Molecular Mechanisms Of Aging
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Molecular Mechanisms Of Aging
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Author : Konrad Beyreuther
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Mechanisms Of Aging written by Konrad Beyreuther and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Aging And Age Related Disorders From Molecular Mechanisms To Therapies
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Author : Vladimir Titorenko
language : en
Publisher: MDPI
Release Date : 2019-08-19
Aging And Age Related Disorders From Molecular Mechanisms To Therapies written by Vladimir Titorenko and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-19 with Science categories.
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.
Cell Aging Molecular Mechanisms And Implications For Disease
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Author : Christian Behl
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-18
Cell Aging Molecular Mechanisms And Implications For Disease written by Christian Behl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-18 with Science categories.
Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.
Molecular Mechanisms Of The Aging Process And Rejuvenation
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Author : Naofumi Shiomi
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-08-31
Molecular Mechanisms Of The Aging Process And Rejuvenation written by Naofumi Shiomi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-31 with Medical categories.
Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.
Cellular And Molecular Mechanisms Of Aging In The Nervous System
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Author : Adler Brown
language : en
Publisher: American Medical Publishers
Release Date : 2023-09-26
Cellular And Molecular Mechanisms Of Aging In The Nervous System written by Adler Brown and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
The nervous system is a highly complex network of nerves that coordinates actions and sensory information by transmitting signals to and from various parts of the body. Random molecular damage that steadily accumulates with age drives the ageing process at the cellular level. Many molecular mechanisms are involved and exogenous factors, like stress, also play a role in the aging process. The nervous system at the cellular level comprises a special cell called a neuron, which transmits signals to the other cells. Many physical, chemical, or biological changes in the status of neurons characterize brain aging. It is manifested in the form of deterioration in cognitive function and dementia. Dendritic regression in pyramidal neurons, synaptic atrophy, decrease of striatal dopamine receptors, accumulation of fluorescent pigments, cytoskeletal abnormalities, and reactive astrocytes and microglia are the common features of brain aging. The consequence of molecular and cellular alterations in brain aging is characterized by a plethora of anatomical changes, such as significant neuronal loss in hippocampus and neocortex. This book provides comprehensive insights on the molecular and cellular mechanisms of aging. The readers would gain knowledge that would broaden their perspective about this area of study.
Molecular Mechanisms Of Skin Aging And Age Related Diseases
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Author : Taihao Quan
language : en
Publisher: CRC Press
Release Date : 2016-04-21
Molecular Mechanisms Of Skin Aging And Age Related Diseases written by Taihao Quan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-21 with Medical categories.
Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes molecular understanding of the development of aging skin and its prevention as well as mechanisms-based clinical rejuvenation. The book also focuses on research to develop mechanisms-based anti-skin-aging products.
The Aging Brain
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Author : Ezio Giacobini
language : en
Publisher: Raven Press (ID)
Release Date : 1982
The Aging Brain written by Ezio Giacobini and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Aging categories.
Molecular Mechanisms Of Adult Stem Cell Aging
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Author : K.L. Rudolph
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2010-04-22
Molecular Mechanisms Of Adult Stem Cell Aging written by K.L. Rudolph and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-22 with Medical categories.
There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field.The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis.Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology.
Models Molecules And Mechanisms In Biogerontology
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Author : Pramod C. Rath
language : en
Publisher:
Release Date : 2019
Models Molecules And Mechanisms In Biogerontology written by Pramod C. Rath and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Aging categories.
This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.
Aging And Age Related Disorders From Molecular Mechanisms To Therapies
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Author : Vladimir Titorenko
language : en
Publisher:
Release Date : 2019
Aging And Age Related Disorders From Molecular Mechanisms To Therapies written by Vladimir Titorenko and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson's, Alzheimer's, and Huntington's diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.