Challenges And Issues In High Throughput Screening
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Challenges And Issues In High Throughput Screening
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Author : G. K. Dixon
language : en
Publisher: Taylor & Francis
Release Date : 1998
Challenges And Issues In High Throughput Screening written by G. K. Dixon and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Agricultural chemicals categories.
Comprises of papers presented at the 'New Challenges Arising from High Throughput Screening' conference held in Manchester, July 1997; ; Discusses a technique of key importance in many pharmaceutical companies; ; Reveals all the latest developments to all
Optimal High Throughput Screening
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Author : Xiaohua Douglas Zhang
language : en
Publisher: Cambridge University Press
Release Date : 2011-02-21
Optimal High Throughput Screening written by Xiaohua Douglas Zhang and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-21 with Medical categories.
This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.
Next Steps For Functional Genomics
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2020-12-18
Next Steps For Functional Genomics written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-18 with Science categories.
One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.
High Throughput Screening
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Author : John P. Devlin
language : en
Publisher: CRC Press
Release Date : 1997-05-06
High Throughput Screening written by John P. Devlin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-06 with Science categories.
Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.
High Throughput Screening Methods
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Author : Joshua A. Bittker
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016-12-08
High Throughput Screening Methods written by Joshua A. Bittker and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-08 with Medical categories.
High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.
Targeting Ion Channels For Drug Discovery Emerging Challenges For High Throughput Screening Technologies
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Author : Ciria Hernandez
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-07
Targeting Ion Channels For Drug Discovery Emerging Challenges For High Throughput Screening Technologies written by Ciria Hernandez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-07 with Science categories.
Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell membrane allowing ion flow from one side of the membrane to the other. They are ubiquitously expressed in human tissues and consist of one of the largest and best understood functional groups of proteins, with more than 400 members spanning nearly 1% of the human genome. They are involved in a variety of fundamental physiological processes, and their malfunction causes numerous diseases. In terms of the challenges faced in the effort to discover specific drugs in ancient and emerging diseases, ion channels are the third-largest class of target proteins after G-protein-coupled receptors (GPCRs) and kinases. 15% of small molecule drug targets have been reported to be voltage- or ligand-gated ion channels, resulting in approximately 150 new drug candidates in preclinical and clinical studies. Of the ion channel targeting drugs found on the market, these were identified more than a decade ago, and many of the current studies are at various stages of scientific approval. Overcoming these challenges has led the field of ion channel drug discovery to transform over the past 15 years through major advancements in genetic target detection, validation, structure-based drug design, and drug modeling of cell-based diseases.
Drug Discovery And Development
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Author : Omboon Vallisuta
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-06-03
Drug Discovery And Development written by Omboon Vallisuta and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-03 with Medical categories.
It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.
High Throughput Screening In Drug Discovery
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Author : Jörg Hüser
language : en
Publisher: John Wiley & Sons
Release Date : 2006-12-13
High Throughput Screening In Drug Discovery written by Jörg Hüser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Science categories.
Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.
High Throughput Screening For Food Safety Assessment
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Author : Arun K. Bhunia
language : en
Publisher: Elsevier
Release Date : 2014-09-06
High Throughput Screening For Food Safety Assessment written by Arun K. Bhunia and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-06 with Technology & Engineering categories.
Recent advances in array-based detectors and imaging technologies have provided high throughput systems that can operate within a substantially reduced timeframe and other techniques that can detect multiple contaminants at one time. These technologies are revolutionary in terms of food safety assessment in manufacturing, and will also have a significant impact on areas such as public health and food defence. This book summarizes the latest research and applications of sensor technologies for online and high throughput screening of food. The book first introduces high throughput screening strategies and technology platforms, and discusses key issues in sample collection and preparation. The subsequent chapters are then grouped into four sections: Part I reviews biorecognition techniques; Part II covers the use of optical biosensors and hyperspectral imaging in food safety assessment; Part III focuses on electrochemical and mass-based transducers; and finally Part IV deals with the application of these safety assessment technologies in specific food products, including meat and poultry, seafood, fruits and vegetables. Summarises the latest research on sensor technologies for online and high-throughput screening of food Covers high-throughput screening and the current and forecast state of rapid contaminant detection technologies Looks at the use of optical and electrochemical biosensors and hyperspectral imaging in food safety assessment and the application of these technologies in specific food products
High Throughput Screening In Drug Discovery
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Author : Amancio Carnero
language : en
Publisher: CRC Press
Release Date : 2017-02-15
High Throughput Screening In Drug Discovery written by Amancio Carnero and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-15 with categories.
Drug discovery is a highly complex and multidisciplinary process. High throughput screening (HTS) uses the technologies of automation to collect a large amount of experimental data in a relatively short time. This book presents a comprehensive view of the HTS process for drug discovery, with its benefits and pitfalls, advantages, and problems. It provides an overview of different platforms and examples of successful applications of HTS in drug discovery using different technologies applied to each specific project.