Cellular And Molecular Mechanisms Of Aging In The Nervous System
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Cellular And Molecular Mechanisms Of Aging In The Nervous System
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Author : Adler Brown
language : en
Publisher: American Medical Publishers
Release Date : 2023-09-26
Cellular And Molecular Mechanisms Of Aging In The Nervous System written by Adler Brown and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
The nervous system is a highly complex network of nerves that coordinates actions and sensory information by transmitting signals to and from various parts of the body. Random molecular damage that steadily accumulates with age drives the ageing process at the cellular level. Many molecular mechanisms are involved and exogenous factors, like stress, also play a role in the aging process. The nervous system at the cellular level comprises a special cell called a neuron, which transmits signals to the other cells. Many physical, chemical, or biological changes in the status of neurons characterize brain aging. It is manifested in the form of deterioration in cognitive function and dementia. Dendritic regression in pyramidal neurons, synaptic atrophy, decrease of striatal dopamine receptors, accumulation of fluorescent pigments, cytoskeletal abnormalities, and reactive astrocytes and microglia are the common features of brain aging. The consequence of molecular and cellular alterations in brain aging is characterized by a plethora of anatomical changes, such as significant neuronal loss in hippocampus and neocortex. This book provides comprehensive insights on the molecular and cellular mechanisms of aging. The readers would gain knowledge that would broaden their perspective about this area of study.
The Aging Brain
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Author : Ezio Giacobini
language : en
Publisher: Raven Press (ID)
Release Date : 1982
The Aging Brain written by Ezio Giacobini and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Aging categories.
Cellular And Molecular Mechanisms Of Neurotrophin Function In The Nervous System
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Author : Pedro Bekinschtein
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-15
Cellular And Molecular Mechanisms Of Neurotrophin Function In The Nervous System written by Pedro Bekinschtein and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-15 with categories.
Aging And Age Related Disorders From Molecular Mechanisms To Therapies
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Author : Vladimir Titorenko
language : en
Publisher: MDPI
Release Date : 2019-08-19
Aging And Age Related Disorders From Molecular Mechanisms To Therapies written by Vladimir Titorenko and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-19 with Science categories.
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.
Models Molecules And Mechanisms In Biogerontology
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Author : Pramod C. Rath
language : en
Publisher:
Release Date : 2019
Models Molecules And Mechanisms In Biogerontology written by Pramod C. Rath and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Aging categories.
This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.
Molecular Aspects Of Development And Aging Of The Nervous System
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Author : Jean Lauder
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Molecular Aspects Of Development And Aging Of The Nervous System written by Jean Lauder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.
The rapidly expanding fields of molecular and cellular neurobiology are the newest frontiers of neuroscience. This book represents the continuing efforts of the Institute of Developmental Neuroscience and Aging (IDNA) to disseminate the most recent advances on the developing and aging nervous system at the molecular and cellular levels. A group of neuroscientists presented and discussed their findings at a recent IDNA conference held in Athens, Greece, June 15-18, 1988. This meeting was sponsored by the National Hellenic Research Foundation, FIDIA, the Ministry of Research and Technology, the Tourism Organization of Greece, and the National Institute of Child Health and Human Development, NIH. The Directors of the IDNA are grateful to the local committee, Drs. Eleni Fleischer, Costas Sekeris, Michael Alexis, Theony Valcana, and Elias Kouvelas, for their efforts in organizing this meeting and for their successful integration of science and culture for the participants. This volume provides a comprehensive overview of the information presented at this conference, including in-depth discussions of each topic by the participants. The chapters are grouped into five general categories which correspond to the subject areas covered during the meeting. These include: Gene and Phenotypic Expression, Growth Factors and Oncogenes, Cytoskeletal and Extracellular Molecules, Neurotransmitters and Hormones, and Molecular Aspects of Aging and Alzheimer's Disease. The section on Gene and Phenotypic Expression includes discussions of transient gene expression in the nervous system (Herschman), developmental regulation of myelin-associated genes (Gordon et al.
Cell Aging Molecular Mechanisms And Implications For Disease
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Author : Christian Behl
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-18
Cell Aging Molecular Mechanisms And Implications For Disease written by Christian Behl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-18 with Science categories.
Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.
The Nervous System
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Author : Charles Carter
language : en
Publisher:
Release Date : 2019-06-13
The Nervous System written by Charles Carter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-13 with categories.
The nervous system is an important system of the human body that coordinates its action by transmitting signals from one part of the body to another. It can be divided into the central and the peripheral nervous system. It consists of the brain, spinal cord and the nerves of the body. At the cellular level, the fundamental mechanism is that of the neuron, which transmits signals through axons that trigger the activation of neurotransmitters, which are then released at synapses. This signaling process involves a complicated molecular machinery, which allows the rapid electrical or chemical transmission of signals. Cells that receive a synaptic signal will be excited, inhibited or modulated. The organization of neural pathways, neural circuits and neural networks together build a functioning nervous system. Any abnormality in nervous function can manifest due to a genetic defect, infection, trauma, toxicity, or due to aging. This book provides comprehensive insights into the cellular and molecular basis of the working of the nervous system. It presents researches and studies performed by experts across the globe. It will serve as a reference to a broad spectrum of readers.
Textbook Of Neural Repair And Rehabilitation
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Author : Michael E. Selzer
language : en
Publisher: Cambridge University Press
Release Date : 2014
Textbook Of Neural Repair And Rehabilitation written by Michael E. Selzer and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Nervous system categories.
In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.
Handbook Of Neurochemistry And Molecular Neurobiology
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Author : Abel Lajtha
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-06-06
Handbook Of Neurochemistry And Molecular Neurobiology written by Abel Lajtha and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-06 with Medical categories.
The nervous system is highly fragile, especially during aging, illness and trauma. This book addresses a small sampling of major constituents of neural function at the cellular and molecular level that play crucial roles in development and aging.