Molecular Mechanisms Of Cellular Stress Responses In Cancer And Their Therapeutic Implications
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Molecular Mechanisms Of Cellular Stress Responses In Cancer And Their Therapeutic Implications
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Author : Megan Chircop
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-06
Molecular Mechanisms Of Cellular Stress Responses In Cancer And Their Therapeutic Implications written by Megan Chircop and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-06 with Carcinogenesis categories.
In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required. This Research topic aims to reflect the broadness and complexity of this important area of cancer research.
Introduction For Heart 3d Bioprinting Book 2
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date : 2024-05-18
Introduction For Heart 3d Bioprinting Book 2 written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-18 with Medical categories.
The realm of bioprinting, especially 3D bioprinting of complex organs such as the heart, is at the forefront of modern medical science. This book, "Introduction to Heart 3D Bioprinting - Introduction to Cell Biology and The 3D Bioprinting," serves as a comprehensive guide to understanding the intricate relationship between cell biology and the innovative field of 3D bioprinting. In the rapidly advancing field of bioprinting, the ability to create functional heart tissues and eventually whole organs holds immense promise for addressing the global shortage of donor organs and improving outcomes for patients with severe cardiovascular diseases. However, this ambition requires a profound understanding of cell biology, tissue engineering, and the bioprinting technologies that can bring these visions to reality. This book is divided into two primary sections. The first section delves into the fundamentals of cell biology, providing detailed insights into cellular mechanisms, structures, and processes that are crucial for anyone looking to explore or work in the field of bioprinting. Topics such as cytoskeleton regulation, cellular respiration, DNA replication, and stem cell biology are meticulously covered to lay a robust foundation for understanding how cells can be manipulated and utilized in bioprinting applications. It explores the techniques, materials, and technologies used to create three-dimensional biological structures. This section discusses the integration of cells into bioprinted constructs, the challenges of mimicking the complex architecture of the heart, and the innovative solutions being developed to overcome these hurdles. Together, these sections provide a detailed roadmap from the basic principles of cell biology to the cutting-edge applications of 3D bioprinting. Whether you are a student, researcher, or practitioner, this book aims to equip you with the knowledge and tools necessary to contribute to the exciting advancements in heart 3D bioprinting. I would like to express my gratitude to the countless researchers and pioneers in the fields of cell biology and bioprinting whose work has made this book possible. Their dedication to advancing science and medicine inspires us to push the boundaries of what is possible and strive for innovations that can transform lives.
Introduction For Heart 3d Bioprinting Livro 1
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date : 2024-05-18
Introduction For Heart 3d Bioprinting Livro 1 written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-18 with Medical categories.
The advent of 3D bioprinting technology has opened new frontiers in biomedical science, offering unprecedented possibilities for tissue engineering and regenerative medicine. As we embark on a journey to explore the intricate world of heart 3D bioprinting, a comprehensive understanding of cell biology forms the foundation of our exploration. This book, "Introduction for Heart 3D Bioprinting - Introduction to Cell Biology," aims to bridge the gap between fundamental cellular mechanisms and their applications in advanced bioprinting technologies. The content of this book is meticulously structured to provide readers with a robust framework of cell biology, encompassing a wide range of topics that are crucial for understanding the complexities of cellular functions and their implications in heart tissue engineering. From the basic principles of cell division and DNA repair to the sophisticated mechanisms of signal transduction and metabolic regulation, each chapter is crafted to elucidate the cellular processes that are pivotal for the success of 3D bioprinting in cardiovascular applications. The chapters are organized in a logical sequence, beginning with an introduction to essential cell biology concepts and progressing towards more specialized topics such as cellular senescence, apoptosis, and stem cell therapy. By integrating these concepts, the book not only highlights the biological underpinnings of heart 3D bioprinting but also underscores the therapeutic potential of this technology in addressing cardiovascular diseases. One of the unique aspects of this book is its interdisciplinary approach. While it delves deep into cell biology, it also connects these biological principles with practical applications in bioprinting. This dual focus ensures that readers gain both theoretical knowledge and practical insights, making this book a valuable resource for students, researchers, and professionals in the fields of biomedicine, bioengineering, and tissue engineering. As the field of 3D bioprinting continues to evolve, it is imperative to stay abreast of the latest advancements and understand the fundamental science that drives these innovations. This book endeavors to serve as a foundational text that not only educates but also inspires further research and development in the realm of heart 3D bioprinting. I would like to extend my gratitude to all the researchers, educators, and practitioners whose work has contributed to the knowledge encapsulated in this book. It is my hope that this text will foster a deeper understanding of cell biology and its critical role in the exciting field of heart 3D bioprinting, ultimately contributing to the advancement of medical science and improving patient outcomes.
Stress Response Signaling In Tumor Development And Its Implications For Cancer Treatment
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Author : Shuyu Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-13
Stress Response Signaling In Tumor Development And Its Implications For Cancer Treatment written by Shuyu Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-13 with Medical categories.
Introduction For Liver 3d Bioprinting Book 1
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date : 2024-05-19
Introduction For Liver 3d Bioprinting Book 1 written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-19 with Medical categories.
