic apoptosis pathways, the NF-kB-mediated pathway, the PI3K/Akt signaling, and other main pathways. Among the topic specially covered are: Effects of natural compounds on cancer cells Natural compounds as inducers of cell death Diet in health and disease Inflammation and cancer Natural compounds as kinase inhibitors Natural compounds in neurodegenerative diseases Natural compounds as inhibitors of ROS NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Biosensors And Aptamers
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Author : Shriyansh Srivastava
language : en
Publisher: Springer Nature
Release Date : 2025-07-25
Biosensors And Aptamers written by Shriyansh Srivastava and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-25 with Medical categories.
The book explores the latest advancements in medical and life sciences, revealing the transformative potential of biosensors and aptamers in combating cancer. These cutting-edge technologies revolutionize diagnosis with unprecedented accuracy and early detection of cancer. The chapters cover advancements in targeted therapy, where aptamers deliver personalized treatments with remarkable precision, minimizing side effects and maximizing efficacy. It highlights real-world applications, success stories, and the pursuit of more effective and humane cancer diagnosis and treatment. The book is intended for clinicians and students.