Cellular Immune Mechanisms And Tumor Dormancy
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Cellular Immune Mechanisms And Tumor Dormancy
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Author : T. H. M. Stewart
language : en
Publisher: CRC Press
Release Date : 2017-07-28
Cellular Immune Mechanisms And Tumor Dormancy written by T. H. M. Stewart and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-28 with Medical categories.
Cellular Immune Mechanisms and Tumor Dormancy features the work of internationally recognized experts from various disciplines as they discuss the phenomenon of tumor dormancy in humans. Animal models are described in which cellular and molecular components of the immune control of dormancy have been identified, and the relevance of these models to human cancer patients is recognized. Data derived from studies of organ transplantation, adjuvant chemotherapy, radiotherapy, anaesthesia, surgery, and whole blood transfusion is presented to show the vulnerability of cellular mechanisms maintaining dormancy. The potential for increasing the incidence of dormancy in micro metastases is also shown for non-small cell lung cancer, lymphoma, and leukemia. Cellular Immune Mechanisms and Tumor Dormancy is an important reference volume that will benefit researchers from many disciplines, including immunologists, pathologists, surgeons, and clinicians
Systems Biology Of Tumor Dormancy
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Author : Heiko Enderling
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-09
Systems Biology Of Tumor Dormancy written by Heiko Enderling and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-09 with Science categories.
This volume is based on the Workshop on Systems Biology of Tumor Dormancy meeting, held July 25th to July 28th, 2011. The first annual CCSB workshop brought together biologists, clinicians, mathematicians, and computer scientists to discuss various aspects of tumor dormancy and develop novel mathematical/computational models with the keynote speakers. Specific topics included the angiogenic switch, immune system interactions, cancer stem cells and signaling.
Breast Cancer
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Author : W.P. Peters
language : en
Publisher: Elsevier
Release Date : 1998-08-25
Breast Cancer written by W.P. Peters and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-25 with Medical categories.
Breast cancer research has never been in such an exciting and hopeful phase as today. From a clinical perspective, the discovery of genetic markers of risk in a proportion of familial breast cancer cases has opened up new vistas for understanding and ultimately preventing this disease. On the other hand, aggressive - even daring - therapies are being proven to be effective against advanced breast cancer. For the breast cancer experimentalist, this is also a time of great advance. Although animal and cell culture breast cancer models have proven to be of great use, there are now increasing opportunities to test the concepts developed in these models in actual clinical samples and cases. It is gratifying to see how well these concepts "translate" into the clinical setting. A very active area of research that is linking the laboratory to the clinic is the dissection of the biology and elucidation of the significance of proliferate breast disease and the identification of true, "high risk" or "preneoplastic" legions within the previously ill-defined spectrum of fibrocystic or benign breast disease. One anticipates that discoveries made here will also lead to earlier detection, intervention and prevention of life-threatening cancer.Even, however, as we look with optimism to the eventual eradication of breast cancer, we are once again forced to face the reality that we have not yet achieved our goal. Thus, we are saddened by the much too premature death of Dr. Helene Smith from breast cancer. Helena's work was at the forefront of efforts to understand the biology of human breast cancer at the molecular level. Her insight, open-mindedness, and refusal to sacrifice relevance for convenience will continue to set the standard for all breast cancer researchers. This volume is dedicated to her memory.
Cell Therapy
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Author : George Morstyn
language : en
Publisher: Cambridge University Press
Release Date : 1996-03-29
Cell Therapy written by George Morstyn and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-03-29 with Medical categories.
Cell therapy is a rapidly developing area, drawing on cell biology, molecular biology, virology, immunology, cell quantitation techniques and biomedical engineering. It has potential in many clinical settings, in the treatment of cancer and other diseases. This volume in the series Cancer: Clinical Science in Practice examines the current state and future prospects of cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of haematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy. Up-to-date and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.
Revisiting Seed And Soil A New Approach To Target Hibernating Dormant Tumor Cells 2nd Edition
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Author : Dalit Barkan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-07
Revisiting Seed And Soil A New Approach To Target Hibernating Dormant Tumor Cells 2nd Edition written by Dalit Barkan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-07 with Medical categories.
Metastasis is the major cause of mortality in cancer patients. Metastases can be present at the time of diagnosis or can occur years or decades after the removal of the primary tumor and treatment. This long latency in the manifestation of recurrent metastatic disease is explained clinically by the persistence of quiescent tumor cells that disseminated early in the course of the disease from the primary tumor to select distant organs. These residing disseminated tumor cells (DTCs) at distant organs lay dormant and asymptomatic until reawakened to form overt metastases. Importantly, the quiescent nature of these “hibernating” DTCs facilitates their resistance to conventional therapies that target actively dividing tumor cells. Therefore, unraveling the biology of dormancy and reactivation of the residing DTCs to life-threatening lesions is of utmost importance in order to develop new therapeutic strategies to prevent the recurrent metastatic disease from ever emerging or to better treat these recurrent cancers. The mechanisms underlying the biology of tumor dormancy and their reactivation to overt metastases are just beginning to emerge thanks to a growing appreciation of the potentially chronic nature of some cancers and the development of experimental model systems for their study. In this Research Topic, we will follow the journey of circulating tumor cells (CTCs) dispatching from the primary site until their successful lodging into a new and foreign site to become DTCs. We will explore the intrinsic mechanisms along with microenvironmental cues and niches that they encounter during their journey that may dictate their fate.
Cancer Stem Cells And Their Role In Tumor Dormancy And Immunosurveillance
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Author : Cristina Maccalli
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-08
Cancer Stem Cells And Their Role In Tumor Dormancy And Immunosurveillance written by Cristina Maccalli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-08 with Medical categories.
Tumor Dormancy Quiescence And Senescence Volume 2
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Author : M.A. Hayat
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-29
Tumor Dormancy Quiescence And Senescence Volume 2 written by M.A. Hayat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-29 with Science categories.
In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.
Paradoxes In Immunology
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Author : Geoffrey W. Hoffman
language : en
Publisher: CRC Press
Release Date : 2019-08-15
Paradoxes In Immunology written by Geoffrey W. Hoffman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-15 with Health & Fitness categories.
First published in 1986: Paradoxes play a key role in the advancement of science. They are associated with excitement, and with the knowledge that we must be looking at something the wrong way. This book discusses in detail Paradoxes in Immunology.
Tumor Dormancy And Recurrence
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Author : Yuzhuo Wang
language : en
Publisher: Humana Press
Release Date : 2017-08-31
Tumor Dormancy And Recurrence written by Yuzhuo Wang and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-31 with Medical categories.
This volume will be the first to provide a comprehensive description of tumor dormancy. It will define the clinical and biological aspects of this phenomenon, as well as the cellular and molecular mechanisms associated with tumor dormancy. Chapters will be authored by world-renewed experts who are conducting cutting-edge research in the field. A unique feature will be a conclusive paragraph detailing future development and foreseeable clinical applications at the end of each chapter. The volume will serve as a fundamental instrument for every researcher and clinician interested in the field of tumor dormancy as well as a means of disseminating stimulating concepts and prompting the development of innovative technological solutions.
Tumor Dormancy Quiescence And Senescence Vol 3
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Author : M.A. Hayat
language : en
Publisher: Springer
Release Date : 2014-09-12
Tumor Dormancy Quiescence And Senescence Vol 3 written by M.A. Hayat and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-12 with Science categories.
This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.