Paraneoplastic Neurologic Disorders
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Paraneoplastic Neurologic Disorders
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-03-15
Paraneoplastic Neurologic Disorders written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-15 with Medical categories.
This book extensively reviews Paraneoplastic Neurological Syndromes in light of the most recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to causing diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. These two new developments have not been addressed in other volumes available on the market. Section 1 focuses on immunological defense mechanisms against tumors. Besides investigating the pathogenetic mechanisms of these disorders, this section will also explore what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy is teaching us in terms of immunopathogenesis. The second section will present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ and muscle. These chapters will, however, be preceded by an epidemiological analysis and a chapter describing the clinical approach to patients with these disorders. Consideration will also be given in specific chapters to general therapeutic strategies and the techniques used to search for diagnostically relevant autoantibodies. Presentation of the individual diseases will be followed by a third section investigating the role of antibody markers, presented in three chapters differentiating cytoplasmic, nuclear and neuronal cell surface reactivities. The innovative component of the final two sections compared to previously published volumes lies in their presentation of the profile of paraneoplastic diseases by tumor type. Special attention will be given to thymoma (involved particularly with novel antibodies against surface antigens), and neuroendocrine tumours, which are as yet comparatively unexplored in the literature. Lastly, a clinical update will be provided on gynecological, hematological and testicular malignancies. The last section will address side effects of the new immuno-oncological drugs increasingly used in cancer therapy. The high number of neurological complications that occur when tumor checkpoints are inhibited against immune defences provides the ideal experimental model for understanding the pathogenesis of these diseases. Profiles paraneoplastic diseases by tumor type Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis Presents individual syndromes of the CNS, PNS, NMJ, and muscle Investigates the role of antibody markers Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS Reviews therapeutic strategies and clinical approach to PNS patients
Paraneoplastic Syndromes
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Author : Robert B. Darnell
language : en
Publisher: OUP USA
Release Date : 2011-08-22
Paraneoplastic Syndromes written by Robert B. Darnell and has been published by OUP USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-22 with Medical categories.
This text provides a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book provides an overview, classifying the disorders, describes a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general, and much more.
Peripheral Nerve Disorders
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Author : Haruki Koike
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-08-17
Peripheral Nerve Disorders written by Haruki Koike and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-17 with Medical categories.
Recent progress in serological screening of paraneoplastic antibodies and in diagnostic imaging techniques to detect malignancies has enabled a broadening of the concept of paraneoplastic neurological syndromes by integrating nonclassic clinical features. The peripheral nervous system is frequently involved in patients with paraneoplastic syndrome and may be seen alone or in combination with involvement of other areas of the nervous system. Destruction of dorsal root ganglion cells due to lymphocytic infiltration, especially with CD8-positive cytotoxic T cells, has been postulated to mediate the classic syndrome of subacute sensory neuronopathy. However, the motor and autonomic nervous systems are frequently affected. Indeed, patients can develop clinical features compatible with Guillain–Barré syndrome, chronic inflammatory demyelinating polyneuropathy, or brachial plexopathy. Other forms of paraneoplastic neuropathy are vasculitic neuropathy, autoimmune autonomic ganglionopathy, and chronic intestinal pseudo-obstruction. Various onconeural antibodies, including anti-Hu, anti-CV2/CRMP-5, and anti-ganglionic acetylcholine receptor antibodies, are associated with neuropathy. Somatic neuropathy is the most common manifestation in patients with anti-Hu and anti-CV2/CRMP-5 antibodies, while anti-ganglionic acetylcholine receptor antibody is associated with autonomic neuropathies. A whole-body fluorodeoxyglucose positron emission tomography scan may be useful to detect malignancy in patients with unremarkable conventional radiological findings. Recognition and diagnosis of paraneoplastic neuropathy is important, as neuropathic symptoms usually precede the identification of the primary tumor, and treatment at an earlier stage provides better chances of good outcomes.
Autoimmune Neurology
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Author :
language : en
Publisher: Elsevier
Release Date : 2016-03-11
Autoimmune Neurology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-11 with Science categories.
Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
Paraneoplastic Syndromes
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Author : Robert Darnell
language : en
Publisher:
Release Date : 2011
Paraneoplastic Syndromes written by Robert Darnell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Paraneoplastic syndromes categories.
This text provides a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book provides an overview, classifying the disorders, describes a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general, and much more.
Neurorheumatology
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Author : Tracey A. Cho
language : en
Publisher: Springer
Release Date : 2019-06-29
Neurorheumatology written by Tracey A. Cho and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-29 with Medical categories.
This detailed, practical textbook focuses on immune mediated disorders of the nervous system with particular focus on systemic autoimmune disorders. Divided into three sections, the first discusses the neuroanatomical and pathophysiologic basis of immune mediated disorders of the nervous system. Following this are 25 chapters devoted to individual clinical conditions. To conclude, the final section explains what is known about the mechanisms of immunomodulatory treatments and practical points about monitoring patients on these treatments. Neurorheumatology: A Comprehensive Guide to Immune Mediated Disorders of the Nervous System bridges the gaps among different branches of medicine and is an indispensable resource for rheumatologists and neurologists looking to develop a firm understanding of these dynamic disorders
Paraneoplastic Syndromes
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Author : Lora H. Winter
language : en
Publisher: Nova Science Publishers
Release Date : 2014
Paraneoplastic Syndromes written by Lora H. Winter and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Paraneoplastic syndromes categories.
Paraneoplastic Syndromes (PNS) are a group of disorders that cause endocrinologic, hematologic, neurologic, and dermatologic manifestations of cancer. These conditions are not directly caused by tumour metastasis, but rather the malignancies produce hormones and other proteins which act to disrupt the body's homeostasis, thereby causing symptoms. The neurological complications of PNS are the result of an immune response to tumour antigens. PNS have been associated with a variety of cancers, such as genitourinary, ovarian, and breast, but are most commonly associated with neuroendocrine tumours. These syndromes can even occur before the primary tumour is identified. Historically, these conditions were considered rare, but given the difficulties with diagnosis, the exact prevalence is unknown. This book focuses on the symptoms, diagnosis, and treatment of PNS. More specifically, it discusses current concepts in common PNS; cutaneous PNS and skin features of internal malignancy; PNS in patients with malignancies of the genitourinary tract; PNS polyneuropathies; the correction of cancer-related anemai with oxyresveratrol; and PNS associated with lung cancer.
Autoantibodies In Neurological Diseases
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Author : Angela Vincent
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Autoantibodies In Neurological Diseases written by Angela Vincent and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The book covers the immunological and clinical aspects of immune-mediated diseases of the central and peripheral nervous system, excluding multiple sclerosis. It includes paraneoplastic neurological disorders, and discusses the immune mechanisms in the growing number of recognised paraneoplastic conditions. It not only provides an overview of the field but also discusses the possible role of immunity in other neurological disorders such as epilepsy. Chapters are written by scientists and clinicians directly involved in each specific area, who have summarized the current understanding of neuroimmunology, with emphasis on the underlying abormalities of the immune responses, the different clinical expression of the diseases and the important use of immunotherapies in treatment. Figures and tables are included in each chapter.
Autoimmunity And The Brain Paraneoplastic Neurological Injury And Beyond
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Author : John Greenlee
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-07
Autoimmunity And The Brain Paraneoplastic Neurological Injury And Beyond written by John Greenlee and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-07 with Medical categories.
Paraneoplastic Syndromes
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Author : Lora H. Winter
language : en
Publisher:
Release Date : 2014-05-22
Paraneoplastic Syndromes written by Lora H. Winter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-22 with Electronic books categories.
Paraneoplastic Syndromes (PNS) are a group of disorders that cause endocrinologic, hematologic, neurologic, and dermatologic manifestations of cancer. These conditions are not directly caused by tumor metastasis, but rather the malignancies produce hormones and other proteins which act to disrupt the body's homeostasis, thereby causing symptoms. The neurological complications of PNS are the result of an immune response to tumor antigens. PNS have been associated with a variety of cancers, such as genitourinary, ovarian, and breast, but are most commonly associated with neuroendocrine tumors. These syndromes can even occur before the primary tumor is identified. Historically, these conditions were considered rare, but given the difficulties with diagnosis, the exact prevalence is unknown. This book focuses on the symptoms, diagnosis, and treatment of PNS. More specifically, it discusses current concepts in common PNS; cutaneous PNS and skin features of internal malignancy; PNS in patients with malignancies of the genitourinary tract; PNS polyneuropathies; the correction of cancer-related anemai with oxyresveratrol; and PNS associated with lung cancer.