The field of 3D bioprinting is rapidly evolving, offering unprecedented opportunities for medical and scientific advancements. "Introduction for Liver 3D Bioprinting – Book 1: Introduction to Cell Biology" is the first volume in a comprehensive series dedicated to exploring the intricate relationship between cellular biology and 3D bioprinting technology, specifically focusing on the liver. This book serves as a foundational text, aiming to bridge the gap between basic cell biology and its application in bioprinting. Understanding the principles of cell biology is crucial for anyone involved in tissue engineering, regenerative medicine, and 3D bioprinting, as it provides the essential knowledge needed to manipulate and cultivate cells effectively. In this volume, we delve into various aspects of cell biology, including the mechanisms of cellular processes, the roles of different cellular structures, and the intricacies of cellular signaling pathways. These topics are meticulously chosen to provide a broad yet detailed overview that sets the stage for more specialized discussions in subsequent volumes. Our goal is to equip researchers, students, and professionals with the knowledge required to innovate and excel in the field of 3D bioprinting. Each chapter is designed to build a strong conceptual framework, facilitating a deeper understanding of how cellular functions can be harnessed and manipulated for bioprinting applications. As you embark on this journey through the cellular world, we hope this book will inspire new ideas, foster scientific curiosity, and contribute to the growing body of knowledge in the field of bioprinting. Whether you are a seasoned researcher or new to the subject, this text aims to provide valuable insights and a solid foundation in cell biology, essential for advancing the science and application of 3D bioprinting. Thank you for joining us in exploring the fascinating intersection of cell biology and 3D bioprinting. We look forward to seeing the innovative solutions and breakthroughs that will emerge from your understanding and application of the concepts presented in this book.
Precise Diagnosis Functional Mechanisms And Therapeutic Potentials In Gastrointestinal Cancers Volume Ii
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Author : Zequn Li
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-18
Precise Diagnosis Functional Mechanisms And Therapeutic Potentials In Gastrointestinal Cancers Volume Ii written by Zequn Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-18 with Medical categories.
Significant changes in diet, environment, and population increase gastrointestinal cancer morbidity. A growing number of studies on precise diagnosis and underlying mechanisms are being elucidated, some of which may even conflict with assumptions of past decades. Therefore, collecting recent findings on novel diagnoses and/or risk factors in gastrointestinal cancers is a prerequisite for a better understanding of the disease. Despite remarkable progressions in surgical treatments and chemotherapies, the prognosis of gastrointestinal cancer is far from satisfactory due to the high occurrence of drug resistance. Based on the identification of novel biomarkers as well as their underlying mechanisms, targeted drug development will provide significant complementary therapeutic effects to conventional chemoradiotherapies. High-throughput methods such as next-generation sequencing on RNA level and mass spectrometry on protein/lipid/metabolite level serve as efficient strategies for biomarker identification and drug development.
Apoptosis In Cancer Pathogenesis And Anti Cancer Therapy
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Author : Christopher D. Gregory
language : en
Publisher: Springer
Release Date : 2016-08-24
Apoptosis In Cancer Pathogenesis And Anti Cancer Therapy written by Christopher D. Gregory and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-24 with Medical categories.
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
New Insights Into Intracellular Pathways And Therapeutic Targets In Cns Diseases
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Author : Lisa Gherardini
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-14
New Insights Into Intracellular Pathways And Therapeutic Targets In Cns Diseases written by Lisa Gherardini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-14 with Science categories.
The intracellular signalling network machinery, responding to different micro-environmental cues, regulates all aspects of cellular physiology, including metabolism, gene expression and modification, proliferation, differentiation and programmed cell death. Indeed, changes in the expression of cell surface receptors and/or their mutations, as well as ligand abundance, can have profound effects on cell physiology of the central nervous system and disarray of cell signalling often lies beneath the cause of neuronal diseases. New interesting knowledge has been recently gathered demonstrating the importance of canonical developmental pathways such as Sonic Hedgehog (SHH), Wnt/b-catenin and Notch-3 in neuronal homeostasis. As well, the role of autophagosomes generating pathways has recently been involved in conditions such as neuroinflammation, Alzheimer's and Parkinson’s diseases, brain tumours, and damages due to cerebral ischemia and reperfusion, with a specific attention on the accumulation of ROS-generating damaged mitochondria.
Nanomaterials For Magnetic And Optical Hyperthermia Applications
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Author : Raluca Maria Fratila
language : en
Publisher: Elsevier
Release Date : 2018-11-30
Nanomaterials For Magnetic And Optical Hyperthermia Applications written by Raluca Maria Fratila and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-30 with Science categories.
Nanomaterials for Magnetic and Optical Hyperthermia Applications focuses on the design, fabrication and characterization of nanomaterials (magnetic, gold and hybrid magnetic-gold nanoparticles) for in vitro and in vivo hyperthermia applications, both as standalone and adjuvant therapy in combination with chemotherapy. The book explores the potential for more effective cancer therapy solutions through the synergistic use of nanostructured materials as magnetic and optical hyperthermia agents and targeted drug delivery vehicles, while also discussing the challenges related to their toxicity, regulatory and translational aspects. In particular, the book focuses on the design, synthesis, biofunctionalization and characterization of nanomaterials employed for magnetic and optical hyperthermia. This book will be an important reference resource for scientists working in the areas of biomaterials and biomedicine seeking to learn about the potential of nanomaterials to provide hyperthermia solutions. - Explores the design of efficient nanomaterials for hyperthermia applications, allowing readers to make informed materials selection decisions - Discusses the biofunctionalization of a range of nanomaterials and their interaction with living systems - Provides an overview of the current clinical applications of nanomaterials in hyperthermia treatment
Expert Views On Hpv Infection
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Author : Alison A. McBride
language : en
Publisher: MDPI
Release Date : 2018-05-04
Expert Views On Hpv Infection written by Alison A. McBride and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-04 with Science categories.
This book is a printed edition of the Special Issue "Expert Views on HPV Infection" that was published in Viruses