Cell Surface Aminopeptidases
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Cell Surface Aminopeptidases
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Author : Shigehiko Mizutani
language : en
Publisher:
Release Date : 2001
Cell Surface Aminopeptidases written by Shigehiko Mizutani and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
This book offers unique content for both basic and clinical scientists around the world with an interest in cell-surface peptidases. The book focuses on five cell-surface peptidases, namely neutral endopeptidase (NEP)/CD10, aminopeptidase N (APN)/CD13, aminopeptidase A (APA)/BP1, dipeptidyl peptidase IV (DPPIV)/CD26, and placental leucine aminopeptidase (PLAP)/insulin-regulated aminopeptidase (IRAP), which are members of the type II membrane-bound peptidase family. It reviews the recent progress in these peptidases as well as their peptide substrates, and explores their physiological and pathological significance. Key features include: a new insight into the regulation of blood pressure and peripheral vascular systems; research into a new mechanism for insulin-responsive glucose transport and its application for the treatment of diabetes; and understanding of the new mechanisms of cell-survival peptidase involvement in human tumor progression
Cell Surface Peptidases In Health And Disease
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Author : A.J. Kenny
language : en
Publisher: Taylor & Francis
Release Date : 1997-07
Cell Surface Peptidases In Health And Disease written by A.J. Kenny and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-07 with Medical categories.
Cells bristle with a battery of surface enzymes, of which the peptidases form the largest and best studied group. These ectopeptidases play crucial roles in many diverse biological functions, including the termination of peptide signals in the nervous system and at peripheral sites. Some of their key physiological roles, such as those of angiotensin- and endothelin-converting enzymes in generating vasoconstrictive agents and endopeptidase-24.11 in activating natriuretic peptides, enkephalins and tachykinins, have made them prime targets for the pharmaceutical industry. Interest among immunologists and haematologists was aroused when several were shown to be identical to cell-surface markers (CD antigens) on human leukocytes. Virologists have been excited to find that some double as receptors for certain viruses.
Aminopeptidases In Biology And Disease
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Author : Nigel M. Hooper
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Aminopeptidases In Biology And Disease written by Nigel M. Hooper and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease.
Dipeptidyl Aminopeptidases
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Author : Uwe Lendeckel
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-12-11
Dipeptidyl Aminopeptidases written by Uwe Lendeckel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-11 with Medical categories.
This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.
Ectopeptidases
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Author : Jürgen Langner
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Ectopeptidases written by Jürgen Langner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The idea to compile recent results on the ectoenzymes aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 arose from the great interest given by readers world-wide to the two proceedings volumes edited by us in 1997 and 2000 (Ansorge and Langner, 1997; Langner and Ansorge, 2000). These volumes contained the presentations at two symposia held in Magdeburg (Germany) in 1996 and 1999 under the title "Cellular peptidases in immune functions and diseases", which was also the name of the Sonderforschungsbereich in Magdeburg, sponsored by the Deutsche Forschungsgemeinschaft between 1995 and 2001. Our groups in Magdeburg and Halle during the last two decades have provided results on these two enzymes in cells of the hematopoietic system that justify a review in an edited monograph like the present one (see the reviews by Kahne et at. , 1999; Lendeckel et at. ,1999; Riemann et at. , 1999). There are, however, many other groups in Europe, US and Japan which made important contributions to this field and particularly in topics improving the understanding of physiological and pathophysiological roles ofAPN/CD13 and DPIV/CD26. Therefore we decided to invite some of them to contribute reviews of their results to this book. Having worked for about 40 years in the field of proteolysis, for both of us to see the development of activities and knowledge from protein chemistry and enzymology to physiology and pathophysiology and even to therapy is very stimulating and fascinating. Of course, this development also reflects the dramatic improvement and refinement of methods.
Dipeptidyl Aminopeptidases In Health And Disease
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Author : Martin Hildebrandt
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Dipeptidyl Aminopeptidases In Health And Disease written by Martin Hildebrandt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.
Cellular Peptidases In Immune Functions And Diseases
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Author : Siegfried Ansorge
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Cellular Peptidases In Immune Functions And Diseases written by Siegfried Ansorge and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Proceedings of an international conference held in Magdeburg, Germany, November 3-5, 1996
Cellular Peptidases In Immune Functions And Diseases 2
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Author : Jürgen Langner
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Cellular Peptidases In Immune Functions And Diseases 2 written by Jürgen Langner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.
Molecular And Cell Biology Of Membrane Proteins
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Author : Anthony John Turner
language : en
Publisher:
Release Date : 1990
Molecular And Cell Biology Of Membrane Proteins written by Anthony John Turner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Science categories.
Microcirculation
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Author : Ronald F. Tuma
language : en
Publisher: Academic Press
Release Date : 2011-04-28
Microcirculation written by Ronald F. Tuma and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume