Channel
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Ion Channels
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Author : James N. C. Kew
language : en
Publisher:
Release Date : 2010
Ion Channels written by James N. C. Kew and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
Photoshop Cs3 Channels And Masks Bible
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Author : Stephen Romaniello
language : en
Publisher: John Wiley & Sons
Release Date : 2007-05-07
Photoshop Cs3 Channels And Masks Bible written by Stephen Romaniello and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-07 with Computers categories.
"Photoshop channels and masks are complex and powerful tools that give designers tremendous control over color and make it easy to create composite images. This title aims to untangle the complexities of channels and masks, and shows Photoshop users how to use them like the pros do, offering real-world examples"--Publisher's description.
Transduction Channels In Sensory Cells
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Author : Stephan Frings
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Transduction Channels In Sensory Cells written by Stephan Frings and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
This is the first book to provide a molecular level explanation of how the senses work, linking molecular biology with sensory physiology to deduce the molecular mechanism of a key step in sensory signal generation. The editors have assembled expert authors from all fields of sensory physiology for an authoritative overview of the mechanisms of sensory signal transduction in both animals and plants. They systematically cover phototransduction, chemosensory transduction, mechanotransduction, temperature and pain perception, as well as specialized receptors for electrical and magnetic signals. Required reading for biologists, physiologists and medical researchers with an interest in sensory physiology.
Ion Channels In Health And Disease
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Author : Geoffrey S. Pitt
language : en
Publisher: Academic Press
Release Date : 2016-10-04
Ion Channels In Health And Disease written by Geoffrey S. Pitt and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-04 with Science categories.
Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues
Mechanisms Of Ion Channels Voltage Dependency
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Author : Gildas Loussouarn
language : en
Publisher: Frontiers E-books
Release Date :
Mechanisms Of Ion Channels Voltage Dependency written by Gildas Loussouarn and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Voltage-gated ion channels are transmembrane proteins in which at least one gate is controlled by the transmembrane potential. They are frequently very selectively permeable to sodium (Nav channels), potassium (Kv channels) or calcium (Cav channels) ions. Depending on the channels, opening of the activation gate is triggered by membrane depolarization (Kv, Nav and Cav channels) or hyperpolarization (HCN channels for instance). In addition, in many voltage-gated channels, a so-called inactivation gate is also present. Compared to the activation gate, the latter is oppositely coupled to the potential: In Kv, Nav and Cav channels, upon membrane depolarization, the inactivation gate closes whereas the activation gate opens. Depending on the cell types in which they are expressed and their physiological role, various voltage-dependent channels can be characterized by their conductance, ion selectivity, pharmacology and voltage-sensitivity. These properties are mainly dictated by the amino-acids sequence and structure of the pore forming subunit(s), presence of accessory subunit(s), membrane composition, intra- and extracellular ions concentration. Noteworthy, despite a profound variety of these ion channels characteristics, it seems that most of them obey to the same global, four-fold structure now obtained by several X-ray crystallography experiments. Given the wealth of electrophysiological, biochemical, optical, and structural data regarding ion channels voltage-dependency, we decided to put together in this e-book, up to date reviews describing the molecular details of these complex voltage-gated channels.
The Channel Advantage
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Author : Tim Furey
language : en
Publisher:
Release Date : 1999
The Channel Advantage written by Tim Furey and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
'The Channel Advantage' deals with one topic, and deals with it comprehensively and rigorously: how to construct a sales channel system that will yield world-class sales performance and durable competitive advantage. This book helps readers move decisivel.
The Dissent Channel
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Author : Elizabeth Shackelford
language : en
Publisher: Hachette UK
Release Date : 2020-05-12
The Dissent Channel written by Elizabeth Shackelford and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-12 with Political Science categories.
A young diplomat's account of her assignment in South Sudan, a firsthand example of US foreign policy that has failed in its diplomacy and accountability around the world. In 2017, Elizabeth Shackelford wrote a pointed resignation letter to her then boss, Secretary of State Rex Tillerson. She had watched as the State Department was gutted, and now she urged him to stem the bleeding by showing leadership and commitment to his diplomats and the country. If he couldn't do that, she said, "I humbly recommend that you follow me out the door." With that, she sat down to write her story and share an urgent message. In The Dissent Channel, former diplomat Elizabeth Shackelford shows that this is not a new problem. Her experience in 2013 during the precarious rise and devastating fall of the world's newest country, South Sudan, exposes a foreign policy driven more by inertia than principles, to suit short-term political needs over long-term strategies. Through her story, Shackelford makes policy and politics come alive. And in navigating both American bureaucracy and the fraught history and present of South Sudan, she conveys an urgent message about the devolving state of US foreign policy.
Fcc Record
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Author : United States. Federal Communications Commission
language : en
Publisher:
Release Date : 1991
Fcc Record written by United States. Federal Communications Commission and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Telecommunication categories.
The Channel Advantage
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Author : Tim Furey
language : en
Publisher: Routledge
Release Date : 2012-05-23
The Channel Advantage written by Tim Furey and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-23 with Business & Economics categories.
Channel innovation is separating market winners from market losers, and not just in leading-edge technology industries. In a business world where industry players are selling practically the same products at essentially the same prices at about the same cost, the only real source of sustainable competitive advantage is the sales channel: how you sell, not what you sell. Selling becomes a question of how to connect products with customers via the best mix of sales channels: the sales force, value-added partners, distributors, retail stores, telemarketing, and the Internet. In short, how companies sell has become as important as what they sell. 'The Channel Advantage' explains how leading companies develop strategies that integrate e-commerce, telemarketing, sales forces, and distributors to achieve superior sales performance and sustainable competitive advantage. Timothy R. Furey is chairman, CEO and co-founder of Oxford Associates, a privately held consulting firm specializing in sales and market strategy, e-commerce channel integration and market research, based in Bethesda, Maryland. Oxford has achieved an annual growth of more than forty percent since its creation in 1991 and was named one of America's 500 fastest growing private companies by Inc. Magazine in 1997. Furey, a pioneer in the use of hybrid sales and marketing strategies for blue chip companies, works extensively with senior management leadership teams to develop and implement go-to-market growth strategies. His clients include IBM, American Express, Marriott, Xerox, Fidelity Investments, Bristol-Myers Squibb, and Johnson & Johnson. Under his leadership, Oxford Associates has developed leading-edge strategies, business processes and systems for deploying and integrating multi-channel sales and marketing systems. They work to align products with the right customers via an appropriate mix of the Internet, telesales, distributors, value-added partners, and traditional sales force channels. Mr. Furey is the co-author of THE CHANNEL ADVANTAGE (Butterworth-Heinemann, August 31, 1999), which is endorsed by the CEOs of America Online, Lotus Development, Ocean Spray, and Xerox. Mr. Furey also serves on the Board of Directors of Alpha Industries (Nasdaq:AHAA), a leading semiconductor manufacturer for wireless telephone applications. Previously, Mr. Furey worked with Boston Consulting Group, Strategic Planning Associates, Kaiser Associates and the Marketing Science Institute. He earned a BA in Economics, cum laude, from Harvard University and an MBA from the Harvard Business School. Lawrence G. Friedman is an internationally recognized channel strategy consultant whose clients have included companies such as Lotus, AT&T, Canon, Compaq Digital Equipment, Microsoft and Bell Atlantic. He also held executive level positions at Andersen Consulting and Huthwaite, Inc., the sales research firm that developed the SPIN Selling Model. In 1996, Friedman, with Neil Rackham and Richard Ruff, co-authored the best-seller, GETTING PARTNERING RIGHT (McGraw-Hill). He is on the review board of the Journal of Selling and Major Account Management, which published his article, Multiple Channel Sales Strategy, in the April, 1999 issue. His firm, The Sales Strategy Institute, works with clients to identify and evaluate new go-to-market opportunities and conducts in-depth channel strategy workshops and seminars. Mr. Friedman is a frequent guest speaker and lecturer on sales and channel strategy throughout the United States, Europe and Asia. Mr. Friedman earned an MA from the University of Chicago.
Youtube How To Build And Optimize Your First Youtube Channel Marketing Seo Tips And Strategies For Youtube Channel Success
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Author : Tommy Swindali
language : en
Publisher: Tommy Swindali
Release Date : 2020-08-28
Youtube How To Build And Optimize Your First Youtube Channel Marketing Seo Tips And Strategies For Youtube Channel Success written by Tommy Swindali and has been published by Tommy Swindali this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-28 with Technology & Engineering categories.
Join The Global Phenomenon Now YouTube is the second largest search engine and the third most popular website we use on the Internet today. Creating a channel in YouTube is essential to becoming a part of this global phenomenon. Hosting videos on a website is good-intended. On the other hand, taking advantage of YouTube's marketing potential is way better. For brand managers, individuals, and small to big businesses, using YouTube to market videos and website content is a cost-effective way of growing customers and audiences. Optimized videos and a well-structured channel can effectively showcase a business or individual's brand. YouTube is not just a website where videos can be shared. Its use can be maximized by using it as a marketing tool for brand awareness and to drive YouTube viewers back to the channel owner's original website in order to convert them to sales leads. Building a successful YouTube channel is not a one-day or quick process. It can take time; lots of it. Read on for a step-by-step guide to creating a YouTube account, starting a channel and joining the global phenomenon! Here Is A Preview Of What You'll Learn... Creating a YouTube Channel Customizing a YouTube Channel Optimizing a YouTube Channel Building an Audience Creating Videos Built for a Target Audience User Engagement Audience Retention Sales Conversion And, Much, much more! Download your copy today!