Central Functions Of The Ghrelin Receptor
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Central Functions Of The Ghrelin Receptor
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Author : Jeanelle Portelli
language : en
Publisher:
Release Date : 2014-06-30
Central Functions Of The Ghrelin Receptor written by Jeanelle Portelli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-30 with categories.
The Ghrelin Receptor Gene In Animal Production
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Author : Yuki Fujimori
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2019-10-11
The Ghrelin Receptor Gene In Animal Production written by Yuki Fujimori and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-11 with Science categories.
Ghrelin and the ghrelin receptor (GHSR1a) play a central role in growth hormone secretion, food intake, energy metabolism, and other important functions. This book summarizes the present situation of the GHSR1a gene polymorphisms and their genetic effects on growth and fatty acid component traits in domestic animals, humans and rodents. It highlights a unique molecular evolution of the GHSR1a gene among animal species, and its significant genetic and epistatic effects on carcass and fatty acid component traits in a sex-dependent fashion. The volume also shows the overdominance effect of the GHSR1a-DelR242 locus on growth and its molecular mechanisms and the central role of the bovine GHSR1a_5’UTR-(TG) repeat locus in growth and fatty acid component traits in cattle.
Ghrelin In Health And Disease
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Author : Roy G. Smith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-19
Ghrelin In Health And Disease written by Roy G. Smith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-19 with Medical categories.
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
Central Functions Of The Ghrelin Receptor
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Author : Jeanelle Portelli
language : en
Publisher: Springer
Release Date : 2014-05-15
Central Functions Of The Ghrelin Receptor written by Jeanelle Portelli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-15 with Medical categories.
The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson’s disease, epilepsy, anxiety and depression.
The Structure And Function Of The Human Ghrelin Receptor
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Author : Rachel Kendrick
language : en
Publisher:
Release Date : 2011
The Structure And Function Of The Human Ghrelin Receptor written by Rachel Kendrick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
The Ghrelin System
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Author : A. Benso
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2013-04-22
The Ghrelin System written by A. Benso and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-22 with Medical categories.
The ghrelin story started more than 30 years ago with the discovery of synthetic GH secretagogues. Only in 1999 was ghrelin a natural GH-releasing peptide, discovered. Ghrelin, however, is much more than simply a natural GH secretagogue. In fact, this hormone is one of the most important factors known for regulating appetite and energy expenditure. Furthermore, ghrelin is the trigger for other neuroendocrine, metabolic and nonendocrine actions.This book, written by researchers who provided the major contributions to our current knowledge of this complex system, gives a comprehensive overview of the recent advances in ghrelin research. The hormone's influence on the cardiovascular, metabolic and gastroenteropancreatic system, hypothalamus-pituitary-adrenal axis, prolactin secretion, thyroid axis, gonadal axis as well as on behavior is discussed in detail. Furthermore, the clinical perspectives for ghrelin-derived therapeutic products are presented.Illustrating the tight inter-relationship between endocrinology, metabolism, cardiovascular disease and internal medicine, this book is essential reading for all scientists interested in appetite control, body weight and energy expenditure, as well as diabetes mellitus and neuroendocrinology.
Gut Hormones
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Author : Stephen Robert Bloom
language : en
Publisher:
Release Date : 1981
Gut Hormones written by Stephen Robert Bloom and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Gastrointestinal hormones categories.
Developmental Biology Of Gastrointestinal Hormones
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Author : M. Wabitsch
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2017-08-16
Developmental Biology Of Gastrointestinal Hormones written by M. Wabitsch and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with Medical categories.
The gut not only represents the largest endocrine organ of the human body but is also profoundly involved in the control of metabolism through peptide hormones. Therefore, gastrointestinal hormones are acting via autocrine, paracrine, and classical endocrine pathways and regulate e.g. digestion, hunger, and satiety. Furthermore, they are important regulators of body weight, growth, and glucose metabolism, as well as of mood and behavior. Physicians and scientists in the field of pediatric endocrinology and diabetes, as well as in pediatric gastroenterology, require an extensive understanding of the origin of enteroendocrine cells, factors controlling their differentiation, hormone gene expression, secretion, function and, finally, the complex interaction with other organs, especially the central nervous system. In order to meet these needs, experts in the field have written up-to-date, comprehensive, and illustrated reviews presenting the current knowledge in the field of gastrointestinal endocrinology with a pediatric view. Those reviews comprise this latest volume of Endocrine Development.
Handbook Of Biologically Active Peptides
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Author : Abba Kastin
language : en
Publisher: Elsevier
Release Date : 2011-04-28
Handbook Of Biologically Active Peptides written by Abba Kastin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Orphan G Protein Coupled Receptors And Novel Neuropeptides
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Author : Olivier Civelli
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-15
Orphan G Protein Coupled Receptors And Novel Neuropeptides written by Olivier Civelli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-15 with Science categories.
Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms. The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.