Cell Transplantation For Neurological Disorders

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Cell Transplantation For Neurological Disorders
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Author : Thomas B. Freeman
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-05-29
Cell Transplantation For Neurological Disorders written by Thomas B. Freeman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-29 with Medical categories.
Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included.
Hematopoietic Stem Cell Transplantation For Neurologic Diseases
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-08-05
Hematopoietic Stem Cell Transplantation For Neurologic Diseases written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-05 with Medical categories.
Intense immunosuppression followed by Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT) has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis and many immune neuropathies. This volume summarizes that research. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to mew insights on the pathological mechanisms underlying CNS autoimmunity. - Reviews immunological mechanisms of HSCT and CNS autoimmunity - Identifies neurological diseases showing treatment efficacy with HSCT - Includes MS, myasthenia gravis, neuromyelitis optica, and more - Covers early and late side effects of HSCT
Cell Therapy For Neurological Disorders
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Author : Zhiguo Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-04
Cell Therapy For Neurological Disorders written by Zhiguo Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-04 with Science categories.
Gene Therapy In Neurological Disorders
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Author : Mingjie Li
language : en
Publisher: Academic Press
Release Date : 2018-05-25
Gene Therapy In Neurological Disorders written by Mingjie Li and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-25 with Medical categories.
Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system. - Provides background information and experimental details of gene therapy tools applied for neuroscience research and neurological disorders - Covers a broad range of gene delivery and regulation tools, therapeutic agents, and target cells, including emerging new technologies such as CRISPR/Cas9 genome editing - Discusses applications of gene therapy tools to neurological disorders including neurodegeneration, muscular dystrophy, trauma and chronic pain, and neoplastic diseases
Frontiers In Clinical Drug Research Cns And Neurological Disorders Volume 10
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Author : Atta-ur-Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2022-04-07
Frontiers In Clinical Drug Research Cns And Neurological Disorders Volume 10 written by Atta-ur-Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-07 with Science categories.
Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. Volume 10 of the series continues to present novel information about new and interesting approaches to treat common neurological disorders, with a focus on neurodegeneration and pain medicine. The volume presents 7 detailed reviews in total. - Neurodegenerative disease: prevention and treatment through plant extracts therapy - Emerging novel approaches and recent advances in Parkinson’s disease treatment and diagnosis - Neurotrophic factors to combat neurodegeneration - Neural bases of executive function in ADHD children as assessed using FNIRS - Modulation of mesenchymal stem cells, glial cells and the immune system by oligodeoxynucleotides as a novel multi-target therapeutic approach against chronic pain - Chronic pain: focus on anticonvulsants - A review of the impact of testosterone on brain and aging-related decline in brain behavioural function
Gene Therapy For Neurological Disorders
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Author : Pedro R. Lowenstein
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Gene Therapy For Neurological Disorders written by Pedro R. Lowenstein and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Coedited by internationally recognized leaders in gene therapy research, this guide supplies the most recent advances, studies, and expert opinion on gene therapy for neurological disorders. Spanning conditions such as Parkinsons's and Alzheimer's disease, multiple sclerosis, brain tumors, stroke, epilepsy, and brain and spinal cord trauma, this reference presents the basic science and applications of recombinant gene products, immune and stem cell-mediated therapeutic strategies, and brain tumor gene therapy.
Drug Induced Neurological Disorders
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Author : Kewal K. Jain
language : en
Publisher: Springer Nature
Release Date : 2021-07-13
Drug Induced Neurological Disorders written by Kewal K. Jain and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-13 with Medical categories.
This book is a first-of-its kind reference that systematically organizes and describes the adverse effects of drugs on the nervous system. Drug safety is recognized as an important aspect of pharmaceutical companies as well as practice of medicine. Chapters include case reports of adverse effects of drugs that are published as well as reported to drug manufacturers. The book scope is broad as it covers lack of efficacy, drug resistance, drug-disease and drug-drug interactions. This information is used to improve the use of drugs as well as to design better and safer drugs for the future, and is relevant to personalized medicine in trying to match the right drugs to the patients. Drug-induced Neurological Disorders offers a unique approach to this important topic by integrating clinical neurology with pharmacology with a focus on effects of drugs on the nervous system including those used for the treatment of neurological disorders as well systemic diseases. Many adverse effects involve multiple systems of the body and the syndromes with predominant effect on the nervous system are included in this book.
The Nervous System
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Author : Mayeen Uddin Khandaker
language : en
Publisher: Elsevier
Release Date : 2025-03-04
The Nervous System written by Mayeen Uddin Khandaker and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-04 with Science categories.
The series Stem Cell Innovation in Health and Disease is a timely and fascinating collection of information and new discoveries and provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. The Nervous System, Volume 5 addresses the recent data accumulated on the potential applications of stem cells to treat diseases and disorders of the nervous system. This volume will highlight the recent development of cutting edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to treat nervous system disorders and diseases. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. - Providess cutting-edge research to understand stem cell functions used in disease and disorder treatments of the nervous system - Develops processes to bring stem cells from bench to bedside - Includes up to date references on stem cell biology and function in common nervous system diseases and disorders
Chronic Graft Versus Host Disease
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Author : Georgia B. Vogelsang
language : en
Publisher: Cambridge University Press
Release Date : 2009-04-20
Chronic Graft Versus Host Disease written by Georgia B. Vogelsang and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-20 with Medical categories.
Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.
Paraneoplastic Neurologic Disorders
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-03-15
Paraneoplastic Neurologic Disorders written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-15 with Medical categories.
This book extensively reviews Paraneoplastic Neurological Syndromes in light of the most recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to causing diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. These two new developments have not been addressed in other volumes available on the market. Section 1 focuses on immunological defense mechanisms against tumors. Besides investigating the pathogenetic mechanisms of these disorders, this section will also explore what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy is teaching us in terms of immunopathogenesis. The second section will present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ and muscle. These chapters will, however, be preceded by an epidemiological analysis and a chapter describing the clinical approach to patients with these disorders. Consideration will also be given in specific chapters to general therapeutic strategies and the techniques used to search for diagnostically relevant autoantibodies. Presentation of the individual diseases will be followed by a third section investigating the role of antibody markers, presented in three chapters differentiating cytoplasmic, nuclear and neuronal cell surface reactivities. The innovative component of the final two sections compared to previously published volumes lies in their presentation of the profile of paraneoplastic diseases by tumor type. Special attention will be given to thymoma (involved particularly with novel antibodies against surface antigens), and neuroendocrine tumours, which are as yet comparatively unexplored in the literature. Lastly, a clinical update will be provided on gynecological, hematological and testicular malignancies. The last section will address side effects of the new immuno-oncological drugs increasingly used in cancer therapy. The high number of neurological complications that occur when tumor checkpoints are inhibited against immune defences provides the ideal experimental model for understanding the pathogenesis of these diseases. - Profiles paraneoplastic diseases by tumor type - Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis - Presents individual syndromes of the CNS, PNS, NMJ, and muscle - Investigates the role of antibody markers - Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities - Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS - Reviews therapeutic strategies and clinical approach to PNS patients