Cellular Senescence Age Related Disorders And Emerging Treatments
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Cellular Senescence Age Related Disorders And Emerging Treatments
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Author : Imteyaz Qamar
language : en
Publisher: Springer Nature
Release Date : 2025-02-07
Cellular Senescence Age Related Disorders And Emerging Treatments written by Imteyaz Qamar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-07 with Medical categories.
This book provides a comprehensive understanding of cellular senescence, which is a phenomenon, characterized by the irreversible arrest of cell growth and is accompanied by the secretion of various factors, collectively known as the senescence-associated secretory phenotype (SASP), which can have detrimental effects on surrounding cells and tissues. The book examines the role of cellular senescence as a driver of age-related disorders such as cancer, neurodegenerative diseases, cardiovascular conditions, and metabolic disorders. By elucidating the molecular mechanisms involved, the book aims to deepen our understanding of these complex diseases and identify potential therapeutic targets. The book also explores cutting-edge therapeutic modalities that target cellular senescence, ranging from small molecule inhibitors to gene-based therapies and regenerative approaches. The distinctive features of the book include its comprehensive approach, integration of multidisciplinary expertise, in-depth exploration of therapeutic modalities, evidence-based insights supported by scientific research, and a translational focus. The interdisciplinary collaboration ensures a holistic understanding of the subject matter, fostering a synergistic approach to addressing age-related disorders. The book not only discusses the potential of emerging therapeutic modalities but also emphasizes practical implications, providing a bridge between research and real-world applications. This book is useful to researchers, scientists, and academics in the fields of molecular biology, genetics, gerontology, and cellular biology.
Innovative Medicine
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Author : Kazuwa Nakao
language : en
Publisher: Springer
Release Date : 2015-10-13
Innovative Medicine written by Kazuwa Nakao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-13 with Science categories.
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Aging Mechanisms
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Author : Nozomu Mori
language : en
Publisher: Springer
Release Date : 2015-11-26
Aging Mechanisms written by Nozomu Mori and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-26 with Medical categories.
This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes. Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.
Emerging Therapies In Periodontics
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Author : Sinem Esra Sahingur
language : en
Publisher: Springer Nature
Release Date : 2020-06-03
Emerging Therapies In Periodontics written by Sinem Esra Sahingur and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-03 with Medical categories.
This book equips dental care providers with a thorough understanding of the emerging therapies that promise to revolutionize the clinical management of periodontal diseases. Existing therapies targeted to the oral microbiome alone often fail to provide favorable clinical outcomes. Local inflammation and tissue destruction may persist and periodontal tissue regeneration is not predictably achieved. In recognition of these shortcomings, current research efforts are focused on understanding the biological interactions between the host and the resident microbiome and identifying key molecules and molecular pathways that can be used for more targeted, individualized therapies that will restrain oral inflammation and restore periodontal tissue homeostasis. This book introduces novel concepts and molecules that are currently being tested in preclinical and clinical models. Readers will find detailed information from leading experts on specific therapeutic strategies targeting the host immune and inflammatory system, the oral microbiome, and regeneration.
Physiological Basis Of Aging And Geriatrics
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Author : Paola S. Timiras
language : en
Publisher: CRC Press
Release Date : 2007-08-16
Physiological Basis Of Aging And Geriatrics written by Paola S. Timiras and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-16 with Medical categories.
Extensively revised and updated to reflect the current state of knowledge in the study of aging, this Fourth Edition offers a complete profile of the aging process at all levels, from molecules and cells to demography and evolution. Written by international experts in current basic and clinical aging research, this text includes aspects of individual, comparative, and differential aging, and discussions of theories and mechanisms of aging. This invaluable reference illustrates how bodily systems, organs, and functions are affected with aging, describes how genetic and environmental factors influence age-related changes, and addresses some of the clinical consequences of these changes for health and longevity. Well illustrated, with numerous tables and graphs, this book presents up-to-date information from internationally renowned experts in various bio-medical fields.
Mechanisms And Management Of Senescence
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2022-09-14
Mechanisms And Management Of Senescence written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-14 with Psychology categories.
Senescence represents a complex universal phenomenon that can be impacted by several factors. It is emerging as a therapeutic target for several diseases. This book presents an overview of the current mechanisms and management of senescence in humans. It also provides comparative data on senescence in animals and plants.
Epigenetics Of Aging
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Author : Trygve O. Tollefsbol
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-11-11
Epigenetics Of Aging written by Trygve O. Tollefsbol and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-11 with Medical categories.
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Aging Interventions And Therapies
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Author : Suresh I S Rattan
language : en
Publisher: World Scientific
Release Date : 2005-05-06
Aging Interventions And Therapies written by Suresh I S Rattan and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-06 with Science categories.
This comprehensive volume surveys the molecular, cellular, hormonal, nutritional, medical and lifestyle strategies being tested and applied for the prevention, intervention and treatment of age-related diseases. With authoritative contributions not just from researchers in academic institutions and pharmaceutical and cosmeceutical industries, but also practicing clinicians of both mainstream and alternative medicine, demographers and bioethicists, this book provides unique scientific, ethical and social perspectives on the discussion of aging intervention. In addition, the latest technologies in development, which will have serious bearings on future aging interventions, are reviewed.Aging Interventions and Therapies is ideal for graduates and undergraduates in universities and medical and nursing colleges, as well as post-graduates researching different aspects of aging and anti-aging. The topics covered are also highly relevant for professionals in the pharmaceutical, cosmeceutical, nutrition and healthcare industries, and practicing clinicians looking for a reliable and up-to-date resource on aging intervention and therapy.
New Progress In Understanding And Treatment Of Osteoporosis
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Author : Zhiyong Hou
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-17
New Progress In Understanding And Treatment Of Osteoporosis written by Zhiyong Hou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-17 with Medical categories.
New Trends In Vascular Inflammation Research From Biology To Therapy
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Author : Masanori Aikawa
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-17
New Trends In Vascular Inflammation Research From Biology To Therapy written by Masanori Aikawa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-17 with categories.