Paraneoplastic Syndromes
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Paraneoplastic Syndromes
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Author : Robert B. Darnell
language : en
Publisher: OUP USA
Release Date : 2011-08-22
Paraneoplastic Syndromes written by Robert B. Darnell and has been published by OUP USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-22 with Medical categories.
This text provides a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book provides an overview, classifying the disorders, describes a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general, and much more.
Paraneoplastic Syndromes
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Author : Ursula Rüther
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1998
Paraneoplastic Syndromes written by Ursula Rüther and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
Paraneoplastic syndromes comprise a variety of signs and symptoms that are not directly caused by the primary tumor or its metastases. They may be metabolic, dystrophic or degenerative disorders resulting from remote humoral or hormonal effects, and spontaneously disappear after successful tumor excision or chemo- or radiotherapy. A few years ago, paraneoplastic syndromes were still thought to be rare. Today, we know that a single tumor is capable of producing a variety of hormones and that paraneoplastic syndromes are caused by this ectopic formation of hormones, hormone-like polypeptides, and growth factors. Recent research has shown that viral metabolic intermediates, mutated oncogenes, and suppressor genes may also be involved. The early diagnosis of a paraneoplastic syndrome is crucial, for it may point to an undetected tumor or signal tumor relapse. This book covers endocrinal, neurologic, muscular, cutaneous, hematologic and organ-associated paraneoplastic syndromes and provides a detailed description of their clinical symptoms, diagnosis and therapy. Aiming to promote the understanding of paraneoplastic syndromes, this volume is an indispensable source for their diagnosis and treatment in clinical oncology.
Paraneoplastic Syndromes
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Author : Lora H. Winter
language : en
Publisher:
Release Date : 2014-05-22
Paraneoplastic Syndromes written by Lora H. Winter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-22 with Electronic books categories.
Paraneoplastic Syndromes (PNS) are a group of disorders that cause endocrinologic, hematologic, neurologic, and dermatologic manifestations of cancer. These conditions are not directly caused by tumor metastasis, but rather the malignancies produce hormones and other proteins which act to disrupt the body's homeostasis, thereby causing symptoms. The neurological complications of PNS are the result of an immune response to tumor antigens. PNS have been associated with a variety of cancers, such as genitourinary, ovarian, and breast, but are most commonly associated with neuroendocrine tumors. These syndromes can even occur before the primary tumor is identified. Historically, these conditions were considered rare, but given the difficulties with diagnosis, the exact prevalence is unknown. This book focuses on the symptoms, diagnosis, and treatment of PNS. More specifically, it discusses current concepts in common PNS; cutaneous PNS and skin features of internal malignancy; PNS in patients with malignancies of the genitourinary tract; PNS polyneuropathies; the correction of cancer-related anemai with oxyresveratrol; and PNS associated with lung cancer.
Paraneoplastic Syndromes
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Author : Lora H. Winter
language : en
Publisher: Nova Science Publishers
Release Date : 2014
Paraneoplastic Syndromes written by Lora H. Winter and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Paraneoplastic syndromes categories.
Paraneoplastic Syndromes (PNS) are a group of disorders that cause endocrinologic, hematologic, neurologic, and dermatologic manifestations of cancer. These conditions are not directly caused by tumour metastasis, but rather the malignancies produce hormones and other proteins which act to disrupt the body's homeostasis, thereby causing symptoms. The neurological complications of PNS are the result of an immune response to tumour antigens. PNS have been associated with a variety of cancers, such as genitourinary, ovarian, and breast, but are most commonly associated with neuroendocrine tumours. These syndromes can even occur before the primary tumour is identified. Historically, these conditions were considered rare, but given the difficulties with diagnosis, the exact prevalence is unknown. This book focuses on the symptoms, diagnosis, and treatment of PNS. More specifically, it discusses current concepts in common PNS; cutaneous PNS and skin features of internal malignancy; PNS in patients with malignancies of the genitourinary tract; PNS polyneuropathies; the correction of cancer-related anemai with oxyresveratrol; and PNS associated with lung cancer.
Paraneoplastic Neurologic Disorders
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-03-15
Paraneoplastic Neurologic Disorders written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-15 with Medical categories.
This book extensively reviews Paraneoplastic Neurological Syndromes in light of the most recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to causing diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. These two new developments have not been addressed in other volumes available on the market. Section 1 focuses on immunological defense mechanisms against tumors. Besides investigating the pathogenetic mechanisms of these disorders, this section will also explore what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy is teaching us in terms of immunopathogenesis. The second section will present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ and muscle. These chapters will, however, be preceded by an epidemiological analysis and a chapter describing the clinical approach to patients with these disorders. Consideration will also be given in specific chapters to general therapeutic strategies and the techniques used to search for diagnostically relevant autoantibodies. Presentation of the individual diseases will be followed by a third section investigating the role of antibody markers, presented in three chapters differentiating cytoplasmic, nuclear and neuronal cell surface reactivities. The innovative component of the final two sections compared to previously published volumes lies in their presentation of the profile of paraneoplastic diseases by tumor type. Special attention will be given to thymoma (involved particularly with novel antibodies against surface antigens), and neuroendocrine tumours, which are as yet comparatively unexplored in the literature. Lastly, a clinical update will be provided on gynecological, hematological and testicular malignancies. The last section will address side effects of the new immuno-oncological drugs increasingly used in cancer therapy. The high number of neurological complications that occur when tumor checkpoints are inhibited against immune defences provides the ideal experimental model for understanding the pathogenesis of these diseases. Profiles paraneoplastic diseases by tumor type Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis Presents individual syndromes of the CNS, PNS, NMJ, and muscle Investigates the role of antibody markers Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS Reviews therapeutic strategies and clinical approach to PNS patients
Paraneoplastic Syndromes
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Author : Robert Darnell
language : en
Publisher:
Release Date : 2011
Paraneoplastic Syndromes written by Robert Darnell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Paraneoplastic syndromes categories.
This text provides a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book provides an overview, classifying the disorders, describes a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general, and much more.
Paraneoplasia
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Author : Jan Gösta Waldenström
language : en
Publisher: John Wiley & Sons
Release Date : 1978
Paraneoplasia written by Jan Gösta Waldenström and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Medical categories.
Paraneoplastic And Cancer Treatment Related Rheumatic Disorders
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Author : Kenneth J. Scalapino
language : en
Publisher: Clinics: Internal Medicine
Release Date : 2011
Paraneoplastic And Cancer Treatment Related Rheumatic Disorders written by Kenneth J. Scalapino and has been published by Clinics: Internal Medicine this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
This issue of Rheumatic Disease Clinics of North America provides foundational and in-depth information about paraneoplastic and cancer treatment-related rheumatic disorders, in which every practicing rheumatologist should be well-versed. Topics covered include neoplasm risk in patients with rheumatic diseases; neoplasm risk of anti-rheumatic therapy; rheumatologic laboratory findings in malignancy; rheumatic manifestations of primary and metastatic bone tumors and paraneoplastic bone disease; neoplastic/paraneoplastic synovitis; neoplastic/paraneoplastic dermatitis, fasciitis, and panniculitis; neoplastic/paraneoplastic vasculitis, vasculopathy, and hypercoagulability; neoplastic/paraneoplastic myalgias and myositis; and less-common neoplastic/paraneoplastic syndromes.
Pancreatic Cancer
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Author : Sanjay Srivastava
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-28
Pancreatic Cancer written by Sanjay Srivastava and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-28 with Medical categories.
This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.
Internal Malignancy And The Skin
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Author : Valencia D. Thomas
language : en
Publisher: W B Saunders Company
Release Date : 2007
Internal Malignancy And The Skin written by Valencia D. Thomas and has been published by W B Saunders Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
A wide variety of skin signs have been associated with internal malignancy. Cutaneous manifestations may develop before an internal neoplasm is recognized, and the skin findings can aid in diagnosis. In some cases the skin is infiltrated by malignant cells that represent metastatic or local spread from an internal malignancy. In other cases, the skin lesions are related to the underlying presence of malignancy, but they do not contain malignant cells. This issue of Dermatologic Clinics contains information on topics such as malignancy and cancer treatment-related hair and nail changes, tumor invasion of the skin, radiation therapy toxicity to the skin, and epidermal manifestations of internal malignancy.