Molecular Mechanisms Of Skin Aging And Age Related Diseases
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Molecular Mechanisms Of Skin Aging And Age Related Diseases
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Author : Taihao Quan
language : en
Publisher: CRC Press
Release Date : 2016-04-21
Molecular Mechanisms Of Skin Aging And Age Related Diseases written by Taihao Quan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-21 with Medical categories.
Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes molecular understanding of the development of aging skin and its prevention as well as mechanisms-based clinical rejuvenation. The book also focuses on research to develop mechanisms-based anti-skin-aging products.
Molecular Mechanisms Of The Aging Process And Rejuvenation
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Author : Naofumi Shiomi
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-08-31
Molecular Mechanisms Of The Aging Process And Rejuvenation written by Naofumi Shiomi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-31 with Medical categories.
Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.
Molecular Basis For The Aging Of Human Skin
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Author : Taihao Quan
language : en
Publisher:
Release Date : 2017
Molecular Basis For The Aging Of Human Skin written by Taihao Quan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Skin categories.
Skin is the most voluminous connective tissue of the body. Skin, like all other human organs, undergoes progressive alterations as a consequence of the passage of time (natural aging). However, human skin, unlike other organs, continuously experiences harmful exposure from environmental sources such as solar ultraviolet irradiation (photoaging). As the bulk of the skin is largely comprised of connective tissue collagen, the primary molecular features of aged human skin are reduced production of collagen and accumulation of damaged collagen. Age-related alterations of dermal connective collagen cause an aberrant tissue microenvironment, which deleteriously influence the risk of developing age-related skin diseases. This book comprehensively describes the molecular mechanisms of human skin connective tissue aging by emphasizing age-related dermal microenvironment as a strategy for improving our quality of life as well as for preventive and therapeutic intervention of age-related skin diseases. This book is an essential resource for the development of mechanisms-based anti-skin aging products.
Cell Aging Molecular Mechanisms And Implications For Disease
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Author : Christian Behl
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-18
Cell Aging Molecular Mechanisms And Implications For Disease written by Christian Behl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-18 with Science categories.
Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.
Skin Aging
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Author : Barbara A. Gilchrest
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-20
Skin Aging written by Barbara A. Gilchrest and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-20 with Medical categories.
The topic of skin aging is of growing importance to all working in the field of dermatology, aesthetic medicine and cosmetic medicine. Two internationally well-known and leading experts in the field present a comprehensive state-of-the-art review on all aspects of skin aging. With its clear, concise and reader-friendly format this book has all the potential to become the Bible of skin aging. Every specialist interested in dermatology, aesthetic medicine, cosmetic science, cutaneous biology and aging research will find indispensable information of great value for his or her daily work.
Molecular Mechanisms Of Aging
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Author : Konrad Beyreuther
language : en
Publisher: Springer
Release Date : 1990-07-23
Molecular Mechanisms Of Aging written by Konrad Beyreuther and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-07-23 with Medical categories.
A high-level text on the molecular and genetic aspects of human ageing with reference to cognitive functions and age-related diseases."
The Molecular Basis For The Aging Of Human Skin
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Author : Taihao Quan
language : en
Publisher:
Release Date : 2017
The Molecular Basis For The Aging Of Human Skin written by Taihao Quan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.
Skin is the most voluminous connective tissue of the body. Skin, like all other human organs, undergoes progressive alterations as a consequence of the passage of time (natural aging). However, human skin, unlike other organs, continuously experiences harmful exposure from environmental sources such as solar ultraviolet irradiation (photoaging). As the bulk of the skin is largely comprised of connective tissue collagen, the primary molecular features of aged human skin are reduced production of collagen and accumulation of damaged collagen. Age-related alterations of dermal connective collagen cause an aberrant tissue microenvironment, which deleteriously influence the risk of developing age-related skin diseases. This book comprehensively describes the molecular mechanisms of human skin connective tissue aging by emphasizing age-related dermal microenvironment as a strategy for improving our quality of life as well as for preventive and therapeutic intervention of age-related skin diseases. This book is an essential resource for the development of mechanisms-based anti-skin aging products.
Molecular Mechanisms Of Skin Aging And Rejuvenation
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Author : Miri Kim
language : en
Publisher:
Release Date : 2016
Molecular Mechanisms Of Skin Aging And Rejuvenation written by Miri Kim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medicine categories.
The aging process in the skin is complex and influenced by more intrinsic and extrinsic factors than any other body organ. The effects of these two types of factors overlap for the most part. The combined effects of these two aging processes also affect dermal matrix alterations. The main clinical signs of skin aging include wrinkling and irregular pigmentation, which are influenced by a combination of intrinsic and extrinsic (e.g., UV radiation, heat, smoking, and pollutants) factors. Histologically, collagen decreases, and the dermis is replaced by abnormal elastic fibers as a cause of wrinkle formation through the loss of skin elasticity. There have been numerous studies of skin aging performed to elucidate the underlying molecular mechanisms and to develop various antiaging therapeutics and preventive strategies. We summarized the molecular mechanisms and treatments of skin aging. Mainly UV radiation induces ROS formation and DNA damage, leading to increased production of MMPs and decreased production of collagen in keratinocytes and fibroblasts, which reflect the central aspects of skin aging. Besides UV radiation exposure, extrinsic factors including tobacco smoking, exposure to environmental pollutants, infrared radiation, and heat contribute to premature skin aging. Like UV radiation, these factors cause ROS formation and increase expression of MMPs, thus accelerating skin aging by inducing extracellular matrix (ECM) degradation. Accumulated collagen fibrils inhibit the new collagen synthesis and account for the further degradation of the ECM through this positive feedback loop. Accumulating evidence for molecular mechanisms of skin aging should provide clinicians with an expanding spectrum of therapeutic targets in the treatment of skin aging.
Models Molecules And Mechanisms In Biogerontology
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Author : Pramod C. Rath
language : en
Publisher:
Release Date : 2019
Models Molecules And Mechanisms In Biogerontology written by Pramod C. Rath and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Aging categories.
This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.
Molecular Cellular And Metabolic Fundamentals Of Human Aging
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Author : Evandro Fei Fang
language : en
Publisher: Academic Press
Release Date : 2022-10-23
Molecular Cellular And Metabolic Fundamentals Of Human Aging written by Evandro Fei Fang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-23 with Science categories.
Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology. Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer’s disease Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging Highlights recurring themes and key principles shared across the hallmarks of aging Considers NAD+ depletion and defective autophagy as emerging aspects that impact human aging