Cell Aging Molecular Mechanisms And Implications For Disease
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Cell Aging Molecular Mechanisms And Implications For Disease
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Author : Christian Behl
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-18
Cell Aging Molecular Mechanisms And Implications For Disease written by Christian Behl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-18 with Science categories.
Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.
Aging And Age Related Disorders From Molecular Mechanisms To Therapies
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Author : Vladimir Titorenko
language : en
Publisher: MDPI
Release Date : 2019-08-19
Aging And Age Related Disorders From Molecular Mechanisms To Therapies written by Vladimir Titorenko and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-19 with Science categories.
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.
Molecular Mechanisms Of Adult Stem Cell Aging
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Author : K.L. Rudolph
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2010-04-22
Molecular Mechanisms Of Adult Stem Cell Aging written by K.L. Rudolph and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-22 with Medical categories.
There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field.The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis.Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology.
Molecular Mechanisms Of Aging
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Author : Konrad Beyreuther
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Mechanisms Of Aging written by Konrad Beyreuther and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Models Molecules And Mechanisms In Biogerontology
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Author : Pramod C. Rath
language : en
Publisher:
Release Date : 2019
Models Molecules And Mechanisms In Biogerontology written by Pramod C. Rath and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Aging categories.
This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.
Molecular Mechanisms Of Skin Aging And Age Related Diseases
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Author : Taihao Quan
language : en
Publisher: CRC Press
Release Date : 2016-04-21
Molecular Mechanisms Of Skin Aging And Age Related Diseases written by Taihao Quan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-21 with Medical categories.
Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes molecular understanding of the development of aging skin and its prevention as well as mechanisms-based clinical rejuvenation. The book also focuses on research to develop mechanisms-based anti-skin-aging products.
Telomeres And Telomerase In Aging Disease And Cancer
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Author : K. Lenhard Rudolph
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-07
Telomeres And Telomerase In Aging Disease And Cancer written by K. Lenhard Rudolph and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-07 with Medical categories.
Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.
Adult Stem Cells In Aging Diseases And Cancer
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Author : K.L. Rudolph
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2014-12-22
Adult Stem Cells In Aging Diseases And Cancer written by K.L. Rudolph and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-22 with Medical categories.
The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.
Molecular Cellular And Metabolic Fundamentals Of Human Aging
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Author : Evandro Fei Fang
language : en
Publisher: Academic Press
Release Date : 2022-10-23
Molecular Cellular And Metabolic Fundamentals Of Human Aging written by Evandro Fei Fang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-23 with Science categories.
Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology. Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer’s disease Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging Highlights recurring themes and key principles shared across the hallmarks of aging Considers NAD+ depletion and defective autophagy as emerging aspects that impact human aging
Aging And Age Related Disorders From Molecular Mechanisms To Therapies
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Author : Vladimir Titorenko
language : en
Publisher:
Release Date : 2019
Aging And Age Related Disorders From Molecular Mechanisms To Therapies written by Vladimir Titorenko and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson's, Alzheimer's, and Huntington's diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